本文選題：酸蝕癥 + 奧威爾�。� 參考：《華北理工大學》2015年碩士論文

【摘要】：目的本實驗主要通過離體牙的體外實驗,觀察奧威爾牙齒脫敏劑、多樂氟、碳酸氫鈉礦化液對早期釉質酸蝕癥再礦化及抗酸能力的影響,從而探索出一種再礦化及抗酸效果均較好的制劑,為臨床上預防和治療早期牙釉質脫礦提供有力的實驗依據。方法選擇華北理工大學博創(chuàng)口腔醫(yī)院頜面外科拔除的無齲后牙60顆,制備成4mm×4mm的釉質樣本120個,隨機分為8組,每組15個。①再礦化實驗:釉質標本經可口可樂浸泡脫礦后再用奧威爾牙齒脫敏劑(A組)、多樂氟(B組)、碳酸氫鈉礦化液(C組)、去離子水對照組(D組)局部處理7天;②抗酸實驗:經奧威爾牙齒脫敏劑(E組)、多樂氟(F組)、碳酸氫鈉礦化液(G組)、去離子水對照組(H組)局部處理7天后,再經可口可樂浸泡脫礦。兩組實驗均應用掃描電鏡、原子力顯微鏡、X射線能譜儀、顯微硬度計進行檢測,從釉質表面形態(tài)、顯微結構、粗糙度、無機物含量和顯微硬度等方面進行結果分析,評估三種藥物對釉質的再礦化和抗酸能力。③采用SPSS17.0單因素方差分析對各組數據進行兩兩比較。結果1.掃描電鏡觀察結果:再礦化實驗后,A、B、C各組均有礦物質沉積于釉質表面凹陷內,D組無明顯變化;抗酸實驗后,E、F、G、H各組釉質表面出現不同程度的破壞,H組脫礦凹陷明顯。2.原子力顯微鏡觀測結果:再礦化實驗后,A、B、C組釉質表面呈現不同形態(tài)礦物質沉積,A組沉積物較另兩組更規(guī)則明顯,但D組仍呈典型釉質脫礦表現,A組凹陷深度顯著小于B、C、D組(P0.05),A、B組粗糙度顯著小于C、D組(P0.05),但A、B組間無明顯差異(P0.05);抗酸實驗后,E、F、G、H各組釉質表面出現不同程度的脫礦凹陷,E組凹陷明顯淺于其他三組(P0.05),E、F組粗糙度明顯小于G、H組(P0.05),但E、F組間無明顯差異(P0.05)。3.能譜分析結果:再礦化實驗后,A組的Ca2+、P3+含量都高于其他實驗組(P0.05),但各組間Ca/P無明顯差異(P0.05);抗酸實驗后,E組的Ca2+、P3+含量高于其它實驗組(P0.05),F組Ca/P明顯低于E組(P0.05),而其他三組見未見明顯差異(P0.05)。4.釉質表面顯微硬度變化:再礦化實驗和抗酸實驗后,奧威爾牙齒脫敏劑組(A、E組)的顯微硬度均優(yōu)于實驗中其他各組(P0.05)。結論1奧威爾牙齒脫敏劑、多樂氟和碳酸氫鈉礦化液三種藥物均可促進釉質再礦化、提高釉質抗酸能力。2經奧威爾牙齒脫敏劑、多樂氟處理后的釉質表面粗糙度相似。3奧威爾牙齒脫敏劑在促進釉質再礦化和提高釉質抗酸能力的方面均優(yōu)于多樂氟和碳酸氫鈉再礦化液。
[Abstract]:Objective to observe the effects of Orwell's tooth desensitizer, dolafur and sodium bicarbonate on the remineralization and anti-acid ability of early enamel acid etching.Thus, a new preparation with good effect of remineralization and acid resistance was developed, which provides a powerful experimental basis for clinical prevention and treatment of early enamel demineralization.Methods A total of 60 caries-free posterior teeth were extracted from maxillofacial surgery in Bochuang Oral Hospital of North China University of Science and Technology. 120 enamel samples of 4mm 脳 4mm were prepared and randomly divided into 8 groups.The enamel samples were treated with Orwell tooth desensitizer group A, Dorafur group B, sodium bicarbonate group C, deionized water group D) for 7 days.2 Anti-acid experiment: after 7 days of local treatment with Orwell's tooth desensitizer group E, Dorafur group F, sodium bicarbonate group G, deionized water control group (H group) for 7 days, then decalcified with Coca Cola.Scanning electron microscope, atomic force microscope (AFM) X-ray spectrometer and microhardness meter were used to test the results of the two groups of experiments. The results were analyzed from the aspects of enamel surface morphology, microstructure, roughness, inorganic content and microhardness.To evaluate the remineralization and acid resistance of three drugs to enamel. 3 the data of each group were compared by SPSS17.0 univariate ANOVA.Result 1.The results of scanning electron microscope observation showed that there was no obvious change of mineral deposit in group D in enamel surface depression after remineralization test, but there was different degree of destruction on enamel surface in each group after acid resistance test. The demineralization depression of group H was obvious.Atomic force microscope (AFM) observation: after the remineralization experiment, the enamel surface of group A was more regular than that of the other two groups, and the surface of enamel in group A was more regular than that in group A with different forms of mineral deposits.However, typical demineralization of enamel in group D showed that the depth of depression in group A was significantly lower than that in group B (P 0.05), but the roughness of group B was significantly lower than that of group C (D), but there was no significant difference between group A and B (P 0.05A).The roughness of E group was obviously lower than that of other three groups. The roughness of group F was obviously lower than that of group G H, but there was no significant difference between group E and group F (P 0.05 路3).The results of energy spectrum analysis showed that the content of Ca2 P 3 in group A was higher than that in other experimental groups, but there was no significant difference in Ca/P between groups, and the content of Ca2 P 3 3 in group E was significantly higher than that in group F (P 0.05), but the content of Ca/P in group E was significantly lower than that in group E (P 0.05).In the other three groups, there was no significant difference (P 0.05. 4).The changes of surface microhardness of enamel: the microhardness of Orwell's tooth desensitizer group was better than that of other groups (P 0.05) after remineralization test and acid resistance test.Conclusion (1) Orwell's tooth desensitizer, dolafur and sodium bicarbonate can promote enamel remineralization and improve enamel's acid-resistant ability by orwell's tooth desensitizer.The surface roughness of enamel treated with dollofluoride was similar. 3. 3. Orwell tooth desensitizer was superior to Dorafur and sodium bicarbonate in promoting enamel remineralization and improving enamel acid resistance.
【學位授予單位】：華北理工大學
【學位級別】：碩士
【學位授予年份】：2015
【分類號】：R781.1

【參考文獻】

相關期刊論文 前9條

1 高晉華,杜民權,臺保軍;牙齒酸蝕癥[J];國外醫(yī)學.口腔醫(yī)學分冊;2005年05期

2 李文卿;趙瑋;;控制牙齒酸蝕癥的研究進展[J];國際口腔醫(yī)學雜志;2008年04期

3 陳鯤;阮金云;易多宗;楊發(fā)成;藍海;;五倍子與沒食子提取物對人工脫礦釉質再礦化的研究[J];大理學院學報;2012年09期

4 李彩;周學東;;五倍子在齲病防治中的研究進展[J];華西醫(yī)學;2006年02期

5 呂雪芹;朱玲;;早期平滑面齲再礦化初探[J];口腔醫(yī)學研究;2007年05期

6 吳娜;周學東;郝玉慶;;氟對脫礦和再礦化牙釉質表面的影響[J];華西口腔醫(yī)學雜志;2012年05期

7 李淑慧;吳佩玲;;酪蛋白磷酸多肽-無定形磷酸鈣在口腔治療中的研究應用[J];牙體牙髓牙周病學雜志;2011年10期

8 劉振華;王鐸;賀長歷;;硅對人恒前磨牙早期釉質齲再礦化影響的掃描電鏡觀察[J];中華老年口腔醫(yī)學雜志;2011年02期

9 邵若蘅;;奧威爾脫敏劑對幼兒牙釉質發(fā)育不全的臨床療效觀察[J];中國醫(yī)藥指南;2013年10期

，

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