【摘要】：目的：利用腦電超慢漲落技術(shù)，檢測住院網(wǎng)絡(luò)成癮青少年腦內(nèi)神經(jīng)遞質(zhì)的變化，對揭示網(wǎng)絡(luò)成癮的生理因素有一定的幫助，為臨床網(wǎng)絡(luò)成癮的診斷及療效判定提供一些客觀指標。 方法：采用癥狀自評量表對北京軍區(qū)總醫(yī)院符合陶氏網(wǎng)絡(luò)成癮診斷標準的青少年網(wǎng)絡(luò)成癮患者進行測查。然后在網(wǎng)絡(luò)成癮患者接受心理藥物治療前（入院一周之內(nèi)），采用ML2001型腦電超慢漲落分析儀(北京同仁光電技術(shù)公司生產(chǎn))對其進行腦電超慢漲落圖的檢查。完成整個檢查大約需要1個小時。首先將網(wǎng)絡(luò)成癮患者癥狀自評量表的相關(guān)指標與全國青年常模用t檢驗進行統(tǒng)計分析。然后將獲得的腦電信號進行普通腦電圖分析,最后將腦電信號經(jīng)窗口設(shè)置、頻譜分析、優(yōu)勢譜提取、時空精細結(jié)構(gòu)等分析，然后將測試數(shù)據(jù)在計算機上進行轉(zhuǎn)換,用FoxPro6.0數(shù)據(jù)庫軟件進行處理。 結(jié)果：網(wǎng)絡(luò)成癮患者SCL-90量表測查結(jié)果顯示：軀體化、強迫、人際關(guān)系敏感、抑郁、焦慮、敵對、恐怖、偏執(zhí)、精神病性和總均分及陽性項目數(shù)均高于全國青年常模，差異具有統(tǒng)計學意義(P0.05)。網(wǎng)絡(luò)成癮患者的波主波以10Hz為主，波能量主要分布在10Hz上。網(wǎng)絡(luò)成癮患者的腦功能以深抑制為主。網(wǎng)絡(luò)成癮患者腦內(nèi)神經(jīng)遞質(zhì)r-氨基丁酸、多巴胺、5-羥色胺、去甲腎上腺素、谷氨酸的含量顯著低于正常值(P0.05),抑制性遞質(zhì)的含量顯著高于正常值(P0.05)。 結(jié)論：(1)網(wǎng)絡(luò)成癮患者存在強迫、抑郁、焦慮等身心癥狀(2)網(wǎng)絡(luò)成癮患者的腦功能狀態(tài)主要以深抑制為主。(3)網(wǎng)絡(luò)成癮患者的α波有慢化的趨勢。(4)網(wǎng)絡(luò)成癮患者腦內(nèi)的谷氨酸，多巴胺，r-氨基丁酸、5-羥色胺、去甲腎上腺素的含量比正常人低,抑制性遞質(zhì)含量較高。
[Abstract]:Objective: to detect the changes of neurotransmitters in the brain of hospitalized teenagers with Internet addiction by using the ultra-slow fluctuation technique of EEG, which is helpful to reveal the physiological factors of Internet addiction and to provide some objective indexes for the diagnosis and curative effect judgment of Internet addiction in clinic. Methods: symptom Checklist (symptom Checklist) was used to detect the adolescent patients with Internet addiction who met the diagnostic criteria of Dow's Internet addiction in Beijing military region General Hospital. Then the patients with Internet addiction were examined by ML2001 EEG ultra-slow fluctuation analyzer (produced by Beijing Tongren Optoelectronic Technology Company) before receiving psychotherapy (within one week of admission). It takes about an hour to complete the whole inspection. Firstly, the related indexes of symptom Checklist for Internet Addiction patients and the national youth norm were statistically analyzed by t test. Then the obtained EEG signals are analyzed by ordinary electroencephalogram (EEG). Finally, the EEG signals are analyzed by window setting, spectrum analysis, dominant spectrum extraction, space-time fine structure and so on, and then the test data are converted on the computer and processed with FoxPro6.0 database software. Results: the results of SCL- 90 scale in patients with Internet addiction showed that somatization, obsessive-compulsive, interpersonal sensitivity, depression, anxiety, hostility, phobia, paranoid ideation, psychosis, total mean score and the number of positive items were significantly higher than those of the national youth norm (P 0.05). 10Hz is the main wave in patients with Internet addiction, and wave energy is mainly distributed on 10Hz. Deep inhibition is the main brain function in patients with Internet addiction. The contents of neurotransmitters r-aminobutyric acid, dopamine, 5-hydroxytryptamine, norepinephrine and glutamic acid in the brain of patients with Internet addiction were significantly lower than the normal value (P 0.05), and the contents of inhibitory transmitters were significantly higher than the normal value (P 0.05). Conclusion: (1) there are physical and mental symptoms such as obsessive-compulsive, depression, anxiety and so on. (2) the brain function of Internet addicts is mainly deeply suppressed. (3) the 偽 wave of Internet addicts tends to slow down. (4) the contents of glutamic acid, dopamine, raminobutyric acid, 5-hydroxytryptamine and norepinephrine in the brain of Internet addicts are lower than those of normal subjects, and the contents of inhibitory transmitters are higher.
【學位授予單位】：大連醫(yī)科大學
【學位級別】：碩士
【學位授予年份】：2013
【分類號】：R749.99

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