本文選題：甲狀腺抗體　切入點：甲狀腺功能　出處：《大連醫(yī)科大學》2014年碩士論文

【摘要】：目的：近年來慢性淋巴細胞性甲狀腺炎的發(fā)病率、抑郁癥的發(fā)病率均持續(xù)上升，相關資料提示我們慢性淋巴細胞性甲狀腺炎與抑郁有共同的發(fā)病機制，他們存在關聯(lián)，我們通過我院門診就診的患者進行分組，研究兩者的發(fā)病情況。 方法：選取在大連大學附屬中山醫(yī)院內(nèi)分泌科門診符合實驗入選條件的患者，年齡范圍選擇能完成抑郁評分者，性別隨機。將符合實驗入選條件的病例按抗甲狀腺抗體陽性和甲狀腺功能正常和異常分為實驗組和實驗對照組，抗甲狀腺抗體陰性和甲狀腺功能正常的患者作為對照組。對所有入選研究對象的資料進行整理，記錄年齡、性別、教育程度、職業(yè)、婚姻情況等。將收集到的病例按實驗分組的標準分到各個組中，進行抑郁評分，抑郁評分的方法采用漢密頓抑郁量表統(tǒng)計。對各組抑郁評分和嚴重程度進行相關性分析。 結果：1）年齡因素與正常對照組相比，實驗組、實驗對照組年齡小十余歲，兩個實驗組的平均年齡相差不大。2）性別因素與正常對照組相比，實驗組男性居多。3）生活狀態(tài)三組無統(tǒng)計學差異。4）職業(yè)情況從事教育、文職類工作的人數(shù)在三組中的分布比較接近，其他無明顯規(guī)律。5）受教育程度兩個實驗組相對于正常對照組，受高等教育水平的人數(shù)接近并略高。6）甲狀腺功能及抗甲狀腺抗體水平與正常對照組相比，，實驗組甲狀腺抗體升高；與實驗組相比，實驗對照組，甲狀腺功能升高，存在統(tǒng)計學差異（P＜0.01）。7）抑郁評分實驗組和實驗對照組明顯高于對照組，有統(tǒng)計學差異（P＜0.01）。實驗組與實驗對照組的抑郁得分的平均分結果沒有統(tǒng)計學差別（P＞0.05）。8）抑郁程度抑郁評分小于8時（表示為正常狀態(tài)），正常對照組人數(shù)高于實驗組和實驗對照組，存在統(tǒng)計學差異（P＜0.01）；抑郁評分為8-20（輕度抑郁）和20-35（中度抑郁）時人數(shù)比例，對照組低于實驗組和實驗對照組，有統(tǒng)計學差異（P＜0.05），但兩實驗組差別不大。 結論：通過資料分析，表明慢性自身免疫性甲狀腺炎與抑郁癥有關聯(lián)，兩者關聯(lián)的主要因素是免疫功能障礙，但與是否有甲狀腺功能異常關系不大。
[Abstract]:Objective: in recent years, the incidence of chronic lymphocytic thyroiditis rate, the incidence of depression increased continually, relevant information suggests that chronic lymphocytic thyroiditis and depression have a common pathogenesis, they are related, we through the clinic of our hospital patients were divided into two groups, the incidence of the two.
Methods: in Dalian University affiliated Zhongshan Hospital Department of Endocrinology outpatient department in accordance with the experimental conditions were selected, the age range of choice to complete depression scores, gender randomly selected condition. Meet the test cases according to anti thyroid antibodies and thyroid function of normal and abnormal divided into experimental group and experimental control group, negative anti thyroid antibodies and thyroid function normal patients as control group. All the selected research object data, record the age, gender, education, occupation, marital status and so on. The collected cases according to experimental group standards assigned to each group, depression score, depression score using the statistics method of Hamilton Depression Rating. The correlation analysis of each depression score and severity.
Results: 1) the age factor compared with normal control group, experimental group, experimental control group of age more than 10 years old, the average age of the two experimental groups had similar gender.2) compared with the normal control group, experimental group.3) male life no statistical difference between the three groups of.4) in the number of civilian occupation education. The work of the distribution in the three groups comparing to the other, no obvious rule.5) education in two experimental groups compared with normal control group, the number of higher education level is close to and slightly higher.6) thyroid function and anti thyroid antibody levels compared with normal control group, the experimental group increased compared with thyroid antibodies; the experimental group, experimental control group, thyroid function increased, there was significant difference (P < 0.01).7) depression score in experimental group and experimental control group was significantly higher than the control group, there was significant difference (P < 0.01). The experimental group and the experiment of According to the group average depression scores did not result in statistically significant difference (P > 0.05).8) depression depression score is less than 8 (expressed as normal), the number is higher than the normal control group experimental group and experimental control group, there was significant difference (P < 0.01); depression score was 8-20 (mild depression) and 20-35 (moderate depression) when the ratio of the number, the control group than in the experimental group and experimental control group, there was significant difference (P < 0.05), but the two experimental group difference.
Conclusion: through the analysis of data showed that associated with chronic autoimmune thyroiditis and depression, two main factors associated with immune dysfunction, but whether there is abnormal thyroid function has little relationship.

【學位授予單位】：大連醫(yī)科大學
【學位級別】：碩士
【學位授予年份】：2014
【分類號】：R581.4;R749.4

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