本文關(guān)鍵詞：精神病超高危人群認(rèn)知功能和心理狀況的比較研究　出處：《南方醫(yī)科大學(xué)》2015年碩士論文　論文類型：學(xué)位論文

  更多相關(guān)文章： 精神病超高危 認(rèn)知功能 精神分裂癥 心理狀況 內(nèi)表型

【摘要】：目的：通過精神病超高危組、高危組、首發(fā)精神分裂癥組、復(fù)發(fā)精神分裂癥組認(rèn)知功能和心理狀況的比較,分析精神病超高危人群的神經(jīng)認(rèn)知功能和心理狀況與其他人群的差異,尋找潛在的精神病理學(xué)相關(guān)的內(nèi)表型指標(biāo),為實(shí)現(xiàn)亞臨床特征(subclinical trait)或前驅(qū)期(prodromal)的早期識(shí)別、診斷及精神病超高危干預(yù)提供依據(jù),改善不良預(yù)后,減少功能殘疾。方法：分別收集符合入組和排除標(biāo)準(zhǔn)的40例精神分裂癥一級(jí)親屬精神病超高危受試者、40例精神分裂癥一級(jí)親屬高危組、40例首發(fā)精神分裂癥患者、40例復(fù)發(fā)精神分裂癥患者、40例健康對(duì)照組作為研究對(duì)象。所有研究對(duì)象入組后完成以下項(xiàng)目：(1)一般情況及精神病理癥狀：一般情況采用自制的一般人口學(xué)資料調(diào)查表；癥狀學(xué)評(píng)估采用Montgomery-Asberg抑郁量表(MADRS)、陽(yáng)性和陰性癥狀量表(PANSS)。(2)社會(huì)心理評(píng)估：采用兒童期經(jīng)歷問卷、家庭親密度和適應(yīng)性量表、生活事件量表、社會(huì)支持量表、盧森堡自尊量表、應(yīng)付方式量表等心理評(píng)估工具。(3)神經(jīng)認(rèn)知功能評(píng)估：采用連線測(cè)驗(yàn)(the Trail Making Test Part A, TMTA)、符號(hào)編碼(Symbol coding Test)、霍普金斯詞語(yǔ)學(xué)習(xí)測(cè)驗(yàn)修訂版(Hopkins Verbal Learning Test-Revised, HVLT-R)、簡(jiǎn)易視覺記憶測(cè)驗(yàn)修訂版(Brief Visuospatial Memory Test-Revised, BVMT-R)、Stroop色詞測(cè)驗(yàn)(Stroop Color WordTest, Stroop C-W)、持續(xù)操作測(cè)驗(yàn)(Continuous Performance Test, CPT)等認(rèn)知功能測(cè)驗(yàn)。主要比較精神病超高危組在認(rèn)知功能及心理狀況方面與其他各組的差異。結(jié)果：1.癥狀學(xué)比較結(jié)果：(1)抑郁癥狀比較結(jié)果：精神病超高危組抑郁情況好于首發(fā)精神分裂癥組和復(fù)發(fā)精神分裂癥組,差于高危組和健康對(duì)照組,具有統(tǒng)計(jì)學(xué)意義(p0.05);(2)PANSS量表比較結(jié)果：精神病超高危組情況要好于首發(fā)精神分裂癥組和復(fù)發(fā)精神分裂癥組,但比高危組和健康對(duì)照組差,具有統(tǒng)計(jì)學(xué)意義(p＜0.05)。2.社會(huì)心理學(xué)比較結(jié)果：(1)兒童期經(jīng)歷問卷結(jié)果表明,精神病超高危組在兒童期經(jīng)歷得分方面顯著低于首發(fā)精神分裂癥組、復(fù)發(fā)精神分裂癥組、健康對(duì)照組,有統(tǒng)計(jì)學(xué)意義p0.05),與高危組之間不存在顯著差異(p＜0.05)；(2)家庭親密度和適應(yīng)性量表結(jié)果表明,在親密度得分方面,精神病超高危組、高危組、首發(fā)精神分裂癥組、復(fù)發(fā)精神分裂癥組四組之間不存在顯著差異(p＜0.05),但是健康對(duì)照組顯著高于其他各組。在適應(yīng)性得分方面,精神病超高危組、健康對(duì)照組得分顯著高于高危組、首發(fā)精神分裂癥組和復(fù)發(fā)精神分裂癥組, 具有統(tǒng)計(jì)學(xué)意義(p0.05)；(3)生活事件量表結(jié)果表明,生活事件量表各維度得分方面不存在顯著的差異(p0.05)；(4)社會(huì)支持量表結(jié)果表明,精神病超高危組、高危組得分顯著高于首發(fā)精神分裂癥組和復(fù)發(fā)精神分裂癥組得分,健康對(duì)照組得分最高,具有統(tǒng)計(jì)學(xué)意義(p＜0.05)；(5)盧森堡自尊量表結(jié)果表明,精神病超高危組得分與健康對(duì)照組得分沒有顯著差異(p＜0.05),但是顯著高于高危組、首發(fā)精神分裂癥組和復(fù)發(fā)精神分裂癥組(p0.05)；(6)應(yīng)付方式量表結(jié)果表明,在合理化維度五組間無統(tǒng)計(jì)學(xué)意義(p0.05),在解決問題維度,精神病超高危組、高危組和健康對(duì)照組得分顯著高于復(fù)發(fā)精神分裂癥組得分,復(fù)發(fā)精神分裂癥組得分又顯著高于首發(fā)精神分裂癥組得分；在自責(zé)方面,精神病超高危組、高危組和健康對(duì)照組得分顯著低于首發(fā)精神分裂癥組和復(fù)發(fā)精神分裂癥組得分；在求助方面,精神病超高危組、高危組和健康對(duì)照組得分顯著低于首發(fā)精神分裂癥組和復(fù)發(fā)精神分裂癥組得分；在幻想方面,健康對(duì)照組得分顯著低于其他幾組的得分；在退避方面,健康對(duì)照組得分顯著低于高危組、首發(fā)精神分裂癥組和復(fù)發(fā)精神分裂癥組得分。3.神經(jīng)認(rèn)知功能比較結(jié)果：(1)在連線測(cè)驗(yàn)(TMTA)方面方面,精神病超高危組得分顯著短于首發(fā)精神分裂癥組和復(fù)發(fā)精神分裂癥組,但比高危組和健康對(duì)照組用時(shí)長(zhǎng),具有統(tǒng)計(jì)學(xué)意義(p0.05)；(2)在符號(hào)編碼方面,精神病超高危組得分高于首發(fā)精神分裂癥組和復(fù)發(fā)精神分裂癥組,但低于高危組和健康對(duì)照組,具有統(tǒng)計(jì)學(xué)意義(P0.05)；(3)在霍普金斯語(yǔ)言學(xué)習(xí)(HYLT-R)方面,高危組和健康對(duì)照組得分較高,精神病超高危組、首發(fā)精神分裂癥組和復(fù)發(fā)精神分裂癥組得分較低,有統(tǒng)計(jì)學(xué)意義(p＜0.05)；(4)在簡(jiǎn)易視覺記憶測(cè)驗(yàn)(BVMT-R)方面,健康對(duì)照組得分最高,首發(fā)精神分裂癥組和復(fù)發(fā)精神分裂癥組得分最低,精神病超高危組和高危組介于前兩者之間,具有統(tǒng)計(jì)學(xué)意義(p＜0.05)；(5)在Stroop色詞測(cè)驗(yàn)方面,精神病超高危組成績(jī)好于首發(fā)精神分裂癥組和復(fù)發(fā)精神分裂癥組,但是又比高危組和健康對(duì)照組差,具有統(tǒng)計(jì)學(xué)意義(p＜0.05)；(6)在持續(xù)操作測(cè)驗(yàn)(CPT)方面,精神病超高危組成績(jī)好于首發(fā)精神分裂癥組和復(fù)發(fā)精神分裂癥組,但比高危組和健康對(duì)照組差,具有統(tǒng)計(jì)學(xué)意義(p＜0.05)。結(jié)論：1.精神病超高危人群出現(xiàn)精神病理癥狀,尚未達(dá)到精神病診斷標(biāo)準(zhǔn)。2.精神病超高危人群的家庭親密度和個(gè)人內(nèi)心領(lǐng)悟能力下降。3.精神病超高危人群出現(xiàn)廣泛的認(rèn)知功能受損,涉及信息處理速度、記憶力、注意力等方面。其中信息處理速度異�？赡苁蔷穹至寻Y內(nèi)表型的預(yù)警因素。4.精神分裂癥陽(yáng)性家族史的高危人群的認(rèn)知功能下降,提示可能存在遺傳素質(zhì)因素影響。
[Abstract]:Objective: through mental illness at ultra high risk group, high risk group, first-episode schizophrenia group, compare the recurrence function and psychological status of patients with mental cognitive division, difference analysis of people at ultra high risk of psychosis neurocognitive function and psychological status with other people, to find some endophenotype related psychopathology potential, to achieve sub the clinical features (subclinical trait) or prodromal period (prodromal) early identification, provide the basis for the diagnosis and intervention of mental illness at ultra high risk, improve the prognosis and reduce disability. Methods: 40 cases treated with row and spirit in addition to the standard of schizophrenia in the first-degree relatives of psychiatric ultra high-risk subjects, 40 cases first degree relatives of schizophrenia in high-risk group, 40 cases of patients with first-episode schizophrenia, 40 cases of recurrence in patients with schizophrenia and 40 healthy control group as the research object. All the research objects into the group after the completion of the project : (1) general and psychiatric symptoms: general situation using the self-made demographic data questionnaire; symptom assessment by Montgomery-Asberg Depression Scale (MADRS), positive and negative symptom scale (PANSS). (2) social psychological assessment: the childhood experience questionnaire, family cohesion and adaptability scale and the life events scale, social support scale, Luxemburg self esteem scale, coping style questionnaire and psychological assessment tools. (3) neurocognitive assessment: the connection test (the Trail Making Test Part A, TMTA), the symbol encoding (Symbol coding Test), the Hopki Verbal Learning Test revised (Hopkins Verbal Learning Test-Revised, HVLT-R), simple visual memory test revised (Brief Visuospatial Memory Test-Revised, BVMT-R), Stroop color word test (Stroop Color WordTest, Stroop C-W, continuous performance test (Continuou) S Performance Test, CPT) and other cognitive function test. The main difference between mental illness at ultra high risk group in the cognitive function and psychological status with other groups. Results: 1. symptom comparison: (1) comparison results: depressive symptoms at ultra high risk of psychosis group depression was better than the first onset schizophrenia group and recurrence the schizophrenia group, difference in high risk group and healthy control group, with statistical significance (P0.05); (2) the PANSS scale comparison results: psychotic super high risk group than in schizophrenia group and recurrent schizophrenia group, but high risk group and healthy control group difference was statistically significant (P < 0.05).2. (1): the social psychology of childhood experience questionnaire. The results show that the ultra high risk group mental illness in childhood experience score was significantly lower than the schizophrenia group, recurrent schizophrenia group and healthy control group, the Statistical significance of P0.05), and there is no significant difference between the high risk group (P < 0.05); (2) the family adaptability and cohesion scale results in cohesion scores, psychosis super high risk group, high risk group, schizophrenia group, recurrent schizophrenia group there is no significant difference between the four between the groups (P < 0.05), but the control group was significantly higher than the other groups. The adaptability scores, mental illness at ultra high risk group, healthy control group scored significantly higher than the high-risk group, schizophrenia group and recurrent schizophrenia group, with statistical significance (P0.05); (3) the results of life event scale show that life events scores have no significant difference (P0.05); (4) social support scale. The results showed that mental illness at ultra high risk group, high risk group scored significantly higher than the schizophrenia group and recurrent schizophrenia group scores of health Compared with the highest score, with statistical significance (P < 0.05); (5) the Luxemburg self esteem scale. The results show that the ultra high risk group and the scores of psychiatric health control group scores had no significant difference (P < 0.05), but significantly higher than the high-risk group, schizophrenia group and recurrent schizophrenia group (P0.05); (6) coping style questionnaire. The results show that the rationalization of the five groups had no statistical significance (P0.05), to solve the problem of dimension, mental illness at ultra high risk group, high risk group and healthy control group was significantly higher than that of the recurrence of schizophrenia group score, recurrent schizophrenia group score was significantly higher than that of first division and spirit in the score division; in the era, psychosis super high risk group, high risk group and healthy control group were significantly lower than the schizophrenia group and recurrent schizophrenia group score; in turn, psychosis super high risk group, high risk group and healthy controls Group had significantly lower scores of first-episode schizophrenia group and recurrent schizophrenia group score; in the fantasy, the healthy control group were significantly lower than that of other groups of scores; in the backoff, the healthy control group were significantly lower than the high-risk group, schizophrenia group and recurrent schizophrenia group.3. score comparison results of neurocognitive function: (1) in the connection test (TMTA) aspects of mental illness, ultra high-risk group scored significantly shorter in the schizophrenia group and recurrent schizophrenia group, but higher than the high-risk group and healthy control group in long time, with statistical significance (P0.05); (2) in the symbol encoding, mental disease ultra high risk group were higher than that of schizophrenia group and recurrent schizophrenia group, but lower than the high risk group and healthy control group, with statistical significance (P0.05); (3) study in Hopki language (HYLT-R), high risk group and healthy The control group scored higher, psychosis super high risk group, schizophrenia group and recurrent schizophrenia group lower scores was statistically significant (P < 0.05); (4) in a simple visual memory test (BVMT-R), healthy control group had the highest scores, schizophrenia group and recurrent schizophrenia the lowest score between group, mental illness at ultra high risk group and high risk group between the first two, with statistical significance (P < 0.05); (5) in the Stroop color word test, psychosis super high risk group is better than the schizophrenia group and recurrent schizophrenia group, but also than the high-risk group and healthy controls group difference was statistically significant (P < 0.05); (6) in the continuous performance test (CPT), psychosis super high risk group is better than the schizophrenia group and recurrent schizophrenia group, but higher than the high-risk group and healthy control group difference was statistically significant (P < 0.05). Conclusion: 1. people at ultra high risk of psychosis mental symptoms, psychiatric diagnosis has not yet reached the standard of.2. people at ultra high risk of psychosis family cohesion and inner personal comprehension ability decreased.3. people at ultra high risk of psychosis appear extensive cognitive impairments, information processing speed, memory, attention and cognitive function among high-risk groups. Early warning factors of information processing speed may be abnormal in schizophrenia phenotype.4. schizophrenia positive family history of the decline, indicating the effect of genetic quality factors.

【學(xué)位授予單位】：南方醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2015
【分類號(hào)】：R749.3

【相似文獻(xiàn)】

相關(guān)期刊論文 前10條

1 陳方煜,蔡昌群,萬承龍,武慎彬,陽(yáng)中明,汪開山;利培酮治療20例首發(fā)精神分裂癥的療效分析[J];四川精神衛(wèi)生;2000年03期

2 陳方煜,蔡昌群,萬承龍,武慎彬,陽(yáng)中明,汪開山;利培酮治療首發(fā)精神分裂癥[J];皖南醫(yī)學(xué)院學(xué)報(bào);2000年03期

3 李秀華;在校生首發(fā)精神分裂癥108例臨床分析[J];現(xiàn)代康復(fù);2000年13期

4 陳海支,尹剛,李新勝,劉曉華,徐靜;不同預(yù)后的首發(fā)精神分裂癥患者免疫球蛋白及補(bǔ)體成分的研究[J];中華精神科雜志;2001年02期

5 李獻(xiàn)云,費(fèi)立鵬,張培琰,吉中孚;首發(fā)精神分裂癥病人的抑郁癥狀[J];中國(guó)神經(jīng)精神疾病雜志;2001年02期

6 李菲菲,費(fèi)立鵬,李蘭英,孟梅,閻德亮;首發(fā)精神分裂癥家庭情感表達(dá)特點(diǎn)[J];中國(guó)心理衛(wèi)生雜志;2001年05期

7 王嫻賢,陳平周,洪曉虹,陳曲亮;利培酮對(duì)首發(fā)精神分裂癥療效觀察[J];神經(jīng)疾病與精神衛(wèi)生;2001年04期

8 孫傳賢,孫文儀;首發(fā)精神分裂癥復(fù)發(fā)的原因分析[J];臨床精神醫(yī)學(xué)雜志;2001年06期

9 倪峻華,歐陽(yáng)筠淋;利培酮治療首發(fā)精神分裂癥臨床觀察[J];山東精神醫(yī)學(xué);2001年02期

10 左津淮,尋知元,王茂華,曹毅;利培酮治療首發(fā)精神分裂癥患者的療效分析[J];四川精神衛(wèi)生;2001年03期

相關(guān)會(huì)議論文 前10條

1 秦天星;郭細(xì)先;曾德志;華曙光;;首發(fā)精神分裂癥患者家庭環(huán)境對(duì)其復(fù)發(fā)的影響[A];2009年浙江省醫(yī)學(xué)會(huì)精神病學(xué)學(xué)術(shù)年會(huì)暨浙江省醫(yī)師協(xié)會(huì)精神科醫(yī)師分會(huì)第二屆年會(huì)論文匯編[C];2009年

2 湯慶平;朱培俊;賴根祥;張靜;;阿立哌唑和利培酮治療首發(fā)精神分裂癥的對(duì)照[A];2009年浙江省醫(yī)學(xué)會(huì)精神病學(xué)學(xué)術(shù)年會(huì)暨浙江省醫(yī)師協(xié)會(huì)精神科醫(yī)師分會(huì)第二屆年會(huì)論文匯編[C];2009年

3 施劍飛;沈鑒清;;阿立派唑與利培酮治療門診首發(fā)精神分裂癥的臨床研究[A];2006年浙江省精神病學(xué)學(xué)術(shù)會(huì)議論文匯編[C];2006年

4 陳梅芳;;阿立派唑與利培酮治療首發(fā)精神分裂癥的對(duì)照研究[A];2006年浙江省精神病學(xué)學(xué)術(shù)會(huì)議論文匯編[C];2006年

5 張君青;羅忠;周斌斌;;首發(fā)精神分裂癥患者親屬的心理健康狀況分析[A];2006年浙江省精神病學(xué)學(xué)術(shù)會(huì)議論文匯編[C];2006年

6 陳銘;張?jiān)伱?;阿立哌唑治療首發(fā)精神分裂癥臨床觀察[A];中華醫(yī)學(xué)會(huì)精神病學(xué)分會(huì)第七屆學(xué)術(shù)年會(huì)論文摘要集[C];2006年

7 黃繼偉;張生;彭海艮;陸先臻;;阿立哌唑與利培酮治療首發(fā)精神分裂癥對(duì)照研究[A];中華醫(yī)學(xué)會(huì)精神病學(xué)分會(huì)第七屆學(xué)術(shù)年會(huì)論文摘要集[C];2006年

8 魯從林;吳華玲;周忠蓮;張峰;金俊;楊勇;;阿立哌唑治療首發(fā)精神分裂癥臨床觀察[A];中華醫(yī)學(xué)會(huì)精神病學(xué)分會(huì)第七屆學(xué)術(shù)年會(huì)論文摘要集[C];2006年

9 郭琴;潘苗;張凌芳;;綜合干預(yù)對(duì)首發(fā)精神分裂癥患者預(yù)后的影響[A];2007河南省精神衛(wèi)生學(xué)術(shù)研討會(huì)資料匯編[C];2007年

10 龐禮娟;宋學(xué)勤;呂路線;趙靖平;李幼輝;李雪;高金松;;在校學(xué)生首發(fā)精神分裂癥患者臨床特征及療效分析[A];中華醫(yī)學(xué)會(huì)精神病學(xué)分會(huì)第九次全國(guó)學(xué)術(shù)會(huì)議論文集[C];2011年

相關(guān)重要報(bào)紙文章 前2條

1 薛原;三成非首發(fā)精神分裂癥患者存在服藥依從性問題[N];健康報(bào);2007年

2 ;氯氮平和利培酮對(duì)首發(fā)精神分裂癥患者糖代謝影響的研究[N];中國(guó)醫(yī)藥報(bào);2003年

相關(guān)博士學(xué)位論文 前3條

1 陶好娟;首發(fā)精神分裂癥患者腦灰質(zhì)和腦網(wǎng)絡(luò)的磁共振成像研究[D];中南大學(xué);2012年

2 劉登堂;首發(fā)精神分裂癥患者的認(rèn)知功能及功能磁共振成像研究[D];復(fù)旦大學(xué);2003年

3 張會(huì)然;首發(fā)精神分裂癥患者不同癥狀維度多模態(tài)磁共振成像研究[D];中南大學(xué);2013年

相關(guān)碩士學(xué)位論文 前10條

1 李國(guó)華;膠質(zhì)纖維酸性蛋白及基因多態(tài)性與首發(fā)精神分裂癥的相關(guān)性研究[D];昆明醫(yī)科大學(xué);2013年

2 黑鋼瑞;首發(fā)精神分裂癥患者腸道菌群與炎性因子的相互作用研究[D];鄭州大學(xué);2015年

3 祁繼鵬;首發(fā)精神分裂癥及超高危人群的認(rèn)知功能對(duì)照研究[D];新鄉(xiāng)醫(yī)學(xué)院;2015年

4 陳領(lǐng);共情能力對(duì)首發(fā)精神分裂癥患者自知力的影響[D];安徽醫(yī)科大學(xué);2015年

5 石賀敏;首發(fā)精神分裂癥患者隨訪1年復(fù)發(fā)規(guī)律及相關(guān)因素分析[D];華北理工大學(xué);2015年

6 王中磊;精神病超高危人群認(rèn)知功能和心理狀況的比較研究[D];南方醫(yī)科大學(xué);2015年

7 方今女;首發(fā)精神分裂癥的五年隨訪結(jié)構(gòu)[D];延邊大學(xué);2005年

8 李惠芳;家庭社會(huì)經(jīng)濟(jì)情況教養(yǎng)方式家庭環(huán)境與首發(fā)精神分裂癥的相關(guān)研究[D];蘭州大學(xué);2007年

9 萬靜;首發(fā)精神分裂癥患者血清細(xì)胞因子濃度與臨床癥狀相關(guān)性研究[D];昆明醫(yī)學(xué)院;2010年

10 胡茂榮;首發(fā)精神分裂癥患者及其健康同胞認(rèn)知功能的研究[D];中南大學(xué);2009年

，

本文編號(hào)：1420450