本文選題：灼口綜合征 + 心理健康�。� 參考：《中南大學(xué)》2012年碩士論文

【摘要】：研究目的： (1)探討灼口綜合征(Burning Mouth Syndrome, BMS)患者的心理健康狀況,及各因素之間的相關(guān)關(guān)系； (2)探討B(tài)MS患者靜息態(tài)默認(rèn)網(wǎng)絡(luò)(default mode network, DMN)的異常改變,從而尋找BMS疾病特異性的生物學(xué)標(biāo)記。 研究方法： (1)收集60例BMS患者和60例按性別、年齡和教育程度相匹配的健康對照者,采用抑郁自評量表(Self-rating Depression Scale,SDS)、焦慮自評量表(Self-rating Anxiety Scale, SAS)、醫(yī)學(xué)應(yīng)對方式量表(Medical Coping Model Questionnaire, MCMQ)和艾森克人格問卷簡式量表(Eysenck Personality Questionnaire-Revised, Short Scale for Chinese, EPQRSC)對BMS患者和對照組進(jìn)行評定和統(tǒng)計分析。 (2)對15例BMS患者和15例年齡、性別、文化程度相匹配的健康對照者進(jìn)行1.5T靜息態(tài)功能磁共振掃描,獲得13例BMS患者和14例正常對照的有效數(shù)據(jù)。對數(shù)據(jù)進(jìn)行處理后,檢測患者組與對照組靜息態(tài)DMN有顯著性差異的腦區(qū)。 結(jié)果： (1)BMS患者的抑郁焦慮癥狀與其應(yīng)對方式和人格之間存在顯著相關(guān)。具體表現(xiàn)為：患者組抑郁、焦慮情緒明顯高于對照組；“回避”和“屈服”應(yīng)對方式與抑郁情緒呈正相關(guān)(r回避-抑郁=0.350,r屈服-抑郁=0.684)；精神質(zhì)、神經(jīng)質(zhì)人格與抑郁呈正相關(guān)(r精神質(zhì)-抑郁=0.634,r神經(jīng)質(zhì)-抑郁=0.580),與焦慮情緒也呈正相關(guān)(r精神質(zhì)-焦慮=0.550,r神經(jīng)質(zhì)-焦慮=0.595)。 (2)BMS患者靜息態(tài)DMN存在異常。具體表現(xiàn)為：DMN的前部如內(nèi)側(cè)前額葉、前扣帶回功能連接升高,而DMN后部楔前葉、角回功能連接降低(p0.05, t3, False Discovery Rate校正)。 結(jié)論： (1)BMS患者并發(fā)較高程度的抑郁、焦慮癥狀,同時不同人格類型和應(yīng)對方式對其焦慮、抑郁有較大影響。因此BMS病人應(yīng)根據(jù)其心理特點加強心理健康治療。 (2)BMS患者大腦靜息態(tài)DMN活動異常,特別是內(nèi)側(cè)前額葉、前扣帶回、楔前葉、角回是主要異常部位。該研究提示靜息態(tài)DMN的異�？赡苁荁MS的神經(jīng)病理機制之一。
[Abstract]:Objectives of the study: 1) to investigate the mental health status of Burning Mouth Syndrome, BMS) patients with Burning syndrome and the correlation between the factors. (2) to explore the abnormal changes of default mode network, DMN) in resting default network in patients with BMS, and to search for the specific biological markers of BMS disease. Research methods: We collected 60 patients with BMS and 60 healthy controls matched by sex, age and education. Self-rating Depression scale, Self-rating Anxiety scale, Medical coping style scale and Eysenck Personality Questionnaire-Revised, Short Scale for Chinese, EPQRSC) were used to evaluate and analyze BMS patients and controls. (2) Fifteen patients with BMS and 15 healthy controls with matched age, sex and education degree were scanned with 1.5T resting functional magnetic resonance imaging (fMRI). The effective data of 13 BMS patients and 14 normal controls were obtained. After the data were processed, the brain regions with significant difference in resting DMN were detected between the patient group and the control group. Results: There was a significant correlation between depression and anxiety symptoms and coping style and personality in BMS patients. The specific manifestations were as follows: depression and anxiety were significantly higher in the patients group than in the control group, the coping styles of "avoidance" and "yield" were positively correlated with the depression mood, and the coping styles were positively correlated with the depression mood. There was a positive correlation between neuroticism and depression, and a positive correlation between neuroticism and anxiety. There were abnormal resting DMN in patients with BMS. The functional junctions of anterior cingulate gyrus increased in the anterior part of DMN, while the functional junctions of angular gyrus decreased p0.05, T3, False Discovery Rate correction in the posterior cuneate lobe of DMN. Conclusion: BMS patients complicated with high degree of depression, anxiety symptoms, at the same time different personality types and coping styles have a greater impact on their anxiety and depression. Therefore, BMS patients should strengthen mental health treatment according to their psychological characteristics. DMN activity was abnormal in the rest state of brain, especially in medial prefrontal lobe, anterior cingulate gyrus, precuneiform lobe and angular gyrus. This study suggests that the abnormality of resting DMN may be one of the neuropathological mechanisms of BMS.
【學(xué)位授予單位】：中南大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2012
【分類號】：R749.2

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本文編號：1966936