研究背景及目的慢加急性肝衰竭（ACLF）是一種以慢性肝病急性失代償和高短期死亡率為特征的臨床綜合征。因?yàn)锳CLF的存活率極低（28天死亡率:22%-77%）,根據(jù)預(yù)后對(duì)患者進(jìn)行分層是至關(guān)重要的,以確定肝移植（LT）的緊迫性。雖然終末期肝病模型（MELD）是評(píng)估ACLF患者最廣泛使用的方法,但它缺乏臨床事件的指標(biāo),如腹水、低鈉血癥、肝腎綜合征和其他并發(fā)癥。隨著近年來(lái)肝病新療法的不斷涌現(xiàn),迫切需要開(kāi)發(fā)新的指標(biāo),完善評(píng)價(jià)ACLF患者病情嚴(yán)重程度和預(yù)后的指標(biāo)體系。紅細(xì)胞分布寬度（RDW）是反映紅細(xì)胞體積異質(zhì)性程度的一個(gè)簡(jiǎn)單而廉價(jià)的參數(shù),傳統(tǒng)上用于實(shí)驗(yàn)室血液學(xué)鑒別診斷貧血。最近,RDW作為各種疾病如膿毒癥、急性心肌梗死、心力衰竭、自身免疫性疾病和肝病的預(yù)后標(biāo)志物而受到廣泛關(guān)注。近年來(lái),外周血中性粒細(xì)胞與淋巴細(xì)胞比值（NLR）作為全身炎癥標(biāo)志物的研究越來(lái)越多,特別是考慮到其通過(guò)常規(guī)血細(xì)胞計(jì)數(shù)快速、廣泛和相對(duì)便宜的評(píng)估。NLR已被證明是各種實(shí)體腫瘤的獨(dú)立預(yù)后因子,包括肺癌、結(jié)直腸癌、胰腺癌、乳腺癌、卵巢癌和胃癌。但是目前關(guān)于NLR、RDW聯(lián)合MELD評(píng)分對(duì)ACLF預(yù)后的評(píng)估價(jià)值的研究較少,本文通過(guò)回... 

【文章頁(yè)數(shù)】：65 頁(yè)

【學(xué)位級(jí)別】：碩士

【文章目錄】：
摘要
Abstract
主要英文縮略詞表
引言
材料與方法
結(jié)果
討論
結(jié)論
參考文獻(xiàn)
綜述 慢加急性肝功能衰竭的研究進(jìn)展
    參考文獻(xiàn)
個(gè)人簡(jiǎn)歷及在校期間發(fā)表論文
致謝


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