本文選題：口腔鱗癌 + 淋巴管密度　； 參考：《北京協(xié)和醫(yī)學院》2014年碩士論文

【摘要】：目的： 觀察口腔鱗癌中淋巴管生成情況,分析口腔鱗癌的瘤內(nèi)和瘤周淋巴管密度及腫瘤浸潤深度等臨床病理指標與腫瘤頸淋巴結(jié)轉(zhuǎn)移的相關(guān)性。 方法： 采用免疫組化SP法檢測69例口腔鱗癌Ki-67、D2-40,分析瘤內(nèi)和瘤周淋巴管密度,以及腫瘤浸潤深度,結(jié)合臨床病理因素分析其與頸部淋巴結(jié)轉(zhuǎn)移的相關(guān)性。 結(jié)果： 1.總的“熱點”平均淋巴管密度為11.2個／HPF。淋巴管密度在牙齦癌瘤內(nèi)增大與淋巴轉(zhuǎn)移組和非轉(zhuǎn)移組間有明顯相關(guān)性；與舌癌淋巴結(jié)轉(zhuǎn)移之間顯著相關(guān)(P=-0.011)。 2.高分化口腔癌中Ki-67的陽性表達率瘤內(nèi)、瘤周之間有顯著的表達差異(P0.0001),瘤內(nèi)較瘤周明顯高表達�？谇话┝馨娃D(zhuǎn)移與Ki-67免疫組化陽性表達未發(fā)現(xiàn)明顯相關(guān)性。 3.舌癌、口底癌中腫瘤浸潤深度與頸淋巴結(jié)轉(zhuǎn)移有顯著正相關(guān)性。 結(jié)論： 1.本研究發(fā)現(xiàn)腫瘤的浸潤深度與舌癌、口底鱗癌的頸淋巴結(jié)轉(zhuǎn)移呈明顯正相關(guān)；當腫瘤浸潤深度≥5mm時,臨床中應考慮選擇頸淋巴結(jié)清掃。 2.在牙齦癌中,腫瘤的瘤內(nèi)淋巴管密度在有淋巴結(jié)轉(zhuǎn)移組和無淋巴結(jié)轉(zhuǎn)移組中有顯著統(tǒng)計學差異。淋巴管密度及腫瘤浸潤深度是舌癌、口底癌發(fā)生淋巴轉(zhuǎn)移的重要風險因素。 3.Ki-67對判斷牙齦癌分化程度有一定參考價值。
[Abstract]:Objective:To observe the lymphangiogenesis in oral squamous cell carcinoma (OSCC) and to analyze the correlation between lymphatic vessel density and depth of tumor invasion in oral squamous cell carcinoma (OSCC) and cervical lymph node metastasis.Methods:Immunohistochemical SP method was used to detect Ki-67D2-40 in 69 cases of oral squamous cell carcinoma (OSCC). The density of lymphatic vessels in and around the tumor and the depth of tumor invasion were analyzed. The correlation between Ki-67D2-40 and cervical lymph node metastasis was analyzed with clinicopathological factors.Results:1.The mean total "hot spot" lymphatic vessel density was 11.2 / HPF.There was a significant correlation between lymphatic vessel density in gingival carcinomas and lymph node metastasis and tongue cancer lymph node metastasis.2.The positive expression rate of Ki-67 in well-differentiated oral carcinoma was significantly higher than that in the surrounding tumor (P 0.0001).There was no significant correlation between lymphatic metastasis and Ki-67 immunohistochemical expression in oral carcinoma.3.There was a significant positive correlation between the depth of tumor invasion and cervical lymph node metastasis in tongue and floor carcinoma.Conclusion:1.This study found that the depth of tumor invasion was positively correlated with the cervical lymph node metastasis of tongue cancer and squamous cell carcinoma of the floor of mouth, and when the depth of tumor invasion was 鈮，

本文編號：1754778