發(fā)布時間：2018-11-18 20:55

【摘要】：目的探討重復經顱磁刺激對老年抑郁癥患者臨床癥狀及自殺意念的療效。方法將178例老年抑郁癥有自殺意念的患者隨機分為兩組,研究組80例,對照組98例,兩組均給予常規(guī)藥物治療,研究組在常規(guī)藥物治療的基礎上聯(lián)合重復經顱磁刺激治療,每周5次,2周為1個療程,治療4周。分別于治療前、治療2周、治療4周后采用漢密爾頓抑郁量表(HAMD)和自殺意念自評量表(SIOSS)對治療效果進行評分。治療2周后減分率≥20%為顯效,治療4周后減分率≥25%為有效。結果(1)兩組患者在年齡、性別、民族、職業(yè)、婚姻狀況、受教育程度等方面比較均無統(tǒng)計學差異(P0.05);(2)兩組患者治療前HAMD評分及SIOSS評分無統(tǒng)計學差異(P0.05),治療后兩組的評分均有不同程度的降低,但研究組更顯著(P0.05);(3)研究組在治療2周后顯效率明顯高于對照組,兩組比較有顯著的統(tǒng)計學意義(52.5%vs 28.6%;χ2=10.569,P0.01);研究組治療4周后的有效率明顯高于對照組,兩組比較有顯著的統(tǒng)計學意義(77.5%vs 53.1%;χ2=15.470,P0.05)。結論重復經顱磁刺激能縮短起效時間,改善老年抑郁癥患者的臨床癥狀,首先改善患者睡眠質量,隨治療時間的延長,認識障礙、軀體化癥狀、遲緩等狀況也明顯改善,并且能減輕老年抑郁癥患者的自殺意念,降低自殺風險。
[Abstract]:Objective to investigate the effect of repeated transcranial magnetic stimulation (TMS) on clinical symptoms and suicidal ideation in elderly patients with depression. Methods 178 elderly patients with suicidal ideation were randomly divided into two groups: study group (n = 80) and control group (n = 98). Five times a week, 2 weeks as a course of treatment for 4 weeks. Hamilton Depression scale (HAMD) and suicide Ideation scale (SIOSS) were used to evaluate the therapeutic effect before, 2 weeks and 4 weeks respectively. After 2 weeks treatment, the score reduction rate 鈮，

本文編號：2341196