【摘要】：目的：探討原絡(luò)通經(jīng)針?lè)ㄅ浜纤幬?多奈哌齊片)治療非癡呆血管性認(rèn)知障礙的臨床療效及其對(duì)事件相關(guān)電位P300的影響。 方法：將40例符合納入、排除標(biāo)準(zhǔn)的非癡呆血管性認(rèn)知障礙患者隨機(jī)分為治療組和對(duì)照組,每組20例。治療組采用原絡(luò)通經(jīng)針?lè)ㄅ浜纤幬?多奈哌齊片)治療,對(duì)照組采用單純藥物(多奈哌齊片)治療。兩組療效均為6周。采用肌電-誘發(fā)電位儀聽覺(jué)odball程序由同一操作者對(duì)患者治療前后各檢查1次；由專業(yè)人員于治療前后對(duì)患者進(jìn)行簡(jiǎn)易精神狀態(tài)檢查量表(MMSE)評(píng)分和蒙特利爾認(rèn)知評(píng)估量表(MoCA)評(píng)分評(píng)定,并進(jìn)行治療前后MMSE和MoCA評(píng)分及事件相關(guān)電位P300的N2和P3潛伏期、波幅變化比較。 結(jié)果：治療組總有效率為85.00%,對(duì)照組總有效率為65.00%,兩組總有效率比較差異具有統(tǒng)計(jì)學(xué)意義(p0.05)。兩組治療后簡(jiǎn)易精神狀態(tài)檢查量表(MMSE)評(píng)分和蒙特利爾認(rèn)知評(píng)估量表(MoCA)評(píng)分均較同組治療前有明顯提高(p0.01,p0.05)；治療組治療后簡(jiǎn)易精神狀態(tài)檢查量表(MMSE)評(píng)分和蒙特利爾認(rèn)知評(píng)估量表(MoCA)評(píng)分均優(yōu)于對(duì)照組,兩組比較差異具有統(tǒng)計(jì)學(xué)意義(p0.05)。兩組患者治療后N2和P3潛伏期與治療前比較均明顯縮短組內(nèi)治療前后潛伏期比較,差異均有統(tǒng)計(jì)學(xué)意義(p0.01,p0.05)；兩組患者治療后N2和P3波幅與治療前比較均明顯增高,組內(nèi)治療前后波幅比較,差異均有統(tǒng)計(jì)學(xué)意義(p0.01,p0.05)。治療后,治療組N2和P3潛伏期縮短及波幅增高均顯著優(yōu)于對(duì)照組,兩組比較差異均有統(tǒng)計(jì)學(xué)意義(p0.05)。 結(jié)論：原絡(luò)通經(jīng)針?lè)?lián)合藥物(多奈哌齊片)可用于非癡呆血管性認(rèn)知障礙的治療,能夠改善患者的認(rèn)知功能,是非癡呆血管性認(rèn)知障礙的有效干預(yù)方法。
[Abstract]:Objective: to investigate the clinical effect of Fuluo Tongjing acupuncture combined with medicine (Donepezil tablet) in the treatment of non-dementia vascular cognitive impairment and its effect on event-related potential (P300). Methods: 40 patients with non-dementia vascular cognitive impairment were randomly divided into treatment group and control group with 20 cases in each group. The treatment group was treated with original collaterals and meridian acupuncture combined with medicine (Donepezil tablet), while the control group was treated with simple drug (Donepezil tablet). The curative effect was 6 weeks in both groups. The electromyoelectric evoked potentiometer auditory odball program was used to examine the patients before and after treatment. Before and after treatment, the patients were assessed with the mini-mental state examination scale (MMSE) and the Montreal Cognitive Assessment scale (MoCA). The MMSE and MoCA scores and the N2 and P3 latencies of event-related potentials (P300) were evaluated before and after treatment. Comparison of amplitude variations. Results: the total effective rate was 85.00 in the treatment group and 65.00 in the control group. The difference of the total effective rate between the two groups was statistically significant (p0.05). The scores of (MMSE) and (MoCA) were significantly higher in the two groups after treatment than those before treatment (p0.01 / p0.05). The (MMSE) score of mini-mental state examination scale and the (MoCA) score of Montreal Cognitive Assessment scale in the treatment group were better than those in the control group after treatment. The difference between the two groups was statistically significant (p0.05). The latencies of N2 and P3 in the two groups were significantly shortened after treatment compared with those before and after treatment, and the differences were statistically significant (p0.01 / p0.05). The amplitude of N2 and P3 was significantly increased after treatment in both groups, and the difference was statistically significant before and after treatment (p0.01 / p0.05). After treatment, the latency and amplitude of N2 and P3 in the treatment group were significantly shorter than those in the control group, and the difference between the two groups was statistically significant (p0.05). Conclusion: Yuanluotong meridian acupuncture combined with medicine (Donepezil tablet) can be used in the treatment of non-dementia vascular cognitive disorders, can improve the cognitive function of patients, non-dementia vascular cognitive impairment of effective intervention.
【學(xué)位授予單位】：黑龍江中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2012
【分類號(hào)】：R749.1

【參考文獻(xiàn)】

相關(guān)期刊論文 前10條

1 馮炯;臧敏;;六味地黃丸治療輕中度血管性認(rèn)知障礙的臨床研究[J];中醫(yī)藥臨床雜志;2010年02期

2 郁曉群;張楠;夏煜;;通心絡(luò)治療多發(fā)性腦腔隙性梗死伴血管性認(rèn)知功能障礙的臨床觀察[J];北方藥學(xué);2011年05期

3 劉智艷;劉娟;曲紅巖;;電針對(duì)老年性癡呆大鼠認(rèn)知障礙的影響[J];中華中醫(yī)藥雜志;2009年06期

4 黃凡;劉悅;周飛雄;姚國(guó)新;賀清濤;;針刺對(duì)腦梗死后血管性認(rèn)知障礙的影響[J];廣東醫(yī)學(xué);2008年11期

5 趙厚睿;王平;;《黃帝內(nèi)經(jīng)》健忘病機(jī)探討[J];光明中醫(yī);2011年12期

6 王本孝;黃自麗;許平;;血管性認(rèn)知功能障礙的臨床研究進(jìn)展[J];神經(jīng)損傷與功能重建;2009年04期

7 畢莉珠;何迎春;張如富;;輕度認(rèn)知功能障礙的研究進(jìn)展[J];國(guó)際老年醫(yī)學(xué)雜志;2010年03期

8 王相斌;宋福聰;郭鵬;張保剛;馮文霞;;卒中后認(rèn)知功能障礙與神經(jīng)元特異性烯醇化酶相關(guān)性研究[J];河北醫(yī)藥;2010年11期

9 白鈺;陳永燦;;金元醫(yī)家論治健忘特色擷菁[J];湖北中醫(yī)雜志;2009年12期

10 肖芝;朱宏;董克禮;;補(bǔ)腎活血法治療輕度認(rèn)知障礙20例臨床觀察[J];湖南中醫(yī)雜志;2011年04期

，

本文編號(hào)：2323937