本文選題：鹽酸美金剛 + 奧氮平��； 參考：《中國臨床藥理學(xué)雜志》2017年12期

【摘要】：目的觀察鹽酸美金剛聯(lián)合奧氮平治療阿爾茨海默病(AD)伴精神行為癥狀(BPSD)的臨床療效及安全性。方法將176例阿爾茨海默病患者隨機分為對照組89例和試驗組87例。對照組予以口服鹽酸美金剛,第1周每日5 mg,第2周每日10 mg,第3周每日15 mg,從第4周開始每日20 mg維持治療;試驗組在對照組鹽酸美金剛治療基礎(chǔ)上,予以加用奧氮平,每日2.5 mg,每晚口服,最大劑量每日10 mg;2組患者一個療程為2周,共治療6個療程。比較2組患者的臨床療效、日常生活能力量表(ADL)、神經(jīng)精神癥狀問卷(NPI-1,NPI-2)評分,以及藥物不良反應(yīng)發(fā)生率。結(jié)果治療后,試驗組和對照組的總有效率分別為90.70%(78/86例)和75.29%(64/85例),差異有統(tǒng)計學(xué)意義(P0.01)。試驗組和治療前及治療第2,4,8,12周NPI-1評分分別為(25.18±4.17),(23.02±3.98),(20.51±3.65),(17.85±3.08),(16.56±2.95)分;NPI-2評分分別為(46.86±4.65),(45.78±4.62),(43.53±4.24),(40.53±4.31),(38.91±4.27)分;ADL評分分別為(44.34±4.59),(44.25±4.53),(42.85±4.01),(40.30±3.98),(39.21±3.48)分。對照組NPI-1評分分別為(25.27±4.23),(24.67±4.12),(23.68±3.98),(21.36±3.57),(19.92±3.24)分;NPI-2評分分別為和(46.56±4.72),(46.31±4.51),(45.82±4.42),(43.21±4.37),(42.74±4.33)分;ADL評分分別為(43.62±4.61),(43.36±4.49),(43.08±4.25),(42.18±4.31),(41.27±4.29)分。第2,4,8周,試驗組與對照組的NPI-1,NPI-2,ADL差異均有統(tǒng)計學(xué)意義(P0.01)。試驗組的藥物不良反應(yīng)主要有嗜睡,體重增加,口干和便秘,對照組的藥物不良反應(yīng)主要有頭暈,失眠,頭痛和惡心。試驗組和對照組的藥物不良反應(yīng)發(fā)生率分別為8.14%(7/86例)和7.06%(6/85例),差異無統(tǒng)計學(xué)意義(P0.05)。結(jié)論鹽酸美金剛聯(lián)合奧氮平治療阿爾茨海默病伴精神行為癥狀的療效優(yōu)于單用鹽酸美金剛,且不增加藥物不良反應(yīng)的發(fā)生率。
[Abstract]:Objective to observe the clinical efficacy and safety of methadronium hydrochloride combined with olanzapine in the treatment of Alzheimer's disease (AD) with psychobehavioral symptoms (BPSD). Methods 176 patients with Alzheimer's disease were randomly divided into control group (89 cases) and trial group (87 cases). The control group received oral methadine hydrochloride, 5 mg per day in the first week, 10 mg daily in the second week, and 15 mg daily in the third week, starting from the fourth week, and the experimental group was given olanzapine plus olanzapine on the basis of the treatment of the control group. Two and a half mg a day, oral every night, the maximum dose of 10 mg per day of two groups of patients a course of treatment for 2 weeks, a total of 6 courses of treatment. The clinical efficacy, ADL and NPI-1NPI-2 scores, and the incidence of adverse drug reactions were compared between the two groups. Results after treatment, the total effective rates of the test group and the control group were 90.70 / 78 / 86 and 75.2929 / 64 / 85, respectively. The difference was statistically significant (P 0.01). 璇曢獙緇勫拰娌葷枟鍓嶅強娌葷枟絎，

本文編號：1904914