發(fā)布時(shí)間：2018-03-15 19:39

  本文選題：多線圈陣列　切入點(diǎn)：弱磁刺激　出處：《天津大學(xué)》2014年碩士論文　論文類(lèi)型：學(xué)位論文

【摘要】：無(wú)創(chuàng)式腦刺激技術(shù)被廣泛應(yīng)用在腦功能的研究中，并成為治療神經(jīng)精神疾病的有效方法之一。精神疾病的早期診斷是治療的關(guān)鍵所在，但目前缺少早期診斷的客觀量化參數(shù)。因此本文提出一種可控磁刺激與腦功能成像相結(jié)合的思想，以期獲得量化腦功能參數(shù)。 基于系統(tǒng)辨識(shí)的思想，本文首次提出弱磁場(chǎng)、可變刺激區(qū)域、可調(diào)參數(shù)的多線圈陣列磁刺激結(jié)合的腦功能探測(cè)分析平臺(tái)。平臺(tái)以磁刺激作為輸入，作為輸出，構(gòu)成一個(gè)大腦功能的探測(cè)系統(tǒng)。本文給出了磁刺激系統(tǒng)的總體構(gòu)架，包括上位機(jī)、控制電路及刺激主電路等環(huán)節(jié)。 基于電磁刺激可以影響大腦神經(jīng)電活動(dòng)的機(jī)理，本文使用軟件，詳細(xì)分析多線圈陣列磁刺激在頭部的感應(yīng)電磁場(chǎng)分布。從刺激電流幅值、刺激電流變化時(shí)間、刺激電流方向、激活線圈的不同組合形式等四個(gè)方面進(jìn)行了詳細(xì)的電磁仿真并對(duì)結(jié)果進(jìn)行分析。通過(guò)分析證明多線圈陣列能實(shí)現(xiàn)單圓型線圈、八字線圈、線圈陣列等多種刺激形式。刺激區(qū)域可以達(dá)到整個(gè)大腦或特定區(qū)域，滿足多種探測(cè)腦功能要求。 根據(jù)探測(cè)系統(tǒng)刺激的要求，本文設(shè)計(jì)了多線圈陣列的控制系統(tǒng)，實(shí)現(xiàn)刺激電流可變，刺激磁場(chǎng)可調(diào)及刺激線圈可控等功能。對(duì)于刺激電流輸出部分，設(shè)計(jì)了基于可控開(kāi)關(guān)的全橋電路，，可以生成單向、雙向、簇脈沖形式的刺激電流波形。為了實(shí)現(xiàn)刺激磁場(chǎng)可調(diào)，本文采用帶電壓環(huán)補(bǔ)償?shù)纳祲簲夭娐�，能夠根�?jù)磁場(chǎng)強(qiáng)度自動(dòng)調(diào)節(jié)輸出電壓，產(chǎn)生不同強(qiáng)度的刺激電磁場(chǎng)。最后針對(duì)刺激線圈可控，提出了基于雙向可控硅和光電耦合器的控制方案。對(duì)于以上設(shè)計(jì)方案，給出了電路仿真結(jié)果。 本文設(shè)計(jì)的多線圈陣列磁刺激系統(tǒng)，為探測(cè)大腦功能和精神疾病的早期診斷提供了一種新的刺激方案。
[Abstract]:Non-invasive brain stimulation technology has been widely used in the study of brain function and has become one of the effective methods for the treatment of neuropsychiatric diseases. The early diagnosis of mental disorders is the key to the treatment. However, there is a lack of objective quantitative parameters for early diagnosis, so this paper presents an idea of combining controllable magnetic stimulation with brain functional imaging in order to obtain quantized brain function parameters. Based on the idea of system identification, this paper for the first time proposes a brain function detection and analysis platform based on weak magnetic field, variable stimulus region, adjustable parameters and multi-coil array magnetic stimulation. The platform uses magnetic stimulation as input and output. This paper presents the general framework of magnetic stimulation system, including upper computer, control circuit and stimulus main circuit. Based on the mechanism that electromagnetic stimulation can affect the electrical activity of brain, the distribution of inductive electromagnetic field of multi-coil array magnetic stimulation in the head is analyzed in detail by using software. The amplitude of stimulation current, the change time of stimulation current, the direction of stimulation current, the distribution of inductive electromagnetic field of multi-coil array magnetic stimulation are analyzed in detail. Four aspects such as different combinations of active coils are carried out in detail and the results are analyzed. It is proved that the multi-coil array can realize single circular coils, eight-character coils, and so on. Coil array and other stimuli. The stimuli can reach the whole brain or a specific region, and meet the requirements of a variety of brain function detection. According to the requirement of detecting system stimulation, the control system of multi-coil array is designed in this paper, which realizes the functions of variable stimulus current, adjustable magnetic field and controllable stimulation coil. A full bridge circuit based on controllable switch is designed, which can generate the stimulus current waveform in the form of unidirectional, bidirectional and cluster pulses. In order to realize the adjustable magnetic field of the stimulus, this paper uses a voltage loop compensated voltage chopper circuit. The output voltage can be automatically adjusted according to the intensity of the magnetic field, and the exciting electromagnetic field with different intensity can be generated. Finally, a control scheme based on bidirectional thyristor and optocoupler is proposed to control the stimulation coil. The simulation results are given. The multicoil array magnetic stimulation system designed in this paper provides a new stimulus scheme for the early diagnosis of brain function and mental illness.
【學(xué)位授予單位】：天津大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類(lèi)號(hào)】：TP391.9;R749

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