發(fā)布時間：2018-01-31 20:20

  本文關(guān)鍵詞： 抑郁癥 過敏癥 細胞因子 Meta分析 人群調(diào)查　出處：《華中師范大學(xué)》2013年碩士論文　論文類型：學(xué)位論文

【摘要】：過敏癥是一種普遍存在、影響甚廣的疾病,它指的是當機體處于Ⅰ型變態(tài)反應(yīng)時的病理學(xué)狀態(tài)時,由Ⅰ型變態(tài)反應(yīng)引起的疾病,包括：過敏性鼻炎、過敏性胃腸炎、蕁麻疹、哮喘、和過敏性休克等疾病,統(tǒng)稱為過敏癥[1]在諸多的過敏癥中,以哮喘最為重要,發(fā)病嚴重時可以致人于死地,并已經(jīng)造成了世界性的醫(yī)療經(jīng)濟負擔[2]侵入體內(nèi)的環(huán)境過敏原和患者自身的過敏體質(zhì)是發(fā)病的主要的病因。過敏原主要包括：室內(nèi)的螨蟲、蟑螂糞便和尸體碎片、寵物皮屑、霉菌及其代謝產(chǎn)物、室外樹/花粉和食物中的某些蛋白質(zhì)等,當它們侵入人體之后,使那些過敏體質(zhì)患者的機體免疫系統(tǒng)發(fā)生活化,產(chǎn)生針對這些過敏原的特異性的細胞因子,然后進一步產(chǎn)生Ⅰ型變態(tài)反應(yīng),俗稱“過敏反應(yīng)”[3]。目前已知某些細胞因子和免疫細胞在過敏反應(yīng)中起重要作用。過敏癥的客觀生物標志物主要有：免疫球蛋白IgE,腫瘤壞死因子TNF-a,白細胞介素IL-1,IL-2,IL-4,IL-6,干擾素IFN-r等[4] 抑郁癥(Depression, DEP)是一種嚴重影響人們身心健康的精神疾病。近年來,抑郁癥的發(fā)病率逐漸上升,抑郁癥相關(guān)研究越來越受到人們的重視。人群中,大概有4%-20%的人在一生中的某個時期會受到抑郁的影響,導(dǎo)致個體的情感、思維、人際交往、生理機能、行為等障礙[5]抑郁癥屬于情感性的精神障礙,其發(fā)病機制十分復(fù)雜,是由多種原因引起的以心境障礙為主要病癥的綜合征。近代醫(yī)學(xué)研究表明精神健康生理狀況密切相關(guān)。據(jù)文獻報道,一些免疫細胞如單核細胞,肥大細胞,T淋巴細胞等細胞核細胞因子的抑郁癥發(fā)病進程中起重要調(diào)節(jié)作用[6] 有文獻指出,過敏人群患精神疾病的風險較正常人群偏高[7]于此同時,心理壓力和負面情緒也會導(dǎo)致機體的免疫指標表達異常。這意味著,過敏癥和抑郁癥存在某種關(guān)聯(lián)性,而免疫反應(yīng)很可能是這種關(guān)聯(lián)性的重要答案。過敏癥和抑郁癥可能山一些共同的細胞因子和免疫細胞參與調(diào)控。為了驗證過敏癥和抑郁癥的相關(guān)性,探索其發(fā)病機制的內(nèi)在聯(lián)系,本研究主要做了如下工作：1)檢索文獻,通過Meta分析,鎖定6種分子(IL-1,IL-4,IL-6,Ig-E,TNF-α,5-HT)作為本研究的生物指標；2)在武漢地區(qū)6所重點高校中的近6000人中進行了網(wǎng)絡(luò)問卷調(diào)查,分析調(diào)查數(shù)據(jù),發(fā)現(xiàn)武漢大學(xué)生人群中抑郁癥與過敏反應(yīng)具有高度相關(guān)性；2)在6000人樣本中隨機篩選出100例抑郁癥樣本和120例健康樣本抽血,通過ELISA方法檢測血液中的6種分子(IL-1,IL-4,IL-6,Ig-E,TNF-a,5-HT),發(fā)現(xiàn)與對照組相比,抑郁患者體內(nèi)的IL-1,IL-4,TNF-a表達量顯著增加,IL-6,5-HT表達量顯著降低,而Ig-E表達量無明顯差異。這說明,過敏癥與抑郁癥具有顯著相關(guān)性,并且是由IL-1,IL-4,IL-6,TNF-a,5-HT共同調(diào)節(jié)起作用的。
[Abstract]:Hypersensitivity is a widespread and widespread disease. It refers to diseases caused by type I allergies when the body is in the pathological state of type I allergy, including allergic rhinitis. Allergic gastroenteritis, urticaria, asthma, and anaphylactic shock, collectively known as allergies. [Of all the allergies, asthma is the most important, which can kill people when it is serious, and has caused a worldwide medical financial burden. [2) the environmental allergens invading the body and the allergic constitution of the patients are the main causes of the disease. The allergens mainly include: indoor mites, cockroach feces and corpse fragments, pet dandruff, mold and their metabolites. Outdoor trees / pollen and certain proteins in food, etc., when they invade the human body, activate the immune system of those with allergies and produce specific cytokines for these allergens. And then further develop type I allergic reactions, commonly known as "allergic reactions." [3] .Some cytokines and immune cells have been known to play an important role in allergic reactions. The objective biomarkers of allergies are immunoglobulin IgE and tumor necrosis factor TNF-a. Interleukin-1 Interleukin-2 Interleukin-2 Interleukin-6, Interferon IFN-r, etc. [4] Depression (DEP) is a mental disease that seriously affects people's physical and mental health. In recent years, the incidence of depression has gradually increased. Depression related research has been paid more and more attention. In the crowd, about 4- 20% of people will be affected by depression at some time in their life, leading to individual emotion, thinking, interpersonal interaction. Physical function, behavior, etc. [Depression is a kind of affective mental disorder, and its pathogenesis is very complicated. Modern medical studies have shown that mental health is closely related to physiological conditions. According to literature, some immune cells such as monocytes and mast cells are reported. Role of T lymphocyte and nuclear cytokines in the pathogenesis of depression. [6] It is pointed out in the literature that the risk of mental illness in allergic people is higher than that in normal people. [At the same time, psychological stress and negative emotions can also lead to abnormal expression of immune indicators in the body. This means that there is some association between allergies and depression. The immune response is probably an important answer to this association. Allergies and depression may be regulated by some common cytokines and immune cells. In order to verify the relationship between allergies and depression. To explore the internal relationship of its pathogenesis, the main work of this study was to search the literature as follows: 1) and through Meta analysis, we identified six molecules, IL-4, IL-4, IL-6, and Ig-E. TNF- 偽 (5-HT) as a biological index in this study; 2) A network questionnaire survey was conducted among nearly 6000 students in 6 key universities in Wuhan, and the data were analyzed. It was found that there was a high correlation between depression and allergic reaction among Wuhan college students. 2) 100 cases of depression and 120 cases of healthy blood were randomly selected from 6 000 samples, and 6 kinds of IL-1 IL-4 in blood were detected by ELISA method. Compared with the control group, the expression of IL-1, IL-4 and TNF-a increased significantly in patients with depression. The expression of 5-HT was significantly decreased, but there was no significant difference in the expression of Ig-E, which indicated that there was a significant correlation between hypersensitivity and depression, and it was IL-6 / TNF-a. 5-HT acts as a co-regulator.
【學(xué)位授予單位】：華中師范大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2013
【分類號】：R749.4;R593

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本文編號：1479918