發(fā)布時間：2018-12-08 10:48

【摘要】：目的研究阿爾茨海默病(Alzheimer’s disease,AD)進程中不同認知轉(zhuǎn)歸結(jié)局健康相關(guān)生命質(zhì)量(healthrelated quality of life,HRQOL)的主要影響因素。方法將阿爾茨海默病進程中的疾病狀態(tài)和生命質(zhì)量相結(jié)合,以認知正常老化為狀態(tài)1、輕度認知障礙為狀態(tài)2、中重度認知障礙為狀態(tài)3、阿爾茨海默病為狀態(tài)4,針對3次隨訪的縱向資料,引入廣義估計方程,研究AD進程中HRQOL隨疾病狀態(tài)轉(zhuǎn)移的影響因素。結(jié)果狀態(tài)1至狀態(tài)2 HRQOL有統(tǒng)計學(xué)意義的影響因素是婚姻、離休前職業(yè)、參加娛樂公益活動、吸煙、GDS;狀態(tài)2至狀態(tài)3 HRQOL影響因素是婚姻、夫妻關(guān)系、出生胎次、參加體育鍛煉、一級親屬癡呆、ADL、GDS;狀態(tài)3至狀態(tài)4 HRQOL影響因素是教育水平、退休后第二職業(yè)、做家務(wù)情況、參加體育鍛煉、喝茶、一級親屬癡呆、高血脂、GDS;狀態(tài)3至狀態(tài)2 HRQOL影響因素是教育水平、離休前職業(yè)、業(yè)余愛好、喝茶、吸煙、鋁制炊具使用、控制食量、腦部疾患、ADL、GDS。結(jié)論 AD進程中HRQOL隨狀態(tài)轉(zhuǎn)移的影響因素各有不同,應(yīng)該根據(jù)不同認知轉(zhuǎn)歸結(jié)局生命質(zhì)量各自的影響因素,制定疾病分階段衛(wèi)生政策,提高老年人生命質(zhì)量。
[Abstract]:Objective to study the main influencing factors of health-related quality of life (healthrelated quality of life,HRQOL) in patients with Alzheimer's disease (Alzheimer's disease,AD) with different cognitive outcomes. Methods the state of disease and quality of life in the course of Alzheimer's disease were combined. Cognitive normal aging was considered as state 1, mild cognitive impairment as state 2, moderate and severe cognitive impairment as state 3, and Alzheimer's disease as state 4. Based on the longitudinal data of three follow-up visits, the generalized estimation equation was introduced to study the influencing factors of HRQOL metastasis with disease state in the process of AD. Results from state 1 to state 2, HRQOL were significantly affected by marriage, pre-retirement occupation, participation in recreational activities, smoking, and GDS;. The influencing factors of state 2 to state 3 HRQOL are marriage, marital relationship, birth order, physical exercise, dementia of first-degree relatives, ADL,GDS;. The influencing factors of state 3 to 4 HRQOL are educational level, second occupation after retirement, housework, physical exercise, tea drinking, dementia of first-degree relatives, hyperlipidemia, GDS;. The influencing factors of state 3 to state 2 HRQOL are educational level, pre-retirement occupation, hobbies, tea, smoking, aluminum cooking utensils, food control, brain disorders, ADL,GDS.. Conclusion the influencing factors of HRQOL in the process of AD are different with the change of state. According to the influencing factors of the quality of life of different cognitive outcomes, the health policy of disease stages should be formulated to improve the quality of life of the elderly.
【作者單位】： 山西醫(yī)科大學(xué)衛(wèi)生統(tǒng)計學(xué)教研室;太原市中心醫(yī)院;
【基金】：國家自然科學(xué)基金(30972545) 山西省國際科技合作計劃項目(2012081047) 山西省留學(xué)回國人員科技活動擇優(yōu)項目 山西醫(yī)科大學(xué)科技創(chuàng)新項目
【分類號】：R749.16

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