本文關(guān)鍵詞： 腦微出血 同型半胱氨酸 腦小血管病變 磁敏感加權(quán)成像　出處：《青島大學(xué)》2017年碩士論文　論文類型：學(xué)位論文

【摘要】：目的:研究急性動脈粥樣硬化性腦梗死患者血清同型半胱氨酸與腦微出血的相關(guān)性。方法:連續(xù)收集2015年4月至2016年4月在本院神經(jīng)內(nèi)科入院治療的急性動脈粥樣硬化性腦梗死患者129例。根據(jù)磁敏感加權(quán)成像技術(shù)對患者進行分析,將患者按有、無微出血分為兩組。記錄并比較患者一般臨床資料、實驗室檢驗結(jié)果、影像學(xué)資料特點是否存在差異,采用方差分析、卡方檢驗、秩和檢驗比較微出血的危險因素,并運用logistic回歸分析腦微出血的獨立危險因素。結(jié)果:納入研究的129例腦梗死患者中,共檢出微出血39例,占48.8%,CMBs數(shù)目1-13個,平均3.31個。其中12名患者CMBs數(shù)目1個,18名患者CMBs數(shù)目,在2-5個,6名患者CMBs數(shù)目≥6個。其次腦葉CMBs占20.5%,深部微出血占51.3%,余下的為混合微出血。根據(jù)患者有無CMBS分為兩組,兩組間高血壓(P=0.034)、糖尿病(P=0.002)、陳舊性腔梗(P0.001)、腦白質(zhì)病(P0.001)、血清同型半胱氨酸水平(P0.001),差異有統(tǒng)計學(xué)意義;logistic回歸分析顯示,陳舊性腔梗(OR值=7.667,P0.001),血清同型半胱氨酸水平(OR值=1.317,P0.001),兩組之間比較差異有統(tǒng)計學(xué)意義。結(jié)論:在神經(jīng)內(nèi)科住院的急性動脈粥樣硬化性腦梗死患者中,微出血相當(dāng)常見。磁敏感序列對于微出血的檢出有著重要作用。高血壓、糖尿病、陳舊性腔梗、腦白質(zhì)病變、血清同型半胱氨酸水平是急性腦梗死患者發(fā)生微出血的相關(guān)因素。陳舊性腔梗和血清同型半胱氨酸水平是急性動脈粥樣硬化性腦梗死患者微出血的獨立危險因素。
[Abstract]:Objective: To study the correlation of microbleeds in serum of patients with acute atherosclerotic cerebral infarction homocysteine and brain. Methods: a total of 129 consecutive cases from April 2015 to April 2016 in the hospital neurology department of our hospital for treatment of patients with acute atherosclerotic cerebral infarction. According to the analysis of magnetic susceptibility weighted imaging for patients, the patients in a micro hemorrhage divided into two. Group. Recorded and compared in patients with clinical data, laboratory tests, imaging characteristics and whether there are differences, using variance analysis, chi square test, rank sum test to compare the micro bleeding risk factors, and using the logistic regression analysis of independent risk factors for cerebral microbleeds. Results: 129 cases of cerebral infarction were included in the study. And there were micro hemorrhage in 39 cases, accounting for 48.8%, the number of CMBs 1-13, an average of 3.31. 12 of the patients CMBs number 1, 18 patients in a number of CMBs, 2-5, 6 The number of patients with CMBs = 6. Second lobe CMBs accounted for 20.5%, deep micro hemorrhage accounted for 51.3%, the rest of the mixed micro hemorrhage. According to the patients with CMBS were divided into two groups, two groups of hypertension (P=0.034), diabetes mellitus (P=0.002), old lacunar infarction (P0.001), cerebral white matter disease (P0.001), the level of serum homocysteine (P0.001), the difference was statistically significant; logistic regression analysis showed that old lacunar infarction (OR = =7.667, P0.001), the level of serum homocysteine (OR = =1.317, P0.001), the difference between the two groups was statistically significant. Conclusions: in patients with acute atherosclerotic neurology the hospital of cerebral microbleeds, quite common. The magnetic sensitive sequence for microbleed detection plays an important role. Hypertension, diabetes mellitus, old lacunar infarction and cerebral white matter lesions, serum homocysteine level is related to factors of micro hemorrhage in patients with acute cerebral infarction. Chen The level of the old cavities and serum homocysteine is an independent risk factor for micro bleeding in patients with acute atherosclerotic cerebral infarction.

【學(xué)位授予單位】：青島大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R743.3

【參考文獻】

相關(guān)期刊論文 前4條

1 韋世文;韋玉魯;覃維含;譚毅;;高同型半胱氨酸血癥與缺血性腦血管疾病相關(guān)性的研究進展[J];中國臨床新醫(yī)學(xué);2016年12期

2 張祥;李翔;朱冬青;喬鍵;陳向軍;;高同型半胱氨酸血癥與視神經(jīng)脊髓炎關(guān)系的探討[J];中國臨床神經(jīng)科學(xué);2014年03期

3 劉力生;;中國高血壓防治指南2010[J];中華高血壓雜志;2011年08期

4 ;中國急性缺血性腦卒中診治指南2010[J];中華神經(jīng)科雜志;2010年02期

，

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