BACKGROUND: Acute liver failure（ALF） is a severe and lifethreatening clinical syndrome resulting in a high mortality and extremely poor prognosis. Recently, a water-soluble CO-releasing molecule（CORM-3） has been shown to have anti-inflammatory effect. The present study was to investigate the effect of CORM-3 on ALF and elucidate its underlying mechanism.METHODS: ALF was induced by a combination of LPS/D-Gal N in mice which were treated with CORM-3 or inactive CORM-3（i CORM-3）. The efficacy of CO... 

【文章來(lái)源】：Hepatobiliary & Pancreatic Diseases International. 2016,15(01)SCICSCD

【文章頁(yè)數(shù)】：8 頁(yè)

【文章目錄】：
Introduction
Methods
    Animals
    Reagents
    Experimental groups
    Measurement of serum aminotransferase activities and TBi L
    Histology
    Cytokine assays
    Immunohistochemistry
    COX-2, i NOS and TLR4 determination by Western blotting
    Statistical analysis
Results
    Effects of CORM-3 on the mortality of LPS/D-Gal Ntreated mice
    Effects of CORM-3 on serum levels of aminotransferase and TBi L in mice with ALF
    Histopathological analysis
    Effects of CORM-3 on cytokines production induced by LPS/D-Gal N
    Effects of CORM-3 on the expression of NF-κB-p65in the liver after LPS/D-Gal N injection
    Effects of CORM-3 on the expression of COX-2, i NOS and TLR4 proteins after the injection of LPS/D-Gal N
Discussion



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