【摘要】：目的探討血清BDNF與尿AD7c-NTP聯(lián)合檢測對輕度認知功能障礙(MCI)進展為阿爾茨海默病的預測價值。方法收集172例MCI患者(MCI組)及90例健康者(正常對照組)基線、12 m、24 m的血清BDNF和尿AD7c-NTP的表達水平。結(jié)果 MCI患者血清BDNF水平在基線、12 m、24 m顯著低于同期對照組(P0.05),而尿AD7c-NTP水平在基線、12 m、24 m顯著高于同期對照組(P0.01)。此外,32例MCI患者于隨訪的2y中進展為AD(MCI-AD組),其血清BDNF水平在基線、12 m、24 m顯著低于穩(wěn)定型MCI患者(MCI-ST組),而尿AD7c-NTP水平在基線、12 m、24 m顯著高于穩(wěn)定型MCI患者。結(jié)論血清BDNF與尿AD7c-NTP聯(lián)合檢測是鑒別及診斷MCI進展為AD的較好指標,提升二者單獨應用時的預測價值。
[Abstract]:Objective To study the predictive value of serum BDNF and ADc-NTP combined to detect the progression of mild cognitive impairment (MCI) to Alzheimer's disease. Methods The expression levels of BDNF and ADc-NTP in 172 patients with MCI and 90 healthy subjects (normal control group) were collected from baseline,12 m and 24 m. Results The level of BDNF in the patients with MCI was significantly lower than that of the control group at baseline, 12m, and 24m (P0.05), while the level of the ADc-NTP in the urine was significantly higher than that in the control group (P0.01). In addition,32 patients with MCI had progressed to AD (MCI-AD group) in 2y of follow-up, with serum BDNF levels at baseline,12 m, and 24 m significantly lower than those of stable MCI (MCI-ST group), while the urinary ADc-NTP levels were significantly higher than those of stable MCI at baseline,12 m, and 24 m. Conclusion The combined detection of serum BDNF and ADc-NTP is a good index for the identification and diagnosis of MCI.
【作者單位】： 哈勵遜國際和平醫(yī)院醫(yī)務處;哈勵遜國際和平醫(yī)院中心實驗室;哈勵遜國際和平醫(yī)院神經(jīng)內(nèi)科二病區(qū);
【基金】：河北省2013年醫(yī)學科學研究課題計劃(No.20130345)
【分類號】：R749.16

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