發(fā)布時間：2019-04-08 09:26

【摘要】：目的:研究分析重復經(jīng)顱磁刺激(rTMS)治療精神分裂癥陰性癥狀的療效評估。方法:隨機選取本院精神科患有精神分裂癥患者66例,且均殘留明顯的陰性癥狀�；颊弑浑S機分為兩組,研究組使用高頻rTMS刺激治療,對照組使用rTMS刺激偽治療,兩組患者分別治療為期1個月,并進行1個月隨訪,通過對PANSS、SANS、PRM指標分值測試,對患者臨床癥狀進行分析對比。其中運用的工具為:用于測量PANSS陽性與陰性癥狀量表、成人安全篩查表檢測患者是否可以進行高頻rTMS刺激、測量SANS指標的陰性癥狀量表(SANS)以及對心理、認知功能進行測試的劍橋自動化成套神經(jīng)心理測試等進行臨床評估。對比分析兩組患者治療前后PANSS、SANS、PRM指標的總分評分并對比兩組的療效。結果:治療期間,研究組患者1個月末:(1)SANS評分,即SAF、SVB、SISL、SVB、SPT、及SAD指標較基線期均有所下降,且SANS總分降低;(2)PANSS評分,即POS、NEG、GPS指標較基線期降低,且總分下降;(3)PRM評分,即N、T1、T2指標較基線期較低,差異有統(tǒng)計學意義(P0.05)。對照組患者SANS、PANSS及PRM評分較基線期不明顯變化,差異無統(tǒng)計學意義(P0.05)。隨訪期間,研究組患者2個月末:SANS評分,即SAF、SVB、SISL、SVB、SPT、及SAD指標較1月末均有所下降,且SANS總分降低;(2)PANSS評分,即POS、NEG、GPS指標較1月末降低,且總分下降;(3)PRM評分,即N、T1、T2指標較1月末較低,差異有統(tǒng)計學意義(P0.05)。對照組對照組患者SANS、PANSS及PRM評分較1月末不明顯變化,差異無統(tǒng)計學意義(P0.05)。結論:采用高頻rTMS刺激治療,精神分裂患者陰性癥狀可得到緩解,效果在治療后2個月后較為明顯,并且通過高頻rTMS刺激,可提高患者的認知功能。
[Abstract]:Objective: to evaluate the efficacy of repetitive transcranial magnetic stimulation (rTMS) in the treatment of negative symptoms of schizophrenia. Methods: 66 patients with schizophrenia in our psychiatric department were randomly selected, all of whom had significant negative symptoms. The patients were randomly divided into two groups: the study group was treated with high frequency rTMS stimulation, and the control group was treated with rTMS stimulation false therapy. The patients in the two groups were treated for a period of 1 month and followed up for 1 month. The clinical symptoms of the patients were analyzed and compared. The tools used are: the PANSS positive and negative symptom scale, the adult safety screening table to detect whether patients can be stimulated with high frequency rTMS, the negative symptom scale (SANS) of SANS index, and the psychological control. Cambridge automated neuropsychological tests for cognitive function testing were used for clinical evaluation. The total score of PANSS,SANS,PRM before and after treatment was compared between the two groups and the curative effect was compared between the two groups. Results: at the end of one month after treatment, the patients in the study group were: (1) the SANS score, that is, the indexes of SAF,SVB,SISL,SVB,SPT, and SAD were lower than those in the baseline stage, and the total score of SANS was lower; (2) PANSS score, that is, POS,NEG,GPS index was lower than baseline stage, and total score decreased; (3) PRM score, that is, N, T _ 1, T _ 2 index was lower than baseline stage, the difference was statistically significant (P0.05). There was no significant difference in SANS,PANSS and PRM scores between baseline stage and control group (P0.05). During the follow-up period, at the end of 2 months in the study group, the SANS score, that is, the indexes of SAF,SVB,SISL,SVB,SPT, and SAD were decreased, and the total score of SANS was lower than that at the end of January. (2) PANSS score, that is, POS,NEG,GPS index was lower than that at the end of January, and total score decreased; (3) PRM score, that is, N, T _ 1, T _ 2 index was lower than that at the end of January, the difference was statistically significant (P0.05). There was no significant difference in SANS,PANSS and PRM scores between control group and control group at the end of January (P0.05). Conclusion: the negative symptoms of patients with schizophrenia can be relieved by high-frequency rTMS stimulation, and the effect is more obvious 2 months after treatment. The cognitive function of patients can be improved by high-frequency rTMS stimulation.
【學位授予單位】：南昌大學
【學位級別】：碩士
【學位授予年份】：2017
【分類號】：R749.3

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