社會(huì)認(rèn)知交互訓(xùn)練對(duì)雙相情感障礙緩解期患者的影響
發(fā)布時(shí)間：2018-11-02 11:36
【摘要】：目的:觀察社會(huì)認(rèn)知交互訓(xùn)練(Social Cognition and Interaction Training,SCIT)對(duì)雙相障礙緩解期患者臨床癥狀及社會(huì)功能和認(rèn)知功能的影響,為臨床預(yù)防與干預(yù)提供依據(jù)。通過對(duì)社會(huì)認(rèn)知交互訓(xùn)練(SCIT)和健康教育兩種方式培訓(xùn)后,兩組成員間在HAMD-17、YMRS上有無差異,探討SCIT對(duì)于雙相情感障礙患者癥狀的控制的幫助大小。通過對(duì)SCIT組和對(duì)照組在基線和8周末的認(rèn)知功能及FAST變化的分析,探討SCIT培訓(xùn)對(duì)雙相情感障礙患者認(rèn)知功能、整體功能的影響。通過詳細(xì)分析FAST各個(gè)維度在培訓(xùn)前后的改變,探討SCIT對(duì)于雙相情感障礙患者在哪些維度上作用較為明顯。本研究引進(jìn)和調(diào)整后的SCIT培訓(xùn)方法,拓展了對(duì)于雙相情感障礙患者的輔助治療,希望本研究對(duì)于SCIT在中國雙相情感障礙緩解期患者的輔助治療上提供依據(jù)和數(shù)據(jù)支撐,并為有關(guān)雙相情感障礙患者的后續(xù)研究及延伸到其他疾病種類提供理論參考。方法:采用前瞻性、隨機(jī)分組、8周干預(yù)的方法,依據(jù)精神障礙統(tǒng)計(jì)與診斷手冊(cè)第5版(DSM-5)的中雙相障礙緩解期的診斷標(biāo)準(zhǔn)對(duì)符合入組的80名緩解期患者,隨機(jī)方法分成2組,即SCIT組和對(duì)照組(健康教育組),兩組各40名,其中SCIT組脫落5例,對(duì)照組脫落1例。采用漢密爾頓抑郁量表(HAMD-17)、楊氏躁狂量表(YMRS)、功能檢測簡版(FAST)、認(rèn)知功能成套測驗(yàn)中文版(MCCB)等測驗(yàn)分別在基線和治療8周給予評(píng)估,統(tǒng)計(jì)上采用IBM公司的SPSS軟件23.0版本進(jìn)行數(shù)據(jù)整理分析。計(jì)數(shù)資料選用χ2檢驗(yàn)分析,采用百分比形式表示;若計(jì)量資料符合正態(tài)分布,則選用獨(dú)立t檢驗(yàn)、配對(duì)t檢驗(yàn)進(jìn)行分析,采用均數(shù)±標(biāo)準(zhǔn)差的形式表示;數(shù)據(jù)間的關(guān)聯(lián)性,選用皮爾遜相關(guān)性分析,采用關(guān)聯(lián)系數(shù)形式表示。以p0.05為統(tǒng)計(jì)具有顯著性意義。結(jié)果:1.入組的兩組被試者在人口資料方面,包括性別、年齡、婚姻狀況、吸煙史、飲酒史、職業(yè)狀況、教育年限,以及總病程年限、發(fā)病次數(shù)、家族史等一般社會(huì)和人口學(xué)資料差異未發(fā)現(xiàn)統(tǒng)計(jì)學(xué)意義(p㧐0.05)。2.兩組被試者的HAMD-17和YMRS評(píng)分在入組時(shí)差異不具有統(tǒng)計(jì)學(xué)意。治療8周末,SCIT組與對(duì)照組在HAMD-17、YMRS得分,SCIT組的減分更加明顯,兩者差異具有統(tǒng)計(jì)學(xué)意義(p0.05)。3.SCIT組和對(duì)照組在培訓(xùn)結(jié)束后,SCIT組在功能檢測簡版(FAST)得分上具有較明顯的減分,兩者差異具有統(tǒng)計(jì)學(xué)意義(p0.05)。4.SCIT組和對(duì)照組在培訓(xùn)結(jié)束后,認(rèn)知功能方面的評(píng)估得分發(fā)現(xiàn),SCIT組被試者在記憶力、邏輯推理能力、執(zhí)行功能方面的功能得分均高于對(duì)照組,兩組間差異具有統(tǒng)計(jì)學(xué)意義(p0.05)。結(jié)論:SCIT可能在雙相障礙緩解期患者的臨床癥狀的緩解、總體社會(huì)功能和認(rèn)知功能相關(guān)改善起到相應(yīng)作用,具有臨床干預(yù)前景。
[Abstract]:Objective: to observe the effect of social cognitive interaction training (Social Cognition and Interaction Training,SCIT) on clinical symptoms, social function and cognitive function in patients with bipolar disorder in remission period, and to provide evidence for clinical prevention and intervention. After (SCIT) and health education were trained, there was no difference in HAMD-17,YMRS between the two groups, and the help of SCIT in controlling the symptoms of bipolar affective disorder patients was discussed. The effects of SCIT training on cognitive function and overall function of patients with bipolar affective disorder (bipolar affective disorder) were studied by analyzing the changes of cognitive function and FAST in SCIT group and control group at baseline and 8 weeks. Through the detailed analysis of the changes of each dimension of FAST before and after training, the effects of SCIT on the dimensions of bipolar affective disorder were discussed. This study introduces and adjusts the SCIT training method to expand the adjuvant treatment for bipolar affective disorder patients. It is hoped that this study can provide the basis and data support for the adjuvant treatment of bipolar affective disorder patients in China. It also provides a theoretical reference for the follow-up study of bipolar affective disorder and its extension to other diseases. Methods: according to the diagnostic criteria of the middle bipolar disorder (DSM-5) in the fifth edition of the Manual of Statistics and diagnosis of Mental Disorder (DSM-5), 80 patients were enrolled in the study according to the prospective, randomized and 8-week intervention. Methods randomly divided into two groups, SCIT group and control group (health education group), the two groups of 40 cases, SCIT group lost 5 cases, control group 1 case. Hamilton Depression scale (HAMD-17) and Young's mania scale (YMRS),) were used to test the cognitive function of (FAST),. The Chinese version of (MCCB) was evaluated at baseline and 8 weeks after treatment. Statistical data analysis using IBM SPSS software version 23. 0. The counting data were analyzed by 蠂 ~ 2 test, expressed in percentage form, if the measured data were normal distribution, the independent t test was used to analyze, and the mean 鹵standard deviation was used to analyze the counting data. Pearson correlation analysis is used to express the correlation between data. P0.05 was statistically significant. The result is 1: 1. In terms of demographic data, the two groups included sex, age, marital status, smoking history, drinking history, professional status, education, total course of disease, number of cases. The difference of general social and demographic data, such as family history, was not statistically significant (p0.05). There was no significant difference in HAMD-17 and YMRS scores between the two groups when they entered the group. At the end of the 8th week of treatment, the scores of HAMD-17,YMRS in SCIT group and control group were significantly higher than those in SCIT group (p0.05). After training, the difference between 3.SCIT group and control group was significant (p0.05). The scores of (FAST) in the SCIT group were significantly lower than those in the control group (p0.05). After training, the scores of cognitive function in the 4.SCIT group and the control group were found to be significantly lower than those in the control group. The scores of memory, logical reasoning and executive function in SCIT group were significantly higher than those in control group (p0.05). Conclusion: SCIT may play a corresponding role in the relief of clinical symptoms, overall social function and cognitive function in patients with bipolar disorder in remission stage, and has the prospect of clinical intervention.
【學(xué)位授予單位】：天津醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R749.4
本文編號(hào)：2305896
[Abstract]:Objective: to observe the effect of social cognitive interaction training (Social Cognition and Interaction Training,SCIT) on clinical symptoms, social function and cognitive function in patients with bipolar disorder in remission period, and to provide evidence for clinical prevention and intervention. After (SCIT) and health education were trained, there was no difference in HAMD-17,YMRS between the two groups, and the help of SCIT in controlling the symptoms of bipolar affective disorder patients was discussed. The effects of SCIT training on cognitive function and overall function of patients with bipolar affective disorder (bipolar affective disorder) were studied by analyzing the changes of cognitive function and FAST in SCIT group and control group at baseline and 8 weeks. Through the detailed analysis of the changes of each dimension of FAST before and after training, the effects of SCIT on the dimensions of bipolar affective disorder were discussed. This study introduces and adjusts the SCIT training method to expand the adjuvant treatment for bipolar affective disorder patients. It is hoped that this study can provide the basis and data support for the adjuvant treatment of bipolar affective disorder patients in China. It also provides a theoretical reference for the follow-up study of bipolar affective disorder and its extension to other diseases. Methods: according to the diagnostic criteria of the middle bipolar disorder (DSM-5) in the fifth edition of the Manual of Statistics and diagnosis of Mental Disorder (DSM-5), 80 patients were enrolled in the study according to the prospective, randomized and 8-week intervention. Methods randomly divided into two groups, SCIT group and control group (health education group), the two groups of 40 cases, SCIT group lost 5 cases, control group 1 case. Hamilton Depression scale (HAMD-17) and Young's mania scale (YMRS),) were used to test the cognitive function of (FAST),. The Chinese version of (MCCB) was evaluated at baseline and 8 weeks after treatment. Statistical data analysis using IBM SPSS software version 23. 0. The counting data were analyzed by 蠂 ~ 2 test, expressed in percentage form, if the measured data were normal distribution, the independent t test was used to analyze, and the mean 鹵standard deviation was used to analyze the counting data. Pearson correlation analysis is used to express the correlation between data. P0.05 was statistically significant. The result is 1: 1. In terms of demographic data, the two groups included sex, age, marital status, smoking history, drinking history, professional status, education, total course of disease, number of cases. The difference of general social and demographic data, such as family history, was not statistically significant (p0.05). There was no significant difference in HAMD-17 and YMRS scores between the two groups when they entered the group. At the end of the 8th week of treatment, the scores of HAMD-17,YMRS in SCIT group and control group were significantly higher than those in SCIT group (p0.05). After training, the difference between 3.SCIT group and control group was significant (p0.05). The scores of (FAST) in the SCIT group were significantly lower than those in the control group (p0.05). After training, the scores of cognitive function in the 4.SCIT group and the control group were found to be significantly lower than those in the control group. The scores of memory, logical reasoning and executive function in SCIT group were significantly higher than those in control group (p0.05). Conclusion: SCIT may play a corresponding role in the relief of clinical symptoms, overall social function and cognitive function in patients with bipolar disorder in remission stage, and has the prospect of clinical intervention.
【學(xué)位授予單位】：天津醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R749.4
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