本文選題：潛變量增長曲線模型 + 阿爾茨海默病��； 參考：《中國衛(wèi)生統(tǒng)計》2014年01期

【摘要】：目的將阿爾茨海默病(Alzheimer's disease,AD)進程中的疾病狀態(tài)和生命質(zhì)量相結(jié)合,探討阿爾茨海默病健康相關(guān)生命質(zhì)量隨疾病狀態(tài)轉(zhuǎn)移的動態(tài)變化規(guī)律。方法針對3次隨訪的縱向資料,以認知正常老化為狀態(tài)1、輕度認知損害為狀態(tài)2、中重度認知損害為狀態(tài)3、阿爾茨海默病為狀態(tài)4,采用潛變量增長曲線模型,研究AD進程中健康相關(guān)生命質(zhì)量隨狀態(tài)轉(zhuǎn)移的動態(tài)變化規(guī)律。結(jié)果總的來說,初始狀態(tài)平均生命質(zhì)量為29.9,處于一般水平,并且存在顯著的個體差異;在隨訪期內(nèi),生命質(zhì)量有先升后降的趨勢,但變化速度卻不存在顯著的個體間差異,而且初始時生命質(zhì)量的高低與后來的變化速度之間相關(guān)不顯著。各個狀態(tài)轉(zhuǎn)移組初始狀態(tài)生命質(zhì)量存在著顯著的差異,狀態(tài)2→狀態(tài)3和狀態(tài)3→狀態(tài)4這兩個轉(zhuǎn)移組生命質(zhì)量有明顯的先升后降趨勢,而且前者升高要較后者明顯,生命質(zhì)量的發(fā)展速度存在顯著的個體間差異。狀態(tài)1→狀態(tài)2和狀態(tài)3→狀態(tài)2這兩個轉(zhuǎn)移組均未達到顯著水平。結(jié)論應根據(jù)AD進程中不同認知轉(zhuǎn)歸結(jié)局各自的發(fā)展變化,開展疾病分階段重點防治。潛變量增長模型在縱向研究中考慮到數(shù)據(jù)個體間差異,在應用中顯示出其特有的優(yōu)勢。
[Abstract]:Objective to study the dynamic changes of health-related quality of life (QOL) associated with Alzheimer's disease (AD) by combining disease status and quality of life (QOL) in Alzheimer's disease (AD). Methods according to the longitudinal data of 3 follow-up, cognitive normal aging as state 1, mild cognitive impairment as state 2, moderate and severe cognitive impairment as state 3, Alzheimer's disease as state 4, and latent variable growth curve model were used. To study the dynamic changes of health-related quality of life with state transition in AD process. Results in general, the average quality of life in the initial state was 29.9, which was at the average level, and there were significant individual differences. During the follow-up period, the quality of life increased first and then decreased, but there was no significant difference in the rate of change between individuals. Moreover, there was no significant correlation between the quality of life at the beginning and the rate of change later. There were significant differences in the initial state quality of life between each state transfer group. The quality of life of the two transfer groups, state 2 and state 3, increased first and then decreased, and the former increased more obviously than the latter. There are significant individual differences in the rate of development of quality of life. Neither state 1 nor state 3 were significant. Conclusion according to the development and change of different cognitive outcome in AD process, the prevention and treatment of disease should be carried out in stages. The latent variable growth model takes into account the differences between individuals in the longitudinal research and shows its unique advantages in application.
【作者單位】： 山西醫(yī)科大學數(shù)學教研室;山西醫(yī)科大學衛(wèi)生統(tǒng)計學教研室;
【基金】：國家自然科學基金(81373106) 山西省國際科技合作計劃項目(2012081047) 山西省留學回國人員科技活動擇優(yōu)項目
【分類號】：R749.16

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