本文關(guān)鍵詞：進展性缺血性腦卒中與血脂水平的分層研究　出處：《吉林大學(xué)》2015年碩士論文　論文類型：學(xué)位論文

  更多相關(guān)文章： 進展性卒中 危險因素 血脂水平

【摘要】：背景及目的：進展性缺血性卒中（progressive ischemic stroke，PIS）簡稱進展性卒中（stroke in progression，SIP）是指發(fā)病6h后，無論是否接受治療病情仍逐漸進展惡化甚至死亡的急性腦梗死。進展性卒中嚴(yán)重影響卒中患者的預(yù)后，由于缺乏有效地治療措施，其致殘率、死亡率都明顯高于非進展性腦梗死。因此，提高對SIP的認(rèn)識，盡早對其危險因素進行干預(yù)，，對改善腦血管病的預(yù)后，降低致殘率和死亡率，有重要意義。本研究通過SIP組和非SIP組的對比，探索血脂水平變化與SIP發(fā)生發(fā)展的關(guān)系。 方法：對入組的194例患者一般臨床資料、血清總膽固醇、甘油三酯、高密度脂蛋白膽固醇、低密度脂蛋白膽固醇、脂蛋白檢測結(jié)果，采用Epidata3.1建立數(shù)據(jù)庫，SPSS17.0統(tǒng)計軟件進行資料的統(tǒng)計分析。符合正態(tài)分布的計量資料采用X±S表示其集中趨勢和離散趨勢，組間比較采用t檢驗；不符合正態(tài)分布的計量資料采用M±Q表示其集中趨勢和離散趨勢，組間比較用秩和檢驗；計數(shù)資料用率或構(gòu)成比表示，組間比較采用χ2檢驗。 結(jié)果：1.（1）血清3.84mmol/L≤TC＜4.66mmol/L者SIP發(fā)生率（71.0%）高于TC＜3.84mmol/L者（33.3%），血清3.84mmol/L≤TC＜4.66mmol/L者SIP發(fā)生率（71.0%）高于TC≥4.66mmol/L者（53.7%）。（2）血清TC＜3.84mmol/L者SIP發(fā)生率（33.3%）低于非SIP（66.7%），3.84mmol/L≤TC＜4.66mmol/L者SIP發(fā)生率（71.0%）高于非SIP（29.0%）。2.血清0.85mmol/L≤TG＜1.16mmol/L者SIP發(fā)生率(71.1%)高于TG＜0.85mmol/L者（33.3%）。3.血清LDL-C≥4.39mmol/L者SIP發(fā)生率(83.3%)高于2.90mmol/L≤LDL-C＜4.39mmol/L者（50.5%），血清LDL-C≥4.39mmol/L者SIP發(fā)生率（83.3%）高于LDL-C＜2.90mmol/L者（58.2%）。4.血清HDL-C＜1.16mmol/L者SIP發(fā)生率（60.4%）高于1.16mmol/L≤HDL-C＜1.28mmol/L者(36.4%)。5.（1）血清0.13mmol/L≤Lpa＜0.37mmol/L者SIP發(fā)生率(68.9%)高于Lpa＜0.13mmol/L者（39.3%）。（2）血清Lpa＜0.13mmol/L者SIP發(fā)生率（39.3%）低于非SIP（60.7%），0.13mmol/L≤Lpa＜0.37mmol/L者SIP發(fā)生率（68.9%）高于非SIP（31.1%）。 結(jié)論：1、血清TC和Lpa在低水平時SIP發(fā)病率低于非SIP，在中水平時SIP發(fā)病率高于非SIP，故將血清TC控制在3.84mmol/L以下，血清Lpa控制在0.13mmol/L以下，有利于預(yù)防卒中進展。2、血清TG、LDL-C和HDL-C處在任一水平，SIP與非SIP發(fā)病率無明顯差別。3、血清TC在中水平時，SIP發(fā)生率最高；血清LDL-C在高水平時，SIP發(fā)生率最高；血清TG和Lpa在中水平時，SIP發(fā)生率高于在低水平時；血清HDL-C在低水平時，SIP發(fā)生率高于在中水平時。4、初步建立了進展性卒中血脂水平評估量表，在臨床應(yīng)用中，可根據(jù)此表預(yù)測進展性卒中發(fā)生風(fēng)險。
[Abstract]:Background & AIM: progressive ischemic stroke in progressive ischemic stroke. PIS) refers to 6 hours after onset of stroke in progression. Progressive stroke seriously affects the prognosis of stroke patients, and the disability rate is due to the lack of effective treatment. The mortality rate was significantly higher than that of non-progressive cerebral infarction. Therefore, to improve the prognosis of cerebrovascular disease and reduce disability rate and mortality, we should improve the understanding of SIP and intervene its risk factors as early as possible. Through the comparison between SIP group and non-SIP group, the relationship between the changes of blood lipid level and the occurrence and development of SIP was explored. Methods: the general clinical data of 194 patients were analyzed. Serum total cholesterol, triglyceride, high density lipoprotein cholesterol, low density lipoprotein cholesterol and lipoprotein were detected. The statistical software SPSS 17.0 was used to establish the database with Epidata3.1. The measurement data in accordance with the normal distribution were expressed by X 鹵S as the concentrated trend and the discrete trend. T test was used for comparison between groups. M 鹵Q was used to indicate the trend of concentration and dispersion, and the rank sum test was used for the comparison between groups. The counting data were expressed by rate or composition ratio, and 蠂 2 test was used for comparison between groups. Results the incidence of SIP in 3.84 mmol / L 鈮

本文編號：1373212