發(fā)布時(shí)間：2018-09-18 18:21

【摘要】：目的探討APOEε4等位基因與尿AD7c-NTP聯(lián)合檢測(cè)在阿爾茲海默病(AD)早期診斷預(yù)防中的價(jià)值。方法根據(jù)中國(guó)精神障礙分類與診斷標(biāo)準(zhǔn)第三版(CCMD-3)有關(guān)精神分裂癥及輕度阿爾茲海默病的診斷標(biāo)準(zhǔn),選取76例臨床診斷疑似AD患者(PAD組),另選90例健康者作為對(duì)照組。對(duì)比兩組APOEε4等位基因頻率和尿AD7c-NTP含量對(duì)AD的診斷價(jià)值。結(jié)果 (1)APOEε4等位基因表達(dá)頻率在PAD組顯著高于對(duì)照組(P≤0.05);(2)尿AD7c-NTP在PAD組中的含量較對(duì)照組顯著升高(P≤0.01);(3)對(duì)APOEε4、AD7c-NTP及二者聯(lián)合檢測(cè)進(jìn)行比較發(fā)現(xiàn),APOEε4對(duì)AD診斷的靈敏度、特異度、陽(yáng)性預(yù)測(cè)值、陰性預(yù)測(cè)值、約登指數(shù)分別為:44.64%、88.33%、78.13%、63.10%、0.33;尿AD7c-NTP診斷的靈敏度、特異度、陽(yáng)性預(yù)測(cè)值、陰性預(yù)測(cè)值、約登指數(shù)分別為:78.57%、83.33%、81.48、80.65%、0.62;APOEε4與AD7c-NTP聯(lián)合檢測(cè)的診斷靈敏度、特異度、陽(yáng)性預(yù)測(cè)值、陰性預(yù)測(cè)值、約登指數(shù)分別為:91.18%、91.55%、83.78%、95.58%、0.82。結(jié)論 APOEε4等位基因與尿AD7c-NTP聯(lián)合檢測(cè)是監(jiān)測(cè)及診斷AD早期病變的較好指標(biāo),提升二者單獨(dú)應(yīng)用時(shí)的預(yù)測(cè)價(jià)值,宜作為AD易發(fā)人群鑒別和早期診斷的生物標(biāo)記物。
[Abstract]:Objective to investigate the value of combined detection of APOE 蔚 4 allele and urinary AD7c-NTP in early diagnosis and prevention of Alzheimer's disease (AD). Methods according to the diagnostic criteria of schizophrenia and mild Alzheimer's disease (CCMD-3), 76 suspected AD patients (PAD group) and 90 healthy persons (control group) were selected. The diagnostic value of APOE 蔚 4 allele frequency and urinary AD7c-NTP content in AD was compared between the two groups. Results (1) the frequency of APOE 蔚 4 allele expression in the PAD group was significantly higher than that in the control group (P 鈮，

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