【摘要】：目的探討血漿氧化三甲胺(TMAO)水平與急性心肌梗死(AMI)患者住院期間并發(fā)癥之間的關(guān)系。方法入選2014年1月至2015年12月入住我院AMI患者200例,根據(jù)住院期間有無發(fā)生并發(fā)癥(新發(fā)癥狀性心力衰竭、心律失常、心源性休克)分為單純心肌梗死組(n=42)和心肌梗死并發(fā)癥組(n=158);根據(jù)入院時(shí)TMAO水平四分位分為4組,每組50例。比較各組的臨床資料。應(yīng)用Logistic回歸計(jì)算不同TMAO水平并發(fā)癥發(fā)生風(fēng)險(xiǎn)的比值比。Spearman秩相關(guān)分析比較TMAO與心肌肌鈣蛋白Ⅰ(cTnⅠ)、N末端腦鈉肽前體(NT-proBNP)和高敏C反應(yīng)蛋白(hs-CRP)的相關(guān)性。結(jié)果心肌梗死并發(fā)癥組TMAO水平顯著高于單純心肌梗死組(6.4±1.8μmol/L比4.2±1.3μmol/L,P0.05)。AMI患者TMAO水平與并發(fā)癥發(fā)生風(fēng)險(xiǎn)之間存在正相關(guān),校正年齡、糖尿病、估算腎小球?yàn)V過率、左心室舒張末期內(nèi)徑、左心室射血分?jǐn)?shù)、NT-proBNP、cTnⅠ和hs-CRP以后,TMAO水平最高四分位數(shù)患者發(fā)生并發(fā)癥的風(fēng)險(xiǎn)是最低四分位數(shù)患者的6.01倍(95%CI 2.03~17.73,P0.05)。TMAO與cTnⅠ、NT-proBNP和hsCRP的相關(guān)性強(qiáng)弱順序?yàn)?cTnⅠ、NT-proBNP、hs-CRP(秩相關(guān)系數(shù)分別為0.72、0.64、0.42,均P0.05)。結(jié)論血漿TMAO水平與AMI患者住院期間并發(fā)癥風(fēng)險(xiǎn)及血漿cTnⅠ、NT-proBNP、hs-CRP水平密切相關(guān)。
[Abstract]:Objective to investigate the relationship between plasma trimethylamine oxide (TMAO) levels and in-hospital complications in patients with acute myocardial infarction (AMI). Methods 200 patients with AMI admitted to our hospital from January 2014 to December 2015 were enrolled. According to the complications (new symptomatic heart failure, arrhythmia), Cardiogenic shock was divided into two groups: myocardial infarction group (n = 42) and myocardial infarction complication group (n = 158). According to the quartile of TMAO at admission, they were divided into 4 groups with 50 cases in each group. The clinical data of each group were compared. Logistic regression was used to calculate the ratio of complications at different TMAO levels. Spearman rank correlation analysis was used to compare the correlation between TMAO and cardiac troponin 鈪，

本文編號(hào)：2225325