發(fā)布時(shí)間：2018-11-08 06:52

【摘要】：目的：觀察維吾爾族和漢族急性心肌梗死患者經(jīng)皮冠狀動(dòng)脈介入治療后血漿N末端腦鈉肽前體（NT-proBNP）動(dòng)態(tài)變化趨勢(shì)特點(diǎn)，分析該評(píng)價(jià)指標(biāo)與左室功能（LVEF）、同型半胱氨酸（HCY）的關(guān)系，進(jìn)一步探討NT-proBNP在維、漢兩組之間是否有民族差異及NT-proBNP的預(yù)后評(píng)估意義，，最終嘗試選定維吾爾族和漢族作為預(yù)后評(píng)估指標(biāo)時(shí)的檢測(cè)時(shí)間截點(diǎn)。方法：納入2011年3月至2012年2月之間我院心臟中心行急診PCI治療的AMI患者128例，根據(jù)族別分為漢族組（n=78）和維吾爾族組(n=50)，記錄罪犯血管情況，分別完善同型半胱氨酸檢測(cè)，術(shù)前、術(shù)后14~48h、術(shù)后49~72h的連續(xù)NT-proBNP快速床旁檢測(cè)，術(shù)后6個(gè)月隨訪心臟LVEF值。所有數(shù)據(jù)均采用SPSS17.0統(tǒng)計(jì)軟件進(jìn)行統(tǒng)計(jì)分析。結(jié)果：維漢兩民族的NT-proBNP變化趨勢(shì)存在各自的特點(diǎn)，維吾爾族的平均NT-proBNP水平較漢族患者低（P0.05）；PCI前后不同時(shí)間段NT-proBNP的差異有顯著統(tǒng)計(jì)學(xué)意義（F=56.316，P0.05）。維漢兩民族不同罪犯血管NT-proBNP水平亦有差異；漢族組6個(gè)月時(shí)LVEF值與術(shù)后14~48h段的NT-proBNP值相關(guān)性最好，呈負(fù)相關(guān)(r=-0.7），而維族組LVEF與三個(gè)時(shí)間段的NT-proBNP值相關(guān)性基本一致，呈負(fù)相關(guān)（r=-0.8）。結(jié)論：NT-proBNP的分泌水平具有一定的民族差異，漢族PCI患者的預(yù)后評(píng)估的最佳時(shí)間截點(diǎn)建議為14~48h，維族患者49~72h的NT-proBNP值可較準(zhǔn)確的評(píng)估。
[Abstract]:Objective: to observe the trend of plasma N-terminal brain natriuretic peptide precursor (NT-proBNP) in patients with acute myocardial infarction (AMI) in Uygur and Han nationality after percutaneous coronary intervention (PCI). The relationship between homocysteine (HCY) (Hcy (HCY) and the prognostic significance of NT-proBNP in Uygur and Han groups, and the prognostic value of NT-proBNP. Finally, we try to select Uygur and Han as prognostic indicators. Methods: from March 2011 to February 2012, 128 patients with AMI received emergency PCI treatment in our heart center were divided into two groups: Han nationality group (n = 78) and Uygur group (n = 50). The blood vessels of the criminals were recorded. Homocysteine was detected by continuous NT-proBNP fast bedside test before operation, at 1448 hours after operation and 4972 hours after operation. The cardiac LVEF values were followed up 6 months after operation. All the data were analyzed by SPSS17.0 software. Results: the variation trend of NT-proBNP in Uygur and Han nationalities had their own characteristics. The average NT-proBNP level of Uygur was lower than that of Han (P0.05). The difference of NT-proBNP before and after PCI was statistically significant (P 0.05). The levels of vascular NT-proBNP of different criminals in Uygur and Han nationalities were also different. The correlation between LVEF and NT-proBNP at 144h postoperatively was the best in Han group at 6 months (r = -0.7), but the correlation between LVEF and NT-proBNP in Uygur group was almost the same (r ~ (-0.8). Conclusion: the secretory level of NT-proBNP is different in different nationalities. The best time for prognosis evaluation of PCI patients in Han nationality is 144h. The NT-proBNP value of 4972h in Uygur nationality patients can be accurately evaluated.
【學(xué)位授予單位】：新疆醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2013
【分類號(hào)】：R542.22

【參考文獻(xiàn)】

相關(guān)期刊論文 前6條

1 危小軍;劉芳;廖偉;鐘一鳴;謝東明;王小萍;廖祥中;謝東陽;;經(jīng)皮冠狀動(dòng)脈介入治療老年急性心肌梗死最佳時(shí)間窗的臨床研究[J];中華老年心腦血管病雜志;2007年04期

2 劉向陽;唐良秋;江志平;張社兵;肖雨雄;何鳳屏;李愛華;萬槐斌;范文茂;陳寶峰;;氨基末端腦鈉肽前體對(duì)急性心肌梗死患者的預(yù)后評(píng)價(jià)[J];中國(guó)循證心血管醫(yī)學(xué)雜志;2012年02期

3 朱慧萍,趙如冰,刀京晶,李竹,金麗,高謙;中國(guó)北方少數(shù)民族人群同型半胱氨酸代謝酶的遺傳多態(tài)性[J];中國(guó)優(yōu)生優(yōu)育;2000年02期

4 顧國(guó)嶸;欒驍;姚晨玲;鄧至;童朝陽;;氨基端前腦鈉肽對(duì)急性心肌梗死患者院內(nèi)預(yù)后的判斷價(jià)值[J];中華臨床醫(yī)師雜志(電子版);2011年16期

5 郭明;張宗輝;楊杰;;不同時(shí)間窗冠狀動(dòng)脈介入治療對(duì)急性心肌梗死患者血漿N-末端利鈉肽前體水平的影響[J];中華危重癥醫(yī)學(xué)雜志(電子版);2011年02期

6 葉彬華;李祖輝;張蓉艷;;平板運(yùn)動(dòng)試驗(yàn)ST壓低幅度與血漿C反應(yīng)蛋白和N末端腦利鈉肽前體的關(guān)系[J];中國(guó)鄉(xiāng)村醫(yī)藥;2012年16期

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