【摘要】：目的:本實(shí)驗(yàn)采用動(dòng)物實(shí)驗(yàn),通過在實(shí)驗(yàn)性根尖周病動(dòng)物模型上完成顯微根尖手術(shù),以iRoot BP、MTA和氧化鋅作為根尖倒充填材料,術(shù)后6個(gè)月對(duì)比X線片和病理組織切片指標(biāo),評(píng)估三者的療效。方法:誘導(dǎo)4只beagle犬的下頜第二、第三、第四前磨牙形成實(shí)驗(yàn)性根尖周炎后常規(guī)行根管治療,術(shù)后1周行顯微根尖外科手術(shù)。48個(gè)根管隨機(jī)的分為3組,每組16個(gè)根管,分組如下:對(duì)照組:氧化鋅為倒充填材料實(shí)驗(yàn)組1:MTA為倒充填材料實(shí)驗(yàn)組2:iRoot BP為倒充填材料術(shù)后6個(gè)月,拍攝根尖X線片后處死實(shí)驗(yàn)動(dòng)物獲得根尖周組織標(biāo)本,HE染色制作組織病理學(xué)切片,評(píng)價(jià)氧化鋅、iRoot BP和MTA的療效。結(jié)果:1、術(shù)后6個(gè)月的成功率,X線片結(jié)果顯示,對(duì)照組氧化鋅為81.2%、iRoot BP組為93.8%、MTA組為93.8%,3種材料間差異無統(tǒng)計(jì)學(xué)意義;2、組織病理切片結(jié)果顯示:MTA組和iRoot BP組與氧化鋅組相比,炎癥程度輕,差異有統(tǒng)計(jì)學(xué)意義(X~2=17.328,p=0.008,p0.05),iRoot BP組的炎癥細(xì)胞數(shù)目和MTA組之間差異無統(tǒng)計(jì)學(xué)意義(X~2=0.899,p=0.826,p0.05);MTA組和iRoot BP組的骨質(zhì)沉積率高于氧化鋅組,MTA是3種材料中唯一有硬組織直接沉積的倒充填材料。結(jié)論:1、X線片結(jié)果顯示,作為倒充填材料,氧化鋅、MTA和iRoot BP的療效差異無統(tǒng)計(jì)學(xué)意義;2、組織病理學(xué)結(jié)果顯示,3種材料均可促進(jìn)根尖周硬組織的再生,iRoot BP與MTA對(duì)根尖周組織的炎癥刺激較輕,MTA有最佳的生物相容性。
[Abstract]:Objective: this experiment was carried out on the animal model of experimental periapical disease. IRoot BP,MTA and zinc oxide were used as the apical filling materials, and the X-ray and pathological tissue sections were compared 6 months after operation. Evaluate the efficacy of the three. Methods: the mandibular second, third and fourth premolars of 4 beagle dogs were induced to form experimental periapical periodontitis by routine root canal therapy. 48 root canals were randomly divided into 3 groups with 16 root canals in each group. The groups were as follows: control group: zinc oxide was the reverse filling material 1:MTA was the reverse filling material 2:iRoot BP was the reverse filling material 6 months after operation. Histopathological sections of periapical tissue specimens were obtained by HE staining, and the curative effects of zinc oxide iRoot BP and MTA were evaluated. Results six months after operation, the success rate was 81.2%. The results of X-ray showed that there was no significant difference between the control group (81.2%) and the iRoot group (93.810%). The histopathological results showed that there was no significant difference among the three groups. The results of histopathological sections showed that the ratio of zinc oxide in the two groups was higher than that in the control group (P < 0.05), and that in the control group was higher than that in the control group (P < 0.05). Mild inflammation, There was no significant difference in the number of inflammatory cells between the BP group and the MTA group. The bone deposition rate of the MTA group and iRoot BP group was higher than that of the zinc oxide group. Conclusion the results of the X-ray film showed that it was used as a filling material. The results of histopathology showed that the three materials could promote the regeneration of periapical hard tissue. IRoot BP and MTA had the best biocompatibility to the inflammatory stimulation of periapical tissue.
【學(xué)位授予單位】：天津醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2016
【分類號(hào)】：R781.34

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