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  本文關鍵詞：新疆維、漢族人群MTHFR C677T多態(tài)性遺傳流行病學調查　出處：《新疆醫(yī)科大學》2011年碩士論文　論文類型：學位論文

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【摘要】：目的：研究新疆維、漢族人群5,10-亞甲基四氫葉酸還原酶基因(MTHFR)C677T多態(tài)性的分布特點,并預知維、漢族人群對服用甲氨蝶呤后不良反應的差異性。方法：應用限制性片段長度多態(tài)性擴增技術(PCR-RFLP)分析MTHFR C677T基因型在新疆134例維族和166例漢族人群的分布頻率。結果：新疆漢族人群MTHFR C677T基因型頻率分別為C/C21.7%、C/T53.0%和T/T25.3%,維族為C/C16.4%、C/T80.6%和T/T2.96%,二者差異有統(tǒng)計學意義(P0.05)。維族男性該基因型頻率分別為16.95%、79.7%和3.39%,女性為9.1%、88.0%和2.67%(P0.05)；漢族男性為25.8%、47.1%和27.1,女性為17.28%、59.26%和23.46%,二者差異無統(tǒng)計學意義(P0.05)。結論：新疆維、漢族MTHFR C677T的三種基因型CC、CT、TT的分布存在差異,三種基因型的分布在性別間未見差異,并預知在臨床中如果服用相同劑量甲氨蝶呤時,漢族患者出現(xiàn)不良反應的幾率和程度比維族患者要高。同時,服用相同劑量甲氨蝶呤后MTHFR 677TT基因型的患者發(fā)生副作用的幾率和程度比MTHFR677CC/CT要高。
[Abstract]:Objective: to study the distribution of C677T polymorphism of 5-methylenetetrahydrofolate reductase gene (MTHFRN) in Weiwei, Xinjiang, and to predict the characteristics of the polymorphism. Differences of adverse reactions after methotrexate in Han population methods: PCR-RFLP was used to amplify restriction fragment length polymorphism (RFLP). To analyze the distribution frequency of MTHFR C677T genotypes in 134 Uygur and 166 Han population in Xinjiang. Results: MTHFR in Xinjiang Han population. The frequency of C677T genotypes was C / C 21.7%. C / T 53.0% and T / T 25. 3%, Uygur = C / C 16.4% and T / T 80.6% and T / T 2.96%. The frequency of this genotype in Uygur males was 16.95% and 3.39%, respectively, and that in females was 9.1%. 88.0% and 2.67; 47.1% and 27.1% of Han males and 17.2828% and 23.46% females respectively. Conclusion: the distribution of the three genotypes of MTHFR C677T in Xinjiang and Han nationality is different. The distribution of the three genotypes was not different between sexes, and predicted that if the same dose of methotrexate was taken in clinic, the probability and degree of adverse reactions in Han patients was higher than that in Uygur patients. At the same time. Patients taking the same dose of methotrexate were more likely and more likely to develop side effects than those with MTHFR677CC/CT.
【學位授予單位】：新疆醫(yī)科大學
【學位級別】：碩士
【學位授予年份】：2011
【分類號】：R181.3;R394

【引證文獻】

相關碩士學位論文 前1條

1 王朋;維吾爾族、漢族MTHFR基因A1298C多態(tài)性與A1298C、C677T基因多態(tài)性與甲氨蝶呤副作用的相關研究[D];新疆醫(yī)科大學;2012年

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本文編號：1435798