【摘要】：目的觀察基質(zhì)金屬蛋白酶-9(MMP-9)與急性ST段抬高心肌梗死(STEMI)接受經(jīng)皮冠狀動(dòng)脈介入(PCI)治療并置入藥物涂層支架的患者近期支架內(nèi)再狹窄(ISR)的關(guān)系。方法選擇2010年3月至2013年3月在該院接受介入治療的STEMI患者210例為觀察對(duì)象,按照是否發(fā)生ISR,分為ISR組33例與無ISR組177例,測量并比較兩組外彈力膜橫截面面積、斑塊面積、最小管腔面積及內(nèi)膜增生面積;術(shù)前及隨訪時(shí)均檢測MMP-9水平。結(jié)果 ISR組患者M(jìn)MP-9水平在隨訪節(jié)點(diǎn)明顯高于非ISR組,ROC曲線分析發(fā)現(xiàn),以MMP-9≥2.425ng/mL為診斷分界值預(yù)測ISR的發(fā)生,其曲線下面積(AUC)為0.834(95%CI:0.745~0.923),敏感度0.697,特異性0.915,約登指數(shù)0.612,具有較好的診斷價(jià)值。MMP-9升高的患者外彈力膜橫截面積、內(nèi)膜增生面積及斑塊面積大于不升高患者,而最小管腔面積低于不升高患者,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論 PCI術(shù)后ISR患者M(jìn)MP-9水平較術(shù)前升高,監(jiān)測MMP-9水平對(duì)PCI術(shù)后ISR有一定的預(yù)測作用。
[Abstract]:Objective to investigate the relationship between matrix metalloproteinase-9 (MMP-9) and in-stent restenosis (ISR) in patients with acute ST segment elevation myocardial infarction (STEMI) treated with percutaneous coronary intervention (PCI) and implanted with drug-coated stents. Methods from March 2010 to March 2013, 210 patients with STEMI were divided into ISR group (n = 33) and non-ISR group (n = 177). The cross-sectional area of external elastic membrane and plaque area were measured and compared between the two groups. Minimum lumen area and intimal hyperplasia area; The levels of MMP-9 were measured before and after follow-up. Results the level of MMP-9 in ISR group was significantly higher than that in non-ISR group. ROC curve analysis showed that MMP-9 鈮，

本文編號(hào)：2451202