本文選題：乙肝病毒 + 乙肝疫苗��； 參考：《南京醫(yī)科大學(xué)學(xué)報(bào)(自然科學(xué)版)》2014年12期

【摘要】：目的 :評(píng)價(jià)近期淮安市淮安區(qū)新生兒乙肝疫苗計(jì)劃免疫策略實(shí)施效果及其影響因素。方法 :采用血清流行病學(xué)調(diào)查方法,調(diào)查7~12月齡幼兒的乙肝疫苗接種史,檢測(cè)HBs Ag、抗-HBs和抗-HBs。對(duì)新生兒的乙肝疫苗免疫效果及其影響因素進(jìn)行分析評(píng)價(jià)。結(jié)果:共對(duì)2 320名幼兒開(kāi)展了調(diào)查。乙肝疫苗計(jì)劃免疫及時(shí)接種率高達(dá)99.6%,均全程接種了疫苗。監(jiān)測(cè)對(duì)象的HBs Ag陽(yáng)性率0.13%,核心抗體陽(yáng)性率為2.1%,估計(jì)乙肝疫苗保護(hù)率在93.4%,母嬰阻斷成功率為91.6%,幼兒HBs Ag陽(yáng)性的原因?yàn)槟笅胱钄嗍?所有母嬰阻斷失敗幼兒的母親為HBe Ag陽(yáng)性感染者。接種5 g苗的幼兒抗體低、無(wú)應(yīng)答率為26.3%,高于計(jì)劃免疫中接種10 g疫苗的地區(qū)。出生低體重幼兒的低、無(wú)應(yīng)答率高于出生正常體重幼兒。結(jié)論 :目前乙肝疫苗計(jì)劃免疫的規(guī)范接種率高,幼兒HBV慢性感染率低,幼兒的慢性HBV感染主要?dú)w因于母嬰阻斷失敗。應(yīng)提高乙肝疫苗計(jì)免免疫中的接種劑量。
[Abstract]:Objective: to evaluate the effect and influencing factors of immunization strategy of hepatitis B vaccine for newborns in Huaian district of Huaian city. Methods: a seroepidemiological survey was conducted to investigate the history of hepatitis B vaccination in children aged 7 to 12 months, and to detect anti-HBs, anti-HBs and anti-HBs. The immune effect of hepatitis B vaccine in neonates and its influencing factors were analyzed and evaluated. Results: a total of 2 320 children were investigated. Hepatitis B vaccine program immunization coverage rate as high as 99.6 percent, the whole process was vaccinated. The positive rate of HBs Ag was 0.13 and the positive rate of core antibody was 2.1. It was estimated that the protective rate of hepatitis B vaccine was 93.40.The success rate of mother and child blocking was 91.6. The reason of HBs Ag positive in young children was the failure of mother and child block. All the mothers who failed to block the mother and child were HBe Ag positive. The antibody of children inoculated with 5 g vaccine was low and the non-response rate was 26.3%, which was higher than that of the area inoculated with 10 g vaccine in the planned immunization. The low-weight and non-response rate of low-weight infants was higher than that of normal-weight children. Conclusion: the standard immunization rate of hepatitis B vaccine is high, the chronic infection rate of HBV is low, and the failure of mother and child block is the main cause of chronic HBV infection. The dose of hepatitis B vaccine in immunization should be increased.
【作者單位】： 淮安市淮安區(qū)疾病預(yù)防控制中心;江蘇省疾病預(yù)防控制中心;
【基金】：國(guó)家科技重大專(zhuān)項(xiàng)(2008ZX10002-001)
【分類(lèi)號(hào)】：R186

【參考文獻(xiàn)】

相關(guān)期刊論文 前3條

1 王毓;翟祥軍;許衛(wèi)國(guó);鮑倡俊;朱葉飛;殷曉梅;彭紅;朱立國(guó);張婷婷;陳新峰;杜國(guó)明;柳麗江;王躍進(jìn);宗俊;蔣衛(wèi)平;姚根紅;曹民權(quán);吳淑華;汪華;;江蘇省一般人群乙型肝炎表面抗原陽(yáng)性率與乙肝疫苗免疫的關(guān)系[J];南京醫(yī)科大學(xué)學(xué)報(bào)(自然科學(xué)版);2011年04期

2 莊輝;乙型肝炎疫苗免疫[J];中華肝臟病雜志;2003年04期

3 梁曉峰,陳園生,王曉軍,賀雄,陳麗娟,王駿,林長(zhǎng)纓,白呼群,嚴(yán)俊,崔鋼,于競(jìng)進(jìn);中國(guó)3歲以上人群乙型肝炎血清流行病學(xué)研究[J];中華流行病學(xué)雜志;2005年09期

【共引文獻(xiàn)】

相關(guān)期刊論文 前10條

1 胡九東;劉洋;李瑩;張瑋;邢練軍;;中西醫(yī)結(jié)合抗病毒治療慢乙肝研究進(jìn)展[J];中醫(yī)藥臨床雜志;2011年03期

2 韓紅梅;;乙肝疫苗免疫預(yù)防進(jìn)展[J];安徽預(yù)防醫(yī)學(xué)雜志;2010年05期

3 姚傳磊;代鐸;陳玉虹;趙娟;張飛;;淮南市部分人群乙肝預(yù)防相關(guān)知識(shí)態(tài)度調(diào)查[J];安徽預(yù)防醫(yī)學(xué)雜志;2011年02期

4 王永英;;我院2005年9月～2007年9月防治慢性乙型肝炎藥應(yīng)用分析[J];安徽醫(yī)藥;2010年07期

5 葉s，

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