本文關(guān)鍵詞： ROS 炎癥 神經(jīng)系統(tǒng)疾病　出處：《中國(guó)組織化學(xué)與細(xì)胞化學(xué)雜志》2016年03期 　論文類型：期刊論文

【摘要】：活性氧簇(reactive oxygen species,ROS)是生物有氧代謝過(guò)程中的一種副產(chǎn)品,它具有很強(qiáng)的化學(xué)反應(yīng)活性,在細(xì)胞信號(hào)傳導(dǎo)和保持機(jī)體穩(wěn)定性方面起著重要作用。在某些因素刺激下,ROS會(huì)急劇增多,進(jìn)而通過(guò)細(xì)胞氧化應(yīng)激影響一系列信號(hào)轉(zhuǎn)導(dǎo)途徑引起炎癥反應(yīng)。ROS的異常表達(dá)常與神經(jīng)系統(tǒng)疾病發(fā)生密切相關(guān),它介導(dǎo)炎癥反應(yīng)的發(fā)生,參與神經(jīng)系統(tǒng)疾病的發(fā)展和惡化。
[Abstract]:Reactive oxygen speciesros (Ros) is a by-product of biological aerobic metabolism, which has a strong chemical reaction activity. It plays an important role in cell signal transduction and maintaining the stability of the body. Ros will increase rapidly under the stimulation of some factors. Furthermore, the abnormal expression of Ros through a series of signal transduction pathways induced by oxidative stress is closely related to the occurrence of nervous system diseases, which mediates the occurrence of inflammatory response. Participate in the development and deterioration of nervous system diseases.
【作者單位】： 華中科技大學(xué)同濟(jì)醫(yī)學(xué)院神經(jīng)生物學(xué)系;
【基金】：國(guó)家自然科學(xué)基金資助項(xiàng)目(81471490)
【分類號(hào)】：R741
【正文快照】： 神經(jīng)元丟失是多種類型神經(jīng)系統(tǒng)疾病包括阿爾茨海默病(Alzheimer’s disease,AD)、帕金森病(Par-kinson’s disease,PD)、多發(fā)性硬化癥(multiple sclero-sis,MS)、腦缺血(cerebral ischemia,CI)、抑郁癥(depressive disorders)等發(fā)生發(fā)展的關(guān)鍵環(huán)節(jié)。氧化應(yīng)激、線粒體功能障礙，

本文編號(hào)：1483224