發(fā)布時(shí)間：2018-07-21 11:02

【摘要】：阿爾采末病(AD)是一種中樞神經(jīng)系統(tǒng)退行性疾病,為最常見的癡呆類型。磷酸二酯酶包括一組水解細(xì)胞內(nèi)第二信使環(huán)磷酸腺苷和(或)環(huán)磷酸鳥苷的酶,已證實(shí)磷酸二酯酶抑制劑(PDE-Is)對(duì)AD動(dòng)物模型有積極的作用,如PDE4-I咯利普蘭、PDE5-I西地那非。本文對(duì)PDE-Is改善AD認(rèn)知功能及其作用機(jī)制作一綜述,旨在為后續(xù)研發(fā)新的PDE-Is用于AD的治療提供思路。
[Abstract]:Alzheimer's disease (AD) is a neurodegenerative disease of the central nervous system and is the most common type of dementia. Phosphodiesterase includes a group of enzymes that hydrolyze the second messenger adenosine monophosphate and / or cyclic guanosine monophosphate. It has been shown that phosphodiesterase inhibitors (PDE-Is) play a positive role in AD animal models, such as PDE4-I and PDE 5-I sildenafil. This article reviews the improvement of cognitive function and its mechanism in AD by PDE-Is in order to provide ideas for the development of new PDE-Is for AD treatment.
【作者單位】： 遵義醫(yī)學(xué)院藥理學(xué)教研室暨基礎(chǔ)藥理省部共建教育部重點(diǎn)實(shí)驗(yàn)室;
【基金】：教育部“長(zhǎng)江學(xué)者和創(chuàng)新團(tuán)隊(duì)發(fā)展計(jì)劃”創(chuàng)新團(tuán)隊(duì)(IRT1197) 貴州省科技廳優(yōu)秀青年科技人才資金(黔科合人字[2013]26)
【分類號(hào)】：R749.16

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