【摘要】：目的:研究骨皮質(zhì)切開(kāi)術(shù)對(duì)大鼠正畸牙移動(dòng)的影響及其組織學(xué)改建機(jī)制。方法:選用健康未孕雌性SD大鼠48只,隨機(jī)分為骨皮質(zhì)切開(kāi)手術(shù)組和對(duì)照組。在手術(shù)組大鼠行骨皮質(zhì)切開(kāi)術(shù),對(duì)照組大鼠行對(duì)照手術(shù)后,構(gòu)建正畸牙移動(dòng)模型。在牙移動(dòng)0、1、3、7d分別處死2組大鼠各6只。測(cè)量牙移動(dòng)距離并制備組織學(xué)切片行HE染色、骨鈣素及Runx2免疫組織化染色。采用SPSS16.0軟件包對(duì)數(shù)據(jù)進(jìn)行統(tǒng)計(jì)分析,P0.05為差異有顯著性。結(jié)果:骨皮質(zhì)切開(kāi)組大鼠在移動(dòng)3d后牙移動(dòng)速度大于假手術(shù)組大鼠(P0.05)。牙移動(dòng)第3天和第7天,手術(shù)組大鼠張力區(qū)新骨面積大于假手術(shù)大鼠(P0.05),同時(shí),此時(shí)手術(shù)組張力區(qū)骨鈣素陽(yáng)性成骨細(xì)胞增加(P0.05)。手術(shù)組大鼠牙移動(dòng)3d及7d時(shí)張力區(qū)Run2表達(dá)均高于假手術(shù)組(P0.05)。結(jié)論:骨皮質(zhì)切開(kāi)術(shù)加速正畸牙移動(dòng)的同時(shí)促進(jìn)牙周組織成骨活性,這可能是保障牙移動(dòng)安全性的關(guān)鍵因素。
[Abstract]:Objective: to study the effect of cortical osteotomy on orthodontic tooth movement in rats and its histological remodeling mechanism. Methods: 48 healthy non-pregnant female SD rats were randomly divided into cortical incision group and control group. The model of orthodontic tooth movement was established after cortical osteotomy in operation group and control group. The rats of the two groups were killed on 7 days after tooth movement. The distance of tooth movement was measured and histological sections were prepared for HE staining, osteocalcin and Runx2 immunohistochemical staining. SPSS16.0 software package was used for statistical analysis of the data, P0.05 for the difference was significant. Results: the speed of tooth movement in the osteocortical incision group was higher than that in the sham operation group after 3 days (P0.05). On the 3rd and 7th day of tooth movement, the area of new bone in tension zone in operation group was larger than that in sham operation group (P0.05). At the same time, osteocalcin positive osteoblasts in tension area of operation group increased (P0.05). The expression of Run2 in tension zone was significantly higher in the operation group than in the sham operation group at 3 and 7 days after tooth movement (P0.05). Conclusion: osteotomy can accelerate orthodontic tooth movement and promote osteogenic activity of periodontal tissue, which may be the key factor to ensure the safety of tooth movement.
【作者單位】： 徐州醫(yī)科大學(xué)附屬徐州口腔醫(yī)院種植中心;徐州醫(yī)科大學(xué)口腔醫(yī)學(xué)院;徐州醫(yī)科大學(xué)附屬徐州口腔醫(yī)院;
【分類(lèi)號(hào)】：R783.5

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