發(fā)布時(shí)間：2017-12-28 07:18

  本文關(guān)鍵詞：依達(dá)拉奉注射液聯(lián)合丁苯酞治療急性腦梗死的療效觀察　出處：《藥物評(píng)價(jià)研究》2016年04期 　論文類型：期刊論文

  更多相關(guān)文章： 急性腦梗死 依達(dá)拉奉 丁苯酞

【摘要】：目的觀察依達(dá)拉奉聯(lián)合丁苯酞治療急性腦梗死的臨床療效。方法選取200例在寶雞市人民醫(yī)院就診的急性腦梗死患者,隨機(jī)分為觀察組100例,給予依達(dá)拉奉注射液聯(lián)合丁苯酞治療,對(duì)照組100例,僅給予丁苯酞治療。對(duì)兩組患者的臨床療效、NDS評(píng)分、Mo CA評(píng)分、ADL評(píng)分及血清C-反應(yīng)蛋白(hs-CRP)水平及不良反應(yīng)進(jìn)行比較。結(jié)果觀察組總有效率(92%)顯著高于對(duì)照組(79%),差異具有統(tǒng)計(jì)學(xué)意義(P0.05)。治療后兩組患者神經(jīng)功能缺損均有所下降,認(rèn)知功能均有所改善,但觀察組神經(jīng)功能缺損下降顯著低于對(duì)照組,認(rèn)知功能改善優(yōu)于對(duì)照組,觀察組ADL評(píng)分顯著高于對(duì)照組,hs-CRP水平顯著低于對(duì)照組,差異具有統(tǒng)計(jì)學(xué)意義(P0.05)。所有患者治療過(guò)程中無(wú)明顯不良反應(yīng)。結(jié)論依達(dá)拉奉注射液聯(lián)合丁苯酞對(duì)急性腦梗死療效顯著,安全性好,值得臨床推廣。
[Abstract]:Objective To observe the clinical efficacy of edaravone combined with butylphthalide in the treatment of acute cerebral infarction. Methods 200 patients with acute cerebral infarction who were treated in Shaanxi Baoji People's Hospital were randomly divided into observation group and control group, 100 cases were given Edaravone Injection combined with butylphthalide, while 100 cases in control group were treated with butylphthalide. The clinical efficacy, NDS score, Mo CA score, ADL score and serum C- reactive protein (hs-CRP) level and adverse reaction were compared in two groups of patients. Results the total effective rate of the observation group (92%) was significantly higher than that of the control group (79%), and the difference was statistically significant (P0.05). After treatment, two groups of patients with neurological deficits were decreased, the cognitive function were improved, but the observation group decreased neurological deficit was significantly lower than the control group, the cognitive function was better than the control group, ADL score in observation group was significantly higher than the control group, the level of hs-CRP was significantly lower than the control group, the difference was statistically significant (P0.05). There was no obvious adverse reaction during the treatment of all patients. Conclusion the combination of Edaravone Injection and butylphthalide has a significant effect on acute cerebral infarction, and it is safe and worthy of clinical application.
【作者單位】： 寶雞市人民醫(yī)院干部病區(qū);華陰市人民醫(yī)院神經(jīng)內(nèi)科;
【分類號(hào)】：R743.3
【正文快照】： 急性腦梗死是神經(jīng)內(nèi)科的常見(jiàn)病,常伴有不同程度的認(rèn)知功能障礙,有很高的發(fā)病率和致殘率�；颊邏乃绤^(qū)的神經(jīng)細(xì)胞迅速死亡,而局部微循環(huán)障礙和自由基損傷是引起神經(jīng)細(xì)胞凋亡的主要原因[1-2]。丁苯酞通過(guò)抗腦缺血和改善缺血區(qū)微循環(huán)等恢復(fù)神經(jīng)功能和改善認(rèn)知功能[3]。依達(dá)拉奉是

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