本文選題：抑郁癥　切入點(diǎn)：細(xì)胞因子　出處：《中國老年學(xué)雜志》2014年24期

【摘要】：目的探討老年抑郁癥患者外周血白細(xì)胞介素(IL)2、-1β、-6、腫瘤壞死因子(TNF-α)水平變化及其意義。方法采用ELISA檢測(cè)首發(fā)老年抑郁癥患者44例(抑郁癥組)、健康老年人36例(對(duì)照組)外周血IL-6、IL-2、IL-1β、TNF-α水平。結(jié)果抑郁癥組IL-2、IL-1β、IL-6分別為(48.502±11.266)、(8.910±19.818)、(1.478±1.456)ng/L,與正常組〔(49.713±11.800)、(31.615±71.815)、(1.478±1.456)ng/L〕比較無顯著差異;抑郁癥組與正常組TNF-α分別為(5.095±4.661)、(2.227±2.036)ng/L,具有統(tǒng)計(jì)學(xué)意義(P0.01)。TNF-α相關(guān)系數(shù)0.297,P=0.008。老年抑郁癥組IL-2、IL-1β、IL-6、TNF-αROC曲線下面積分別為0.479、0.384、0.505、0.671,P值分別為0.750、0.074、0.934、0.009。結(jié)論 TNF-α參與了老年抑郁癥的發(fā)生和發(fā)展,TNF-α為老年抑郁癥的免疫學(xué)標(biāo)志之一。
[Abstract]:Objective to investigate the elderly patients with depression of peripheral blood interleukin 2 beta (IL), -1, -6, tumor necrosis factor alpha (TNF- alpha) level changes and significance. Methods to detect 44 cases of first-episode senile depression in patients with ELISA (depression group), 36 healthy elderly (control group) of peripheral blood IL-6, IL-2 IL-1, beta, TNF- alpha level. The depression group IL-2, IL-1 beta, IL-6 respectively (48.502 + 11.266), (8.910 + 19.818), (1.478 + 1.456) ng/L, and the normal group (49.713 + 11.800), (31.615 + 71.815), (1.478 + 1.456) ng/L compared. The differences between the depression group and normal group; the TNF- alpha were (5.095 + 4.661), (2.227 + 2.036) ng/L, with statistical significance (P0.01).TNF- a correlation coefficient of 0.297, P=0.008. of senile depression group IL-2, IL-1 IL-6, TNF- alpha beta, the area under the ROC curve were 0.479,0.384,0.505,0.671 and P respectively 0.750,0.074,0.934,0.009. conclusion TNF- participate the senile depression The occurrence and development of TNF- A is one of the immunological markers of senile depression.

【作者單位】： 新疆維吾爾自治區(qū)人民醫(yī)院臨床心理科;新疆維吾爾自治區(qū)人民醫(yī)院檢驗(yàn)科;
【基金】：國家自然科學(xué)基金地區(qū)科學(xué)基金項(xiàng)目(81260212)
【分類號(hào)】：R749.4

【參考文獻(xiàn)】

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本文編號(hào)：1706047