本文選題：海洛因 + 多巴胺轉(zhuǎn)運(yùn)體�。� 參考：《復(fù)旦大學(xué)》2013年碩士論文

【摘要】：第一部分 海洛因成癮者腦多巴胺轉(zhuǎn)運(yùn)體991Tc-TRODAT-lSPECT顯像研究 [目的]應(yīng)用99mTc-TRODAT-1SPECT顯像技術(shù),比較海洛因依賴者與正常志愿者紋狀體內(nèi)多巴胺轉(zhuǎn)運(yùn)體水平 [方法]招募21名健康志愿者(男14名,女7名)和23名海洛因依賴者(男18名,女5名)。海洛因依賴者生理性脫毒兩周后進(jìn)行心理渴求評(píng)分、漢密頓焦慮量表(HAMA)評(píng)分和漢密頓抑郁量表(HDMA)評(píng)分。所有受試者均為右利手,兩組受試者年齡、BMI均無顯著性差異。對(duì)健康志愿者和脫毒兩周海洛因依賴者進(jìn)行99mTc-TRODAT-1腦SPECT顯像。對(duì)SPECT圖像進(jìn)行三維重建,參照正常人MRI圖像相應(yīng)橫斷面,在SPECT圖像上對(duì)左側(cè)紋狀體、右側(cè)紋狀體、左側(cè)尾狀核、右側(cè)尾狀核、左側(cè)殼核和右側(cè)殼核進(jìn)行ROI勾畫,選取枕葉(OC)作為本底。計(jì)算的放射性攝取比值(Specific uptake ratios, SURs)=(ROI-OC)/OC。采用SPSS15.0軟件,進(jìn)行統(tǒng)計(jì)分析。 [結(jié)果]海洛因依賴者雙側(cè)紋狀體、尾狀核和殼核放射性攝取比值明顯低于正常對(duì)照組(左側(cè)紋狀體：1.33±0.17和1.97±0.41,t=6.63,P0.001；右側(cè)紋狀體：1.28±0.19和1.99±0.39,t=7.55,P(0.001：左側(cè)尾狀核：1.32±0.16和2.01±0.42,t=7.13,P(0.001：右側(cè)尾狀核：1.27±0.19和2.05±0.41,t=7.87,P(0.001：左側(cè)殼核：1.33±0.18和1.91±0.40,t=6.10,P0.001：右側(cè)殼核：1.28±0.19和1.93±0.38,t=7.14,P0.001)。海洛因依賴者生理性脫毒兩周后渴求、焦慮和抑郁評(píng)分平均值分別為：1.70±1.66,15.39±7.50和13.17±6.63。海洛因依賴者渴求、焦慮和抑郁評(píng)分與紋狀體、尾狀核和殼核放射性攝取比值均無顯著性差異(P0.05)。 [結(jié)論]實(shí)驗(yàn)結(jié)果說明長(zhǎng)期海洛因?yàn)E用會(huì)導(dǎo)致紋狀體內(nèi)多巴胺轉(zhuǎn)運(yùn)體的下降。這個(gè)結(jié)果表明長(zhǎng)期的海洛因成癮可能會(huì)損傷到腦的紋狀體多巴胺能神經(jīng)元。 第二部分 冰毒成癮者腦多巴胺轉(zhuǎn)運(yùn)體99mTc-TRODAT-1SPECT顯像研究 [目的]應(yīng)用99mTc-TRODAT-1SPECT顯像技術(shù),比較冰毒依賴者與正常志愿者紋狀體內(nèi)多巴胺轉(zhuǎn)運(yùn)體的改變 [方法]招募21名健康志愿者(男14名,女7名)和25名冰毒依賴者(男17名,女8名)。冰毒依賴者生理性脫毒兩周后進(jìn)行心理渴求評(píng)分、漢密頓焦慮量表評(píng)分和漢密頓抑郁量表評(píng)分。所有受試者均為右利手,兩組受試者年齡、BMI均無顯著性差異。對(duì)健康志愿者和脫毒兩周冰毒依賴者進(jìn)行99mTc-TRODAT-1腦SPECT顯像。對(duì)SPECT圖像進(jìn)行三維重建,參照正常人MRI圖像相應(yīng)橫斷面,在SPECT圖像上對(duì)左側(cè)紋狀體、右側(cè)紋狀體、左側(cè)尾狀核、右側(cè)尾狀核、左側(cè)殼核和右側(cè)殼核進(jìn)行ROI勾畫,選取枕葉(OC)作為本底。放射性攝取比值(SURs)=(ROI-OC)/OC。采用SPSS15.0軟件,進(jìn)行統(tǒng)計(jì)分析。 [結(jié)果]冰毒依賴者雙側(cè)紋狀體、尾狀核和殼核放射性攝取比值明顯低于正常對(duì)照組(左側(cè)紋狀體：1.24±0.31和1.97±0.41,t=6.80,P0.001；右側(cè)紋狀體：1.23±0.33和1.99±0.39,t=7.02,P〈0.001；左側(cè)尾狀核：1.26±0.33和2.01±0.42,t=6.84,P0.001：右側(cè)尾狀核：1.25±0.35和2.05±0.41,t=7.10,P0.001：左側(cè)殼核：1.22±0.31和1.91±0.40,t=6.62,P0.001；右側(cè)殼核：1.22±0.32和1.93±0.38,t=6.94,P0.001)。冰毒依賴者生理性脫毒兩周后渴求、焦慮和抑郁評(píng)分平均值分別為：3.96±1.97,21.36±10.56和15.92±8.24。冰毒依賴者渴求評(píng)分與右側(cè)紋狀體、右側(cè)尾狀核和右側(cè)殼核存在負(fù)相關(guān)(r分別為-0.40,-0.39和-0.41)。 [結(jié)論]長(zhǎng)期冰毒濫用會(huì)導(dǎo)致紋狀體內(nèi)多巴胺轉(zhuǎn)運(yùn)體的下降�；悠跔羁是蟪潭瓤赡芘c腦內(nèi)多巴胺轉(zhuǎn)運(yùn)體的下降有關(guān)。 第三部分 海洛因及冰毒依賴者腦多巴胺轉(zhuǎn)運(yùn)體改變的研究 [目的]應(yīng)用99mTc-TRODAT-1SPECT顯像技術(shù),比較海洛因依賴者與冰毒依賴者紋狀體內(nèi)多巴胺轉(zhuǎn)運(yùn)體的改變,同時(shí)比較兩組稽延期戒斷渴求、焦慮和抑郁的程度及關(guān)系 [方法]招募21名健康志愿者(男14名,女7名),23名海洛因依賴者(男18名,女5名)及25名冰毒依賴者(男17名,女8名)。海洛因和冰毒依賴者生理性脫毒兩周后進(jìn)行心理渴求評(píng)分、漢密頓焦慮量表評(píng)分和漢密頓抑郁量表評(píng)分。所有受試者均為右利手,三組受試者年齡、BMI均無顯著性差異。海洛因組和冰毒組吸毒時(shí)間、每天平均毒品用量均沒有顯著性差異。對(duì)健康志愿者、海洛因和冰毒依賴者脫毒兩周后進(jìn)行99mTc-TRODAT-1腦SPECT顯像。對(duì)SPECT圖像進(jìn)行三維重建,參照正常人MRI圖像相應(yīng)橫斷面,在SPECT圖像上對(duì)左側(cè)紋狀體、右側(cè)紋狀體、左側(cè)尾狀核、右側(cè)尾狀核、左側(cè)殼核和右側(cè)殼核進(jìn)行ROI勾畫,選取枕葉(OC)作為本底。放射性攝取比值(SURs)=(ROI-OC)/OC。采用SPSS15.0軟件,進(jìn)行統(tǒng)計(jì)分析。 [結(jié)果]正常對(duì)照組、海洛因組和冰毒組雙側(cè)紋狀體、尾狀核和殼核放射性攝取比值均存在顯著性差異(左側(cè)紋狀體：1.97±0.41,1.33±0.17和1.24±0.31,F=35.79,P0.05：右側(cè)紋狀體：1.99±0.39,1.28±0.19和1.23±0.33,F=40.13,P0.05：左側(cè)尾狀核：2.01±0.42,1.32±0.16和1.26±0.33,F=38.11,P0.05：右側(cè)尾狀核：2.05±0.41,1.27±0.19和1.25±0.35,F=42.07,P0.05；左側(cè)殼核：1.91±0.40,1.33±0.18和1.22±0.31,F=32.38,P0.05：右側(cè)殼核：1.93±0.38,1.28±0.19和1.22±0.32,F=37.12,P0.05)。相同濫用時(shí)間劑量情況下,海洛因依賴者與冰毒依賴者比較,雙側(cè)紋狀體、尾狀核和殼核放射性攝取比值沒有顯著性差異(左側(cè)紋狀體：P=0.32；右側(cè)紋狀體：P=0.64；左側(cè)尾狀核：P=-0.53；右側(cè)尾狀核：P=-0.82；左側(cè)殼核：P=-0.21；右側(cè)殼核：P=-0.52)。海洛因依賴者和冰毒依賴者渴求評(píng)分存在顯著性差異(t=-4.29,P0.05)；海洛因依賴者的漢密頓焦慮量表評(píng)分顯著低于冰毒依賴者(t=-2.27,P0.05)：海洛因依賴者和冰毒依賴者的漢密頓抑郁量表評(píng)分沒有顯著性差異(t=-1.27,P0.05)。 [結(jié)論]長(zhǎng)期海洛因和冰毒濫用會(huì)導(dǎo)致腦內(nèi)多巴胺轉(zhuǎn)運(yùn)體的下降。在吸毒時(shí)間和每日平均劑量沒有顯著性差異的情況下,兩種毒品引起的紋狀體多巴胺轉(zhuǎn)運(yùn)體的降低,并不存在顯著性差異。冰毒依賴者稽延期渴求、焦慮癥狀較海洛因依賴者更明顯。
[Abstract]:Part one
Dopamine transporter 991Tc-TRODAT-lSPECT imaging in heroin addicts
[Objective] to compare the level of dopamine transporter in striatum of heroin addicts and normal volunteers by 99mTc-TRODAT-1SPECT imaging.
[Methods] 21 healthy volunteers (14 men, 7 women) and 23 heroin addicts (18 men and 5 women) were recruited by heroin addicts for two weeks of physical detoxification, the Hamilton Anxiety Scale (HAMA) score and the Hamilton Depression Scale (HDMA) score. All the subjects were right hand, and the age of two groups, BMI were not obvious. 99mTc-TRODAT-1 brain SPECT imaging was performed on healthy volunteers and heroin addicts for two weeks of detoxification. Three-dimensional reconstruction of SPECT images and corresponding cross sections of normal human MRI images were performed on the left striatum, right striatum, left caudate nucleus, right caudate nucleus, left putamen and right putamen on SPECT images. The occipital lobe (OC) was selected as the background. The Specific uptake ratios (SURs) = (ROI-OC) /OC. was calculated by SPSS15.0 software and analyzed statistically.
[results] the ratio of radioactivity in the bilateral striatum, caudate nucleus and putamen was significantly lower than that of the normal control group (1.33 + 0.17 and 1.97 + 0.41, t=6.63, P0.001; right striatum: 1.28 + 0.19 and 1.99 + 0.39, t=7.55, P (0.001: 1.32 + 0.16 and 2.01 + 0.42, t=7.13, P (0.001: right caudate) Nucleus: 1.27 + 0.19 and 2.05 + 0.41, t=7.87, P (0.001: left putamen: 1.33 + 0.18 and 1.91 + 0.40, t=6.10, P0.001: 1.28 + 0.19 and 1.93 + 0.38, t=7.14, P0.001). The heroin dependent craving after physiological detoxification, the average of anxiety and depression scores were: 1.66,15.39 + 6.63. and 6.63. heroin dependence There was no significant difference in the craving, anxiety and depression scores between the striatum, the caudate nucleus and putamen radiation-uptake ratio (P0.05).
[Conclusion] the results suggest that long term heroin abuse leads to a decrease in dopamine transporter in the striate. This result suggests that long term heroin addiction may damage the striatum dopaminergic neurons in the brain.
The second part
Brain dopamine transporter 99mTc-TRODAT-1SPECT imaging in methamphetamine addicts
[Objective] to compare the changes of dopamine transporters in striatum of methamphetamine dependent volunteers and normal volunteers by 99mTc-TRODAT-1SPECT imaging.
[Methods] 21 healthy volunteers (14 men, 7 women) and 25 ice addicts (17 men and 8 women) were recruited. The psychosocial craving score, Hamilton Anxiety Scale score and Hamilton Depression Scale score were performed for two weeks after physiological detoxification of ice addicts. All subjects were right hand, and there was no significant difference in BMI between the two groups. 99mTc-TRODAT-1 brain SPECT imaging was performed in healthy volunteers and detoxified two weeks of ice addicts. Three-dimensional reconstruction of SPECT images and corresponding cross section of normal human MRI images were performed on the left striatum, right striatum, left caudate nucleus, right caudate nucleus, left putamen and right putamen in ROI to select the occipital lobe (OC) on SPECT images. Background. Radiation-uptake ratio (SURs) = (ROI-OC) /OC. was analyzed by SPSS15.0 software.
[results] the ratio of radioactivity in the bilateral striatum, caudate nucleus and putamen was significantly lower than that of the normal control group (1.24 + 0.31 and 1.97 + 0.41, t=6.80, P0.001; right striatum: 1.23 + 0.33 and 1.99 + 0.39, t=7.02, P < 0.001; 1.26 + 0.33 and 2.01 + 0.42, t=6.84, P0.001: right caudate nucleus. 1.25 + 0.35 and 2.05 + 0.41, t=7.10, P0.001: left putamen: 1.22 + 0.31 and 1.91 + 0.40, t=6.62, P0.001; right putamen: 1.22 + 0.32 and 1.93 + 0.38, t=6.94, P0.001). The score was negatively correlated with the right striatum, right caudate nucleus and right putamen (r = -0.40, -0.39 and -0.41).
[Conclusion] long-term abuse of ice can lead to a decrease in dopamine transporters in striatum. The extent of delayed phase craving may be related to the decrease of dopamine transporters in the brain.
The third part
Changes of dopamine transporter in heroin and methamphetamine addicts
[Objective] to compare the changes of dopamine transporter in heroin addicts and ice addicts in the striatum by 99mTc-TRODAT-1SPECT imaging, and compare the degree and relationship between the two groups of postponement abstinence craving, anxiety and depression.
[Methods] 21 healthy volunteers (14 men, 7 women), 23 heroin addicts (18 men, 5 women) and 25 ice addicts (17 men and 8 women) were recruited, and heroin and ice addicts were physically detoxified for two weeks after two weeks of psychological craving score, Hamilton Anxiety Scale score and Hamilton Depression scale. All the subjects were right-handed. There was no significant difference in the age of the three groups of subjects. There was no significant difference in the average dose of drugs between the heroin group and the ice group. The 99mTc-TRODAT-1 brain SPECT imaging was performed on the heroin and ice addicts after two weeks of detoxification. The three-dimensional reconstruction of the SPECT images was carried out with reference to the corresponding horizontal MRI image of the normal people. On the SPECT image, the left striatum, right striatum, left caudate nucleus, right caudate nucleus, left putamen and right putamen were examined by ROI to select the occipital lobe (OC) as the base. The radioactivity uptake ratio (SURs) = (ROI-OC) /OC. was analyzed by SPSS15.0 software.
[results] there were significant differences in the radioactivity ratio of bilateral striatum, caudate nucleus and putamen in both heroin group and ice group (1.97 + 0.41,1.33 + 0.17 and 1.24 + 0.31, F=35.79, P0.05: right striatum: 1.99 + 0.39,1.28 + 0.19 and 1.23 + 0.33, F=40.13, P0.05: 2.01 + 0.42,1.32 in left caudate nucleus. 0.16 and 1.26 + 0.33, F=38.11, P0.05: right caudate nucleus: 2.05 + 0.41,1.27 + 0.19 and 1.25 + 0.35, F=42.07, P0.05; left putamen: 1.91 + 0.40,1.33 + 0.18 and 1.22 +, F=32.38, P0.05: the right putamen: 1.93 + 0.38,1.28 + 0.19 and 1.22 + 1.25, F=37.12, P0.05). Heroin addicts and methamphetamine There was no significant difference in the ratio of radioactive uptake in the bilateral striatum, caudate nucleus and putamen (P=0.32; right striatum: P=0.64; left caudate nucleus: P=-0.53; right caudate nucleus: P=-0.82; left putamen: P=-0.21; right putamen: P= -0.52). Heroin addicts and ice addicts craving There were significant differences (t=-4.29, P0.05); the Hamilton Anxiety Scale of heroin addicts was significantly lower than that of ice addicts (t=-2.27, P0.05). There was no significant difference in the Hamilton Depression Scale between heroin addicts and ice addicts (t=-1.27, P0.05).
[Conclusion] long term heroin and methamphetamine abuse may lead to the decrease of dopamine transporter in the brain. There is no significant difference in the decrease of the striatum dopamine transporter caused by two drugs in the case of drug taking time and daily average dose. It is more obvious.

【學(xué)位授予單位】：復(fù)旦大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2013
【分類號(hào)】：R749.64;R817.4

【相似文獻(xiàn)】

相關(guān)期刊論文 前10條

1 龔昌海,王耀華,黃國平,羅明;785例海洛因依賴者多藥濫用情況調(diào)查[J];中國藥物濫用防治雜志;2004年01期

2 王佩蓉;海洛因依賴者應(yīng)付方式與社會(huì)支持狀況的調(diào)查[J];中國藥物濫用防治雜志;2004年01期

3 方曉云,俞連紅,任麗;海洛因依賴者自測(cè)健康及相關(guān)評(píng)定量表的應(yīng)用[J];中國行為醫(yī)學(xué)科學(xué);2004年01期

4 范小全,李志超;海洛因依賴者多藥濫用436例分析[J];中華全科醫(yī)師雜志;2004年01期

5 劉海龍,崔新華,連智;海洛因依賴者應(yīng)付方式研究[J];中國藥物依賴性雜志;2004年03期

6 蕭丹,劉夢(mèng)光,張玉萍,徐文貴;女性海洛因依賴者性激素變化的探討[J];中國實(shí)驗(yàn)診斷學(xué);2004年03期

7 周泉;;海洛因依賴者腦干聽覺誘發(fā)電位檢測(cè)30例報(bào)告[J];中國藥物濫用防治雜志;2006年05期

8 王文甫;沈亞強(qiáng);;海洛因依賴者住院脫毒期間死亡3例分析[J];中國藥物濫用防治雜志;2006年05期

9 鄭威;;難治性海洛因依賴者的脫毒1例報(bào)告[J];中國藥物濫用防治雜志;2006年05期

10 韓丹;;海洛因依賴者社會(huì)支持、應(yīng)對(duì)方式與心理健康的相關(guān)分析[J];中國藥物濫用防治雜志;2007年06期

相關(guān)會(huì)議論文 前10條

1 羅標(biāo)文;;海洛因依賴者口服六未加液臨床41例觀察分析[A];第四屆全國中西醫(yī)結(jié)合戒毒學(xué)術(shù)研討會(huì)教材、論文摘要集[C];2000年

2 盧秋芬;;海洛因依賴者藏藥方式及干預(yù)[A];中國心理衛(wèi)生協(xié)會(huì)殘疾人心理衛(wèi)生分會(huì)第六屆學(xué)術(shù)交流會(huì)論文集[C];2006年

3 王繼忠;李志民;余小玉;;126例海洛因依賴者患牙病情況的調(diào)查分析[A];第七屆全國藥物依賴性學(xué)術(shù)會(huì)議論文摘要匯編[C];2003年

4 李海清;;海洛因依賴者下肢靜脈血栓形成的原因與治療[A];第七屆全國藥物依賴性學(xué)術(shù)會(huì)議論文摘要匯編[C];2003年

5 范小全;李志超;;436例海洛因依賴者多藥濫用情況分析[A];第七屆全國藥物依賴性學(xué)術(shù)會(huì)議論文摘要匯編[C];2003年

6 楊會(huì);;110例海洛因依賴者抑郁的調(diào)查[A];第七屆全國藥物依賴性學(xué)術(shù)會(huì)議論文摘要匯編[C];2003年

7 姜祥智;;海洛因依賴者人格特征與心理健康相關(guān)分析[A];中華醫(yī)學(xué)會(huì)精神病學(xué)分會(huì)第九次全國學(xué)術(shù)會(huì)議論文集[C];2011年

8 周燕;查顯友;;600例海洛因依賴者心電圖變化異常分析[A];2011年浙江省醫(yī)學(xué)會(huì)精神病學(xué)分會(huì)學(xué)術(shù)年會(huì)暨浙江省醫(yī)師協(xié)會(huì)精神科醫(yī)師分會(huì)第四屆年會(huì)論文匯編[C];2011年

9 戴宏金;史有運(yùn);;柳州市1997年2715例海洛因依賴者流行學(xué)調(diào)查[A];第一屆全國藥物濫用流行病學(xué)研討會(huì)論文摘要匯編[C];1998年

10 張金橋;李品銀;;海洛因依賴者康復(fù)期猝死臨床急救分析[A];《中華急診醫(yī)學(xué)雜志》第九屆組稿會(huì)暨第二屆急診醫(yī)學(xué)青年論壇全國急危重癥與救援醫(yī)學(xué)學(xué)習(xí)班論文匯編[C];2010年

相關(guān)重要報(bào)紙文章 前3條

1 記者　 徐瑞哲;中藥“無毒戒療”在滬試點(diǎn)[N];解放日?qǐng)?bào);2006年

2 符月;東莨菪堿可控制海洛因依賴者的急性戒斷癥狀[N];中國醫(yī)藥報(bào);2002年

3 記者　李穎 通訊員　解雯;中藥“無毒戒療”改變國際主流戒毒法[N];科技日?qǐng)?bào);2006年

相關(guān)博士學(xué)位論文 前1條

1 劉克菊;男性海洛因依賴者社區(qū)康復(fù)訓(xùn)練療效研究及海洛因渴求問卷初步編制[D];中南大學(xué);2003年

相關(guān)碩士學(xué)位論文 前10條

1 宋紅霞;海洛因依賴者生活質(zhì)量影響因素及連續(xù)護(hù)理干預(yù)[D];天津醫(yī)科大學(xué);2010年

2 羅濤;登仁橋社區(qū)海洛因依賴者的質(zhì)性研究[D];中南大學(xué);2011年

3 馬小琴;海洛因依賴者人格特征與性功能的研究分析[D];浙江大學(xué);2002年

4 喬聚耀;海洛因依賴者及其一級(jí)親屬的三維人格特征研究[D];四川大學(xué);2006年

5 梁劍芳;自愿戒毒的海洛因依賴者生命質(zhì)量與心理健康狀況及其相關(guān)因素的研究[D];第一軍醫(yī)大學(xué);2004年

6 王二磊;線索誘發(fā)不同戒斷期海洛因依賴者渴求的功能磁共振研究[D];遵義醫(yī)學(xué)院;2011年

7 柳瑞;海洛因依賴者海馬功能的磁共振研究[D];昆明醫(yī)學(xué)院;2008年

8 王帆;海洛因依賴者執(zhí)行功能與沖動(dòng)型人格特質(zhì)的關(guān)系研究[D];廣州大學(xué);2012年

9 謝春明;視覺“線索”誘發(fā)渴求狀態(tài)的腦功能研究[D];中國人民解放軍軍事醫(yī)學(xué)科學(xué)院;2005年

10 劉光雄;海洛因依賴者注意偏向的行為學(xué)及ERP研究[D];第四軍醫(yī)大學(xué);2009年

，

本文編號(hào)：1807048