【摘要】：目的:研究分析重復(fù)經(jīng)顱磁刺激(rTMS)治療精神分裂癥陰性癥狀的療效評估。方法:隨機(jī)選取本院精神科患有精神分裂癥患者66例,且均殘留明顯的陰性癥狀�；颊弑浑S機(jī)分為兩組,研究組使用高頻rTMS刺激治療,對照組使用rTMS刺激偽治療,兩組患者分別治療為期1個月,并進(jìn)行1個月隨訪,通過對PANSS、SANS、PRM指標(biāo)分值測試,對患者臨床癥狀進(jìn)行分析對比。其中運用的工具為:用于測量PANSS陽性與陰性癥狀量表、成人安全篩查表檢測患者是否可以進(jìn)行高頻rTMS刺激、測量SANS指標(biāo)的陰性癥狀量表(SANS)以及對心理、認(rèn)知功能進(jìn)行測試的劍橋自動化成套神經(jīng)心理測試等進(jìn)行臨床評估。對比分析兩組患者治療前后PANSS、SANS、PRM指標(biāo)的總分評分并對比兩組的療效。結(jié)果:治療期間,研究組患者1個月末:(1)SANS評分,即SAF、SVB、SISL、SVB、SPT、及SAD指標(biāo)較基線期均有所下降,且SANS總分降低;(2)PANSS評分,即POS、NEG、GPS指標(biāo)較基線期降低,且總分下降;(3)PRM評分,即N、T1、T2指標(biāo)較基線期較低,差異有統(tǒng)計學(xué)意義(P0.05)。對照組患者SANS、PANSS及PRM評分較基線期不明顯變化,差異無統(tǒng)計學(xué)意義(P0.05)。隨訪期間,研究組患者2個月末:SANS評分,即SAF、SVB、SISL、SVB、SPT、及SAD指標(biāo)較1月末均有所下降,且SANS總分降低;(2)PANSS評分,即POS、NEG、GPS指標(biāo)較1月末降低,且總分下降;(3)PRM評分,即N、T1、T2指標(biāo)較1月末較低,差異有統(tǒng)計學(xué)意義(P0.05)。對照組對照組患者SANS、PANSS及PRM評分較1月末不明顯變化,差異無統(tǒng)計學(xué)意義(P0.05)。結(jié)論:采用高頻rTMS刺激治療,精神分裂患者陰性癥狀可得到緩解,效果在治療后2個月后較為明顯,并且通過高頻rTMS刺激,可提高患者的認(rèn)知功能。
[Abstract]:Objective: to evaluate the efficacy of repetitive transcranial magnetic stimulation (rTMS) in the treatment of negative symptoms of schizophrenia. Methods: 66 patients with schizophrenia in our psychiatric department were randomly selected, all of whom had significant negative symptoms. The patients were randomly divided into two groups: the study group was treated with high frequency rTMS stimulation, and the control group was treated with rTMS stimulation false therapy. The patients in the two groups were treated for a period of 1 month and followed up for 1 month. The clinical symptoms of the patients were analyzed and compared. The tools used are: the PANSS positive and negative symptom scale, the adult safety screening table to detect whether patients can be stimulated with high frequency rTMS, the negative symptom scale (SANS) of SANS index, and the psychological control. Cambridge automated neuropsychological tests for cognitive function testing were used for clinical evaluation. The total score of PANSS,SANS,PRM before and after treatment was compared between the two groups and the curative effect was compared between the two groups. Results: at the end of one month after treatment, the patients in the study group were: (1) the SANS score, that is, the indexes of SAF,SVB,SISL,SVB,SPT, and SAD were lower than those in the baseline stage, and the total score of SANS was lower; (2) PANSS score, that is, POS,NEG,GPS index was lower than baseline stage, and total score decreased; (3) PRM score, that is, N, T _ 1, T _ 2 index was lower than baseline stage, the difference was statistically significant (P0.05). There was no significant difference in SANS,PANSS and PRM scores between baseline stage and control group (P0.05). During the follow-up period, at the end of 2 months in the study group, the SANS score, that is, the indexes of SAF,SVB,SISL,SVB,SPT, and SAD were decreased, and the total score of SANS was lower than that at the end of January. (2) PANSS score, that is, POS,NEG,GPS index was lower than that at the end of January, and total score decreased; (3) PRM score, that is, N, T _ 1, T _ 2 index was lower than that at the end of January, the difference was statistically significant (P0.05). There was no significant difference in SANS,PANSS and PRM scores between control group and control group at the end of January (P0.05). Conclusion: the negative symptoms of patients with schizophrenia can be relieved by high-frequency rTMS stimulation, and the effect is more obvious 2 months after treatment. The cognitive function of patients can be improved by high-frequency rTMS stimulation.
【學(xué)位授予單位】：南昌大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R749.3

【參考文獻(xiàn)】

相關(guān)期刊論文 前10條

1 黃婉立;沈芳;張江濤;邢葆平;;重復(fù)經(jīng)顱磁刺激對住院精神分裂癥患者吸煙數(shù)量的影響（英文）[J];上海精神醫(yī)學(xué);2016年06期

2 李哲;杜向東;張?zhí)m蘭;楊建功;楊力;殷銘;潘能榮;黃自勇;顧震;謝年秀;楊忠;;高頻重復(fù)經(jīng)顱磁刺激治療以陰性癥狀為主的慢性精神分裂癥對照研究[J];臨床心身疾病雜志;2016年05期

3 杜向東;殷銘;李哲;楊力;張?zhí)m蘭;潘能榮;黃自勇;顧震;楊建功;謝年秀;楊忠;;高頻重復(fù)經(jīng)顱磁刺激對慢性精神分裂癥患者認(rèn)知功能的影響[J];神經(jīng)疾病與精神衛(wèi)生;2016年04期

4 徐清;張玉琦;程灶火;;高頻rTMS對慢性精神分裂癥陰性癥狀的遠(yuǎn)期康復(fù)作用[J];中國康復(fù);2016年03期

5 鐘遠(yuǎn)惠;鄭偉;謝穗峰;何曉華;李宏斌;;重復(fù)經(jīng)顱磁刺激對首發(fā)精神分裂癥患者血清腦源性神經(jīng)營養(yǎng)因子的影響[J];神經(jīng)疾病與精神衛(wèi)生;2016年03期

6 張少霞;李一凡;鄭麗華;謝益潮;;高頻率10Hz下重復(fù)經(jīng)顱磁刺激對慢性精神分裂癥陰性癥狀的療效[J];中國當(dāng)代醫(yī)藥;2016年16期

7 白莉;甘景梨;梁學(xué)軍;段惠峰;高存友;;重復(fù)經(jīng)顱磁刺激對精神分裂癥患者彌散張量成像及陰性癥狀的影響[J];中國健康心理學(xué)雜志;2015年05期

8 段惠峰;甘景梨;連亞軍;史振娟;高存友;張毅;高延倫;;重復(fù)經(jīng)顱磁刺激對精神分裂癥患者血清腦源性神經(jīng)營養(yǎng)因子的影響[J];中華神經(jīng)醫(yī)學(xué)雜志;2014年10期

9 楊濤;田博;武春建;;精神分裂癥陰性癥狀發(fā)病機(jī)制及治療的研究進(jìn)展[J];神經(jīng)疾病與精神衛(wèi)生;2014年03期

10 甘景梨;程正祥;段惠峰;祝希泉;史振娟;高存友;梁學(xué)軍;趙蘭民;;θ短陣快速脈沖經(jīng)顱磁刺激治療精神分裂癥難治性陰性癥狀的隨機(jī)對照研究[J];中華精神科雜志;2014年03期

相關(guān)碩士學(xué)位論文 前7條

1 李哲;高頻重復(fù)經(jīng)顱磁刺激（rTMS）治療精神分裂癥陰性癥狀的療效隨訪研究[D];蘇州大學(xué);2015年

2 劉瑞凌;高頻重復(fù)經(jīng)顱磁刺激治療抑郁癥患者的臨床研究[D];安徽醫(yī)科大學(xué);2015年

3 朱佩;攻擊性精神分裂癥患者fMRI數(shù)據(jù)特征的統(tǒng)計學(xué)研究[D];湖南大學(xué);2014年

4 王琳;高頻重復(fù)經(jīng)顱磁刺激對正常青年人認(rèn)知控制能力的影響—一項ERP研究[D];河北醫(yī)科大學(xué);2013年

5 劉明;精神分裂癥認(rèn)知功能損害的特點及干預(yù)研究[D];山西醫(yī)科大學(xué);2011年

6 張詠梅;高低頻率重復(fù)經(jīng)顱磁刺激治療抑郁癥對照研究[D];南昌大學(xué);2010年

7 徐暉;精神分裂癥患者病恥感及其與服藥依從性關(guān)系的研究[D];中國協(xié)和醫(yī)科大學(xué);2008年

，

本文編號：2454471