本文關(guān)鍵詞：阿坎酸治療酒依賴(lài)的療效與安全性分析　出處：《暨南大學(xué)》2015年碩士論文　論文類(lèi)型：學(xué)位論文

  更多相關(guān)文章： 酒依賴(lài) 阿坎酸 隨機(jī)對(duì)照試驗(yàn) Meta分析

【摘要】：目的:評(píng)價(jià)阿坎酸治療酒依賴(lài)的療效及安全性。方法:檢索Pubmed、Web of Science、EMbase、The Cochrane Central Register of Controlled Trials、The Cochrane Library、中國(guó)科技期刊數(shù)據(jù)庫(kù)(維普)、相關(guān)期刊論文(CNKI)、萬(wàn)方全文數(shù)據(jù)庫(kù)等關(guān)于阿坎酸治療酒依賴(lài)的臨床隨機(jī)對(duì)照研究,采用Rev Man 5.2.0軟件對(duì)入選研究進(jìn)行Meta分析。結(jié)果:共納入27個(gè)隨機(jī)對(duì)照試驗(yàn)(RCT),包含6839例酒依賴(lài)患者。Meta分析結(jié)果顯示:①與安慰劑比較,阿坎酸可以減少12%的患者再度飲酒(RR:0.88,95%CI:0.83~0.93,P0.00001),并延長(zhǎng)累計(jì)戒酒時(shí)間(MD:10.66,95%CI:4.93~16.39,P=0.0003);根據(jù)治療時(shí)間分(2-4)月、6月、12月三個(gè)亞組,結(jié)果提示隨治療時(shí)間延長(zhǎng)阿坎酸的治療效益增大(RR:0.90,RR:0.86,RR:0.86;MD=8.40,MD=8.94,MD=12.24);②在再度重度飲酒率及GGT水平方面,阿坎酸與安慰劑比較無(wú)明顯統(tǒng)計(jì)學(xué)差異(RR:0.98,95%CI:0.93~1.04,P=0.52;MD:-10.7,95%CI:-22.3~0.89,P=0.07);根據(jù)治療時(shí)間進(jìn)行亞組分析,結(jié)果仍無(wú)統(tǒng)計(jì)學(xué)差異;③在不良反應(yīng)方面,阿坎酸組僅腹瀉發(fā)生率高于安慰劑組(P0.00001),而腹痛、便秘、惡心、嘔吐、瘙癢、頭痛、失眠發(fā)生率阿坎酸組與安慰劑組之間無(wú)明顯統(tǒng)計(jì)學(xué)差異。結(jié)論:阿坎酸可以降低酒依賴(lài)患者的再度飲酒率,延長(zhǎng)累計(jì)戒酒時(shí)間,且隨治療時(shí)間的延長(zhǎng)治療效益增大,但不能降低再度重度飲酒率,不良反應(yīng)少,可以作為酒依賴(lài)患者的治療藥物。
[Abstract]:Objective: to evaluate the efficacy and safety of arcanic acid in the treatment of alcohol dependence. The Cochrane Central Register of Controlled Trials. The Cochrane Library, China Science and Technology Journal Database. Wanfang Full-text Database and other clinical randomized controlled studies on the treatment of alcohol dependence with acanolic acid. Rev Man 5.2.0 software was used to analyze the Meta of the selected study. Results: a total of 27 randomized controlled trials were conducted. A meta-analysis of 6839 patients with alcohol dependence showed that Acanic acid could reduce the amount of alcohol consumed by 12% patients by 12% compared with placebo by RR: 0.88. 95 CI: 0.83 + 0.93% P0.00001, and the cumulative abstinence time should be increased to 10. 66% and 95% CI: 4.93% 16.39. P0. 0003; According to the treatment time divided into 2-4) months, June, December, three subgroups, the results showed that with the prolongation of the treatment time, the therapeutic benefits of arcanic acid increased with the increase of RR: 0.90% RR: 0.86. RR: 0.86; MDS 8.40, MDN 8.94, MDN 12.24; (2) there was no significant difference in the rate of heavy drinking and the level of GGT between arcanic acid and placebo. There was no significant difference in RR: 0.98 and 95% CI: 0.931.04% P0.52; MD: -10.7 and 95CI: -22.30.89% P0.07; The results of subgroup analysis were not statistically different according to the time of treatment. 3The incidence of diarrhea in acanic acid group was higher than that in placebo group (P 0.00001), but abdominal pain, constipation, nausea, vomiting, itching and headache. There was no significant difference in the incidence of insomnia between the arcanic acid group and the placebo group. Conclusion: arcanic acid can reduce the alcohol consumption rate in patients with alcohol dependence and prolong the cumulative abstinence time. With the prolongation of treatment time, the benefit of treatment increases, but it can not reduce the rate of heavy drinking again, and the adverse reaction is less, so it can be used as a therapeutic drug for patients with alcohol dependence.
【學(xué)位授予單位】：暨南大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2015
【分類(lèi)號(hào)】：R749.62

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