發(fā)布時(shí)間：2018-07-25 06:34

【摘要】：目的:系統(tǒng)評價(jià)左旋咪唑單獨(dú)用藥及聯(lián)合中藥治療復(fù)發(fā)性阿弗他口腔潰瘍的有效性和安全性。方法:計(jì)算機(jī)檢索Cochrane圖書館、PubMed、CNKI、萬方數(shù)據(jù)庫在線知識服務(wù)平臺,納入有關(guān)左旋咪唑及聯(lián)合中藥治療復(fù)發(fā)性阿弗他口腔潰瘍的隨機(jī)對照試驗(yàn),根據(jù)Cochrane Reviewer’s Handbook 5.0.2評價(jià)標(biāo)準(zhǔn)和工具對納入的研究進(jìn)行質(zhì)量評價(jià),并使用RevMan5.2軟件進(jìn)行統(tǒng)計(jì)分析。結(jié)果:左旋咪唑單獨(dú)用藥共納入9個(gè)隨機(jī)對照試驗(yàn),共331例患者,治療組有效性高于安慰劑組,其差異具有統(tǒng)計(jì)學(xué)意義(OR=4.92,95%CI[2.14,11.32],P=0.0002),共有46例患者出現(xiàn)不良反應(yīng)。左旋咪唑聯(lián)合中藥共納入16個(gè)隨機(jī)對照試驗(yàn),共1854例患者,治療組RAU的有效性明顯高于對照組,其差異具有統(tǒng)計(jì)學(xué)意義(OR=5.97,95%CI[4.40,8.10],P0.00001),無不良反應(yīng)報(bào)道。結(jié)論:左旋咪唑聯(lián)合中藥用于復(fù)發(fā)性阿弗他口腔潰瘍較單獨(dú)采用左旋咪唑效果更好,并且避免了左旋咪唑單獨(dú)用藥副作用大的缺點(diǎn),具有較好的臨床研究和運(yùn)用前景。但本系統(tǒng)評價(jià)納入研究文獻(xiàn)質(zhì)量較差,增加了本次系統(tǒng)評價(jià)結(jié)論產(chǎn)生偏倚的風(fēng)險(xiǎn),期待有高質(zhì)量的臨床試驗(yàn)報(bào)道。
[Abstract]:Objective: to evaluate the efficacy and safety of levamisole alone and traditional Chinese medicine in the treatment of recurrent aphthous ulcer. Methods: the online knowledge service platform of Cochrane Library (Cochrane Library) was searched to study the efficacy of levamisole and traditional Chinese medicine in the treatment of recurrent aphthous ulcer. According to the Cochrane Reviewer's Handbook 5.0.2 evaluation criteria and tools, the quality of the included research was evaluated, and the statistical analysis was carried out with RevMan5.2 software. Results: levamisole alone was used in 9 randomized controlled trials (331 patients). The efficacy of the treatment group was higher than that of the placebo group, and the difference was statistically significant (ORV 4.92 鹵95CI [2.14 鹵11.32] P 0.0002), and 46 patients had adverse reactions. A total of 16 randomized controlled trials were conducted with levamisole combined with Chinese herbal medicine. The efficacy of RAU in the treatment group was significantly higher than that in the control group. The difference was statistically significant (OR5.97 ~ 95CI [4.408.10] P 0.00001), and no adverse reactions were reported. Conclusion: levamisole combined with traditional Chinese medicine is more effective than levamisole alone in the treatment of recurrent aphthous ulcer, and it can avoid the disadvantages of side effects of levamisole alone. It has good clinical research and application prospect. However, the quality of the systematic evaluation is poor, which increases the risk of bias in the conclusion of this systematic evaluation, and looks forward to a high quality clinical trial report.
【作者單位】： 廣東藥學(xué)院中藥學(xué)院;廣州醫(yī)科大學(xué)口腔學(xué)院;廣州白云山和記黃埔中藥有限公司;廣州醫(yī)藥研究總院;
【基金】：廣州市“121人才梯隊(duì)工程”專項(xiàng)資金資助項(xiàng)目(穗人社發(fā)[2011]167號)
【分類號】：R781.5

【參考文獻(xiàn)】

相關(guān)期刊論文 前10條

1 陳傳耀;;中西醫(yī)結(jié)合療法治療口腔潰瘍54例療效觀察[J];西部中醫(yī)藥;2012年07期

2 孫義梅;;黏膜方聯(lián)合左旋咪唑治療復(fù)發(fā)性口腔潰瘍的臨床分析[J];當(dāng)代醫(yī)學(xué);2013年20期

3 商繼仲;張燕;劉占文;;中藥和左旋咪唑聯(lián)合治療復(fù)發(fā)性口腔潰瘍的療效觀察[J];上�？谇会t(yī)學(xué);2010年03期

4 李W，

本文編號：2142945