【摘要】：目的探討左西孟旦對急性有機(jī)磷農(nóng)藥中毒(AOPP)所致心功能不全患者心功能的影響。方法選取AOPP所致心功能不全的患者51例,隨機(jī)分為對照組26例、治療組25例。兩組均給予內(nèi)科常規(guī)聯(lián)合血液灌流(HP)及連續(xù)性靜脈-靜脈血液濾過(CVVH)的基礎(chǔ)治療,對照組采用微量泵持續(xù)泵入多巴酚丁胺,治療組采用微量泵持續(xù)泵入左西孟旦注射液。治療前及治療后12、24、48 h行超聲心動圖檢查,測算左心室射血分?jǐn)?shù)(LVEF)、左心室舒張末期內(nèi)徑(LVIDd),抽取外周靜脈血檢測血漿B型腦鈉肽(BNP)水平。記錄兩組28 d死亡例數(shù)、機(jī)械通氣應(yīng)用時間,計(jì)算病死率。結(jié)果與治療前比較,兩組治療后各時間點(diǎn)LVEF均增大,LVIDd及BNP均降低(P均0.05)。與對照組比較,治療組治療后各時間點(diǎn)LVEF均增大,LVIDd及BNP均降低(P均0.05)。兩組治療后各時點(diǎn)血漿BNP水平均低于治療前,治療組治療12、24、48 h時血漿BNP水平均低于對照組(P均0.05)。治療組治療28 d時病死率低于對照組(P0.05),應(yīng)用機(jī)械通氣時間少于對照組(P0.05)。結(jié)論左西孟旦能夠明顯改善AOPP所致心功能不全患者的心功能,并可降低病死率、縮短機(jī)械通氣治療時間。
[Abstract]:Objective to investigate the effect of levosimendan on cardiac function in patients with cardiac insufficiency caused by acute organophosphorus pesticide poisoning (AOPP). Methods 51 patients with cardiac dysfunction caused by AOPP were randomly divided into control group (n = 26) and treatment group (n = 25). Both groups were treated with routine internal medicine combined with hemoperfusion of (HP) and continuous veno-venous hemofiltration (CVVH). The control group was continuously pumped into dobutamine by micropump, while the treatment group was treated with micropump continuous pump into levosimendan injection. The left ventricular ejection fraction (LVEF),) and left ventricular end-diastolic diameter (LVIDd),) were measured by echocardiography before treatment and 48 hours after treatment. Peripheral venous blood was extracted to detect the level of B-type brain natriuretic peptide (BNP) (BNP) in plasma. The death cases of 28 days, the duration of mechanical ventilation and the mortality of the two groups were recorded. Results compared with before treatment, LVEF increased, LVIDd and BNP decreased at each time point after treatment in both groups (P0. 05). Compared with the control group, the LVEF increased and the LVIDd and BNP decreased at each time point after treatment in the treatment group. Plasma BNP levels in both groups were lower than those before treatment at all time points after treatment. Plasma BNP levels in the treatment group were lower than those in the control group at 48 h after treatment (P < 0. 05). The fatality rate of the treatment group was lower than that of the control group at 28 days (P0.05), and the time of mechanical ventilation was less than that of the control group (P0.05). Conclusion Levomycin can significantly improve the cardiac function of patients with cardiac insufficiency caused by AOPP, reduce the mortality and shorten the time of mechanical ventilation.
【作者單位】： 單縣中心醫(yī)院;
【分類號】：R595.4

【相似文獻(xiàn)】

相關(guān)期刊論文 前10條

1 趙艷紅;;糖尿病患者心功能改變探討[J];中國社區(qū)醫(yī)師(醫(yī)學(xué)專業(yè)半月刊);2008年16期

2 昝俊平，伊昭云，孫興斌，南文考，馬智;海拔3700m高原移居人體心功能適應(yīng)指數(shù)的變化[J];高原醫(yī)學(xué)雜志;1995年01期

3 石凱，王登高，，王勇，張彥文，莫非凡;模擬高原與高原現(xiàn)場體能及心功能對比探討[J];職業(yè)衛(wèi)生與病傷;1995年03期

4 李全會,杜鳳蘭,孟憲法;進(jìn)入高原后心功能出現(xiàn)改變的追蹤觀察[J];心功能雜志;1996年03期

5 肖桂蓉,李雪冰,段成風(fēng);老年心電圖與心功能探討[J];中國療養(yǎng)醫(yī)學(xué);1999年01期

6 何風(fēng)云;老年甲狀腺功能減退癥26例臨床分析[J];現(xiàn)代中西醫(yī)結(jié)合雜志;2003年19期

7 鄭艷華;周麗;李智慧;;倍他樂克致急性心功能衰竭一例[J];中華急診醫(yī)學(xué)雜志;2006年09期

8 吳常達(dá);;老年類風(fēng)濕關(guān)節(jié)炎患者心功能變化臨床分析[J];現(xiàn)代實(shí)用醫(yī)學(xué);2012年05期

9 劉健;曹云祥;朱艷;;老年類風(fēng)濕關(guān)節(jié)炎患者心功能變化及其相關(guān)性研究[J];中華中醫(yī)藥雜志;2011年04期

10 齊亞軍;劉健;曹云祥;孫s

本文編號：2280512