發(fā)布時(shí)間：2018-01-10 04:27

  本文關(guān)鍵詞：低頻重復(fù)經(jīng)顱磁刺激治療腦卒中后失語(yǔ)的Meta-分析　出處：《新疆醫(yī)科大學(xué)》2015年碩士論文　論文類型：學(xué)位論文

  更多相關(guān)文章： 重復(fù)經(jīng)顱磁刺激 腦卒中 失語(yǔ) 系統(tǒng)評(píng)價(jià)

【摘要】：目的：應(yīng)用系統(tǒng)評(píng)價(jià)的方法探討低頻重復(fù)經(jīng)顱磁刺激(repetitive transcranial magnetic stimulation, rTMS)對(duì)腦卒中后失語(yǔ)的療效與安全性,為失語(yǔ)癥的輔助治療方法提供證據(jù)。方法：計(jì)算機(jī)檢索相關(guān)期刊論文(CNKI)、維普數(shù)據(jù)庫(kù)(VIP)萬(wàn)方數(shù)據(jù)庫(kù)、中國(guó)生物醫(yī)學(xué)文獻(xiàn)數(shù)據(jù)庫(kù)(CBM)、PubMed、Science Direct、Web of Science,根據(jù)制定的納入標(biāo)準(zhǔn)、排除標(biāo)準(zhǔn)收集低頻rTMS治療腦梗死后失語(yǔ)的隨機(jī)對(duì)照試驗(yàn)(randomized control trials RCTs),采用Reviw Manager 5.3進(jìn)行分析。結(jié)果：共納入4篇RCTs,包括137例患者。Meta分析結(jié)果顯示,失語(yǔ)總評(píng)分[SMD=0.71, 95%CI(0.28,1.13)]存在輕度異質(zhì)性(I2=13%),但治療后差異有統(tǒng)計(jì)學(xué)意義。復(fù)述亞測(cè)驗(yàn)組評(píng)分[SMD=0.54,95%CI (0.19,0.89)]、命名亞測(cè)驗(yàn)組[SMD=0.50,95%CI (0.05,0.95)]均無(wú)異質(zhì)性(I2=0%),治療后較治療前有明顯提高,差異有統(tǒng)計(jì)學(xué)意義。理解亞測(cè)驗(yàn)組評(píng)分[SMD=0.28,95%CI(-0.44,1.01)]有中度異質(zhì)性(I2=54%),治療前后差異無(wú)統(tǒng)計(jì)學(xué)意義。4項(xiàng)研究的所有受試者均無(wú)不良反應(yīng)。結(jié)論：低頻rTMS對(duì)腦卒中后失語(yǔ)患者語(yǔ)言功能的恢復(fù)具有明顯效果,且無(wú)不良反應(yīng)。
[Abstract]:Objective: To explore the evaluation method of the application system of low frequency repetitive transcranial magnetic stimulation (repetitive transcranial magnetic stimulation, rTMS) on the efficacy and safety of aphasia after stroke, to provide evidence for treatment of aphasia. Methods: computer retrieval China Journal Full-text Database (CNKI), VIP database Wanfang database (VIP), China the biomedical literature database (CBM), PubMed, Science Direct, Web of Science, according to the inclusion criteria, exclusion criteria to collect randomized controlled trials of low frequency rTMS in the treatment of cerebral infarction after aphasia (randomized control trials RCTs), using Reviw Manager 5.3 were analyzed. Results: 4 RCTs were included, including 137 cases of patients with the results of.Meta analysis show that the total score of [SMD=0.71 aphasia, 95%CI (0.28,1.13)] mild heterogeneity (I2=13%), but after treatment, the difference was statistically significant. Repeat the test sub group The score of [SMD=0.54,95%CI (0.19,0.89)], named sub test group [SMD=0.50,95%CI (0.05,0.95)] no heterogeneity (I2=0%) after treatment, significantly higher than before, the difference was statistically significant. Comprehension subtests score of group [SMD=0.28,95%CI (-0.44,1.01)] with moderate heterogeneity (I2=54%), all the subjects were statistically significant.4 study on the difference before and after treatment were no adverse reactions. Conclusion: low frequency rTMS on the recovery of language function in patients with aphasia after stroke has obvious effect, and no adverse reaction.

【學(xué)位授予單位】：新疆醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2015
【分類號(hào)】：R743.3;R49
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本文編號(hào)：1403876