【摘要】：目的探討腦源性神經(jīng)營養(yǎng)因子(BDNF)基因功能性多態(tài)(rs6265)與散發(fā)性阿爾茨海默病(SAD)發(fā)病的相關(guān)性。方法選取58例SAD患者(SAD組)與52例健康老年人(對照組),用聚合酶鏈反應(yīng)-限制性片段長度多態(tài)性技術(shù),對BDNF基因rs6265進(jìn)行檢測,同時利用酶聯(lián)免疫吸附技術(shù)對兩組患者的血清BDNF水平進(jìn)行檢測。結(jié)果在65歲的人群中,等位基因(χ2=6.059 5,P=0.013)及基因型(χ2=6.082 6,P=0.0478)在兩組人群中的分布有顯著差異,并且SAD組AA基因型患者的血清BDNF水平最低〔(14.32±4.21)ng/ml,F=7.254 5,P=0.001 6〕。結(jié)論BDNF基因功能性多態(tài)rs6265與SAD發(fā)病相關(guān),并且影響其血清BDNF的表達(dá)。
[Abstract]:Objective to investigate the relationship between functional polymorphism (rs6265) of brain-derived neurotrophic factor (BDNF) gene and sporadic Alzheimer's disease (SAD). Methods BDNF gene rs6265 was detected by polymerase chain reaction-restriction fragment length polymorphism (PCR) in 58 patients with SAD (SAD group) and 52 healthy elderly (control group). At the same time, the serum BDNF level of the two groups was detected by enzyme linked immunosorbent assay (Elisa). Results there was a significant difference in the distribution of alleles (蠂 ~ 2 + 6.059 5) and genotype (蠂 ~ 2 + 6.082 ~ (6) P ~ (0.0478) between the two groups, and the lowest level of serum BDNF in patients with AA genotype in SAD group (14.32 鹵4.21) ng/ml,F=7.254 5P0.001 6). Conclusion functional polymorphic rs6265 of BDNF gene is associated with the pathogenesis of SAD and affects the expression of BDNF in serum.
【作者單位】： 廣西醫(yī)科大學(xué)第一附屬醫(yī)院神經(jīng)內(nèi)科;南寧殘疾兒童康復(fù)中心;
【基金】：廣西科學(xué)青年基金資助項目(桂科青0991036)
【分類號】：R749.16

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