本文選題：介孔硅 + 糞腸球菌�。� 參考：《口腔醫(yī)學(xué)研究》2017年12期

【摘要】：目的:探討氨基改性前后的介孔硅載七葉皂苷鈉(SA-SBA-15及SA-NH_2-SBA-15)和氫氧化鈣Ca(OH)_2對糞腸球菌的抑菌作用。方法:液體稀釋法測SA-NH_2-SBA-15、SA-SBA-15和Ca(OH)_2的最低抑菌濃度(MIC);液體擴(kuò)散法觀察SA-NH_2-SBA-15、SA-SBA-15和Ca(OH)_2對糞腸球菌抑菌圈的大小;SA-NH_2-SBA-15、SA-SBA-15和Ca(OH)_2與菌液共培養(yǎng)168h,每隔24h取0.1mL液體另作厭氧培養(yǎng)24h,評價(jià)抑菌效果。結(jié)果:SA-NH_2-SBA-15、SA-SBA-15的MIC為3.5g/L,Ca(OH)_2的MIC為4.0g/L。SA-NH_2-SBA-15、SA-SBA-15和Ca(OH)_2濃度大于MIC時(shí),抑菌圈大小與濃度呈依賴性增高,差異具有統(tǒng)計(jì)學(xué)意義(P0.05)。72h后至168h,SA-SBA-15和SA-NH_2-SBA的菌落數(shù)明顯少于Ca(OH)_2。96h后,SA-NH_2-SBA-15組的菌落數(shù)明顯少于SA-SBA-15組,差異具有統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論:SA-NH_2-SBA-15、SA-SBA-15及Ca(OH)_2對糞腸球菌具有一定的抗菌作用;SA-NH_2-SBA-15、SA-SBA-15的抑菌效果優(yōu)于Ca(OH)_2;SA-NH_2-SBA-15對糞腸球菌的藥效長于SA-SBA-15,長于Ca(OH)_2。
[Abstract]:Aim: to investigate the bacteriostatic effects of sodium aescinate sodium (SA-SBA-15 and SA-NH2-SBA-15) and calcium hydroxide (Ca(OH)_2) on Enterococcus faecalis before and after amino modification. Methods: the minimum inhibitory concentrations of SA-NH2-SBA-15 SA-SBA-15 and Ca(OH)_2 were measured by liquid dilution method, and the size of SA-NH2-SBA-15 SA-SBA-15 and Ca(OH)_2 on Enterococcus faecalis were observed by liquid diffusion method. Results the number of colony of SA-SBA-15 and SA-SBA-15 of SA-SBA-15 was significantly lower than that of SA-NH2-SBA-15 and SA-NH2-SBA-15 of SA-SBA-15, the number of colony of SA-SBA-15 and SA-NH_2-SBA of SA-NH2-SBA-15 and SA-NH2-SBA-15 were significantly lower than those of SA-NH2-SBA-15 after Ca(OH)_2.96h, and the number of SA-SBA-15 and SA-NH_2-SBA in SA-NH2-SBA-15 group were significantly lower than those in SA-SBA-15 group, and the number of SA-SBA-15 and SA-NH_2-SBA in SA-NH2-SBA-15 group was significantly lower than that in SA-SBA-15 group. The difference was statistically significant (P 0.05). Conclusion the antibacterial activity of SA-NH2-SBA-15 and Ca(OH)_2 against Enterococcus faecalis is better than that of CaOHS-2SA-NH2-SBA-15 on Enterococcus faecalis and longer than that on CaOHA-15 and CaOHA-15 on Enterococcus faecalis (SA-SBA-15) and CaOHA-15 (CaOHA-15) on Enterococcus faecalis. The antibacterial effect of SA-NH2-SBA-15 and Ca(OH)_2 on Enterococcus faecalis is better than that on CaOHA-15 and SA-NH2-SBA-15 on Enterococcus faecalis.
【作者單位】： 廈門市婦幼保健院口腔科;中南大學(xué)湘雅口腔醫(yī)學(xué)院;廈門大學(xué)附屬中山醫(yī)院口腔科;
【分類號】：R781.05

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