本文選題：Biodentine + MTA　； 參考：《南方醫(yī)科大學(xué)》2017年碩士論文

【摘要】：研究背景Biodentine是基于MTA改良成的牙本質(zhì)修復(fù)材料。Biodentine具有良好的封閉性能,可促進(jìn)組織修復(fù)再生。研究表明,Biodentine還可作為充填物形成HA,滲透入牙本質(zhì)小管,與牙本質(zhì)接觸形成機(jī)械固位,減少微滲漏,防止再感染。但Biodentine作為充填物在小管中的滲透程度及對(duì)牙本質(zhì)抗折影響的研究較少。根管充填整體化(monoblock)代表著根管治療新趨勢(shì),monoblock強(qiáng)調(diào)充填的封閉性及材料的流動(dòng)性使其滲入小管形成微機(jī)械固位,增強(qiáng)牙根抗折性。而作為充填物,在實(shí)現(xiàn)充填整體化中起重要作用。綜上,Biodentine可能會(huì)影響牙本質(zhì)抗折性。本實(shí)驗(yàn)擬比較探究Biodentine與MTA存在于根管內(nèi)的滲透程度及其對(duì)牙本質(zhì)抗折性的影響。研究目的本實(shí)驗(yàn)擬建立Biodentine與MTA充填于根管內(nèi)的體外模型,比較材料在牙本質(zhì)小管中滲透程度及牙本質(zhì)抗折性。材料與方法第一部分Biodentine滲透入牙本質(zhì)小管中的掃描電鏡觀察收集離體牙45顆,分成三組:Biodentine組;MTA組和Vitapex組,每組15顆。充填物充填根管。三個(gè)月后取標(biāo)本距根尖1mm與5mm處橫截面。電鏡下記錄材料滲透深度,分析結(jié)果。第二部分Biodentine在牙本質(zhì)小管中滲透深度最大值及滲透面積百分比的研究收集60顆離體牙,分成四組:對(duì)照組;Biodentine組;MTA組和Vitapex組。藥物熒光標(biāo)記后充填根管。三個(gè)月后取標(biāo)本距根尖lmm與5mm處組織,LSCM下觀察。計(jì)算藥物在1mm與5mm處的滲透深度最大值和滲透面積百分比,分析結(jié)果。第三部分Biodentine對(duì)牙本質(zhì)三點(diǎn)彎曲強(qiáng)度及彎曲模量影響的初步探究收集尖牙48顆,根中部分牙本質(zhì)作為標(biāo)本。符合標(biāo)準(zhǔn)的標(biāo)本共40個(gè),保存?zhèn)溆�。�?biāo)本分為5組,每組8顆。A組為陽(yáng)性對(duì)照組,不作處理;余四組均拔髓。其中B組不做充填;C、D、E組分別充填Biodentine、MTA、Vitapex。標(biāo)本保存三個(gè)月后行力學(xué)測(cè)試。結(jié)果1.距根尖1mm與5mm處各材料滲透深度最大值均值差異具顯著統(tǒng)計(jì)意義:距根尖5mm處各材料滲透深度最大值均值明顯大于lmm處且滲透分布更均勻;Biodentine和MTA在距根尖5mm處滲透深度最大值差異無(wú)統(tǒng)計(jì)意義。2.距根尖5mm處各材料滲透面積百分比均值明顯大于1mm處;距根尖1mm處各材料滲透面積百分比差異無(wú)統(tǒng)計(jì)意義;距根尖5mm處Biodentine與MTA滲透面積百分比均值分別78.8%、72.3%,差異具統(tǒng)計(jì)學(xué)意義。3.A組分別與B、D、E組間標(biāo)本三點(diǎn)彎曲強(qiáng)度差異具統(tǒng)計(jì)意義;C組與D組相比,標(biāo)本三點(diǎn)彎曲強(qiáng)度差異無(wú)統(tǒng)計(jì)意義。4.標(biāo)本彎曲模量差異除了C組與D組無(wú)統(tǒng)計(jì)意義外,其他組間差異均具統(tǒng)計(jì)意義。結(jié)論1.成功建立Biodentine與MTA充填于根管內(nèi)的體外模型。2.三種材料微粒密集附著于牙本質(zhì)小管中及管周表面,小管未見(jiàn)破壞腐蝕。但Biodentine、MTA部分微粒滲入膠原纖維間,且Vitapex滲透深度明顯不及Biodentine 與 MTA。3.距根尖5mm處各材料滲透深度最大值均值與滲透面積百分比均值明顯大于 1mm處。4.Biodentine和MTA對(duì)牙本質(zhì)抗折性的影響無(wú)統(tǒng)計(jì)差異。
[Abstract]:Background Biodentine is a modified dentin repair material based on MTA. Biodentine has good sealing performance and can promote tissue regeneration. The results showed that Biodentine could also be used as a filling material to form HA, infiltrate into dentin tubules, form mechanical retainer in contact with dentin, reduce microleakage and prevent re-infection. However, there are few studies on the permeability of Biodentine in the tubules and the effect of Biodentine on dentin fracture. Monoblock represents a new trend of root canal therapy. It emphasizes the sealing of filling and the fluidity of materials, which makes it infiltrate into the tubules to form micromechanical retainers and enhance the root fracture resistance. As a filling material, it plays an important role in the realization of filling integration. Biodentine may affect dentin fracture resistance. The purpose of this study was to compare the osmotic degree of Biodentine and MTA in root canal and its effect on dentin fracture. Objective to establish an in vitro model of Biodentine and MTA filling in root canals and compare the osmotic degree and dentin fracture resistance of the materials in dentine tubules. Materials and methods in part one, 45 teeth were collected by scanning electron microscope (SEM) after Biodentine permeated into dentine tubules. 45 teeth were divided into three groups, one group was divided into three groups: Biodentine group (n = 15) and Vitapex group (n = 15). The filling fills the root canal. Three months later, the cross section between 1mm and 5mm was taken. The penetration depth of the material was recorded under electron microscope and the results were analyzed. In the second part, the maximum osmotic depth and the percentage of osmotic area in dentine tubules were collected and 60 teeth were divided into four groups: control group, Biodentine group and Vitapex group. The root canal was filled with drug fluorescence labeling. After 3 months, the specimens were observed under lmm and 5mm. The maximum osmotic depth and the percentage of osmotic area at 1mm and 5mm were calculated and the results were analyzed. The third part: the effect of Biodentine on the three-point bending strength and flexural modulus of dentin. 48 canine teeth were collected and some dentin in the root were taken as specimens. A total of 40 specimens that meet the standards are preserved and reserved. The specimens were divided into 5 groups, 8 in each group were positive control group, untreated, and the other four groups were pull-out. Group B was not filled with Biodentine MTAA Vitapex. After three months of preservation, the specimens were subjected to mechanical tests. Result 1. Significant statistical significance was found in the difference of the mean value of the maximum osmotic depth between 1mm and 5mm: the mean value of the maximum osmotic depth of each material from 5mm to the root tip was significantly larger than that from lmm, and the osmotic distribution was more uniform. Biodentine and MTA permeated at 5mm from the root tip. The difference of maximum penetration depth has no statistical significance. The percentage of osmotic area from 5mm to root tip was significantly higher than that from 1mm, and there was no statistical significance between the percentage of osmotic area from root tip 1mm and that from root tip 1mm. The average osmotic area of Biodentine and MTA from the root tip of 5mm was 78.80.The difference was statistically significant. 3.The difference of three-point bending strength between group A and group E was statistically significant. There was no significant difference in three-point bending strength between group C and group D. Except group C and group D, the difference of flexural modulus was statistically significant. Conclusion 1. The in vitro model of Biodentine and MTA filling in root canal was established successfully. The three kinds of material particles were attached to the dentine tubules and the surface around the tubules. The tubules were not damaged and corroded. However, some particles of Biodentine Vitapex infiltrated between collagen fibers, and the penetration depth of Vitapex was significantly lower than that of Biodentine and MTA. 3. The mean value of maximum osmotic depth and the percentage of osmotic area from 5mm to root tip were significantly higher than those from 1mm. 4. There was no statistical difference in the effect of Biodentine and MTA on dentin fracture.
【學(xué)位授予單位】：南方醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R781.05

【參考文獻(xiàn)】

相關(guān)期刊論文 前2條

1 Grégory Caron;Jean Azérad;Marie-Odile Faure;Pierre Machtou;Yves Boucher;;Use of a new retrograde filling material(Biodentine) for endodontic surgery: two case reports[J];International Journal of Oral Science;2014年04期

2 朱文昊;王世明;張成飛;;無(wú)機(jī)三氧化復(fù)合物修補(bǔ)髓室底和根管穿孔的臨床效果[J];實(shí)用口腔醫(yī)學(xué)雜志;2007年03期

，

本文編號(hào)：1820049