發(fā)布時(shí)間：2018-05-18 04:35

  本文選題：脫鈣異體凍干骨 + 富血小板血漿��； 參考：《華西口腔醫(yī)學(xué)雜志》2017年06期

【摘要】：目的系統(tǒng)評(píng)價(jià)脫鈣異體凍干骨(DFDBA)聯(lián)合富血小板衍生物治療牙周病導(dǎo)致的骨內(nèi)缺損的有效性。方法在Pub Med、Web of Science、Embase、Cochrane Library、中國(guó)學(xué)術(shù)期刊網(wǎng)全文數(shù)據(jù)庫(kù)等數(shù)據(jù)庫(kù)中檢索2016年5月之前發(fā)表的關(guān)于DFDBA聯(lián)合富血小板衍生物治療牙周病導(dǎo)致的骨內(nèi)缺損的臨床隨機(jī)對(duì)照研究(RCT)。對(duì)納入的文獻(xiàn)研究進(jìn)行質(zhì)量評(píng)價(jià)。應(yīng)用Rev Man 5.3軟件進(jìn)行Meta分析。結(jié)果 9篇RCT文獻(xiàn)納入Meta分析,共194例患者,303個(gè)位點(diǎn)。Meta分析結(jié)果顯示:DFDBA聯(lián)合富血小板衍生物試驗(yàn)組較對(duì)照組可以降低短期組(6個(gè)月)和長(zhǎng)期組(12~18個(gè)月)的牙周袋探診深度,均數(shù)差(MD)分別為0.75 mm[95%可信區(qū)間(CI)(0.31 mm,1.20 mm),P=0.001 0]、0.87 mm[95%CI(0.02 mm,1.72 mm),P=0.04];增加短期組(6個(gè)月)和長(zhǎng)期組(12~18個(gè)月)的臨床附著水平,MD分別為0.65 mm[95%CI(0.08 mm,1.22 mm),P=0.03]、1.31 mm[95%CI(0.60 mm,2.01 mm),P=0.000 3];減少長(zhǎng)期組(12~18個(gè)月)的牙齦退縮[MD為-0.58 mm,95%CI(-0.78 mm,-0.38 mm),P0.000 01];增加短期組(6個(gè)月)和長(zhǎng)期組(12~18個(gè)月)的骨充填高度,MD分別為0.52 mm[95%CI(0.03 mm,1.00 mm),P=0.04]、1.26 mm[95%CI(0.65 mm,1.86 mm),P=0.000 1]。結(jié)論 DFDBA聯(lián)合富血小板衍生物能有效治療牙周病導(dǎo)致的骨內(nèi)缺損,效果優(yōu)于單用組。但因?yàn)榇舜渭{入研究較少,質(zhì)量不高且樣本量較小,所以仍需高質(zhì)量的、大樣本的RCT來(lái)進(jìn)一步驗(yàn)證。
[Abstract]:Objective to evaluate the effectiveness of decalcified allogenic freeze-dried bone (DFDBA) combined with platelet rich derivatives in the treatment of intraosseous defects caused by periodontitis. Methods in the database of Pub Med, Web of Science, Embase, Cochrane Library, Chinese academic journal full text database, and other databases published before May 2016 on DFDBA combined with platelet rich derivatives A randomized controlled study (RCT) for the treatment of intraosseous defects caused by periodontitis. Quality evaluation of the included literature study. Meta analysis was carried out with Rev Man 5.3 software. Results 9 RCT literature included Meta analysis in 194 patients and 303 loci.Meta analysis showed that DFDBA combined with platelet rich test group was better than control group To reduce the depth of periodontal pocket detection in the short-term group (6 months) and the long-term group (12~18 months), the mean number difference (MD) was 0.75 mm[95% confidence interval (CI) (0.31 mm, 1.20 mm), P=0.001 0], 0.87 mm[95%CI (0.02 mm, 1.72 mm), P=0.04], and the clinical attachment level of the short-term group (6 months) and the long-term group (0.08, 0.08, 1, respectively). .22 mm), P=0.03], 1.31 mm[95%CI (0.60 mm, 2.01 mm), P=0.000 3]; reducing the gingival retraction of the long-term group (12~18 months) [MD for -0.58 mm, increases the bone filling height of the short-term group (6 months) and the long-term group (1, 1, 1), 1.26, 1.86, 1.86 P=0.000 1]. conclusion that DFDBA combined with platelet rich derivatives can effectively treat periodontal disease caused by intraosseous defects, which is better than the single use group. But because of the less study, low quality and small sample size, high quality and large sample RCT are still needed to further verify.
【作者單位】： 遵義市正安縣人民醫(yī)院口腔科;重慶醫(yī)科大學(xué)附屬口腔醫(yī)院牙體牙髓科;口腔疾病與生物醫(yī)學(xué)重慶市重點(diǎn)實(shí)驗(yàn)室;重慶市高校市級(jí)口腔生物醫(yī)學(xué)工程重點(diǎn)實(shí)驗(yàn)室;
【基金】：重慶市衛(wèi)生局醫(yī)學(xué)科研重點(diǎn)項(xiàng)目(2012-1-053)~~
【分類號(hào)】：R781.4

【相似文獻(xiàn)】

相關(guān)期刊論文 前10條

1 秦剛;王秋旭;劉維賢;;MTHFR基因多態(tài)性與非綜合征性唇腭裂易感性關(guān)系Meta分析[J];中國(guó)實(shí)用兒科雜志;2013年11期

2 哈麗婭;趙今;劉弈杉;鐘良軍;;牙周炎與絕經(jīng)后骨質(zhì)疏松癥相關(guān)性的Meta分析[J];中國(guó)循證醫(yī)學(xué)雜志;2011年12期

3 辛蔚妮,凌均h，

本文編號(hào)：1904412