【摘要】：目的探究膿毒癥患者N-末端B型利鈉肽(NT-pro BNP)以及脈搏指數(shù)連續(xù)心排血量(Pi COO)監(jiān)測(cè)指標(biāo)與預(yù)后的相關(guān)性。方法選擇膿毒癥患者113例。經(jīng)過(guò)1個(gè)月的治療74例存活,39例死亡。對(duì)比存活組與死亡組患者臨床資料以及不同階段NT-pro BNP水平、治療前的Pi CCO各指標(biāo),最后進(jìn)行相關(guān)性分析。結(jié)果存活組APACHEⅡ評(píng)分顯著低于死亡組,并且出現(xiàn)嚴(yán)重感染以及并發(fā)癥的患者比例也顯著低于死亡組;兩組在第1天NT-pro BNP水平比較無(wú)差異,存活組在第3、5、7天NT-pro BNP水平均顯著低于死亡組;兩組胸腔內(nèi)血容量指數(shù)(ITBVI)、體外循環(huán)阻力指數(shù)(SVRI)無(wú)顯著差異,但存活組心臟指數(shù)(CI)高于死亡組,而血管外肺水指數(shù)(EVLWI)、肺毛細(xì)血管通透性指數(shù)(PVPI)低于死亡組(均P0.05)。通過(guò)相關(guān)性分析得到:NT-pro BNP、EVLWI、PVPI與死亡率存在明顯正相關(guān)(r=0.741,P=0.000;r=0.731,P=0.000;r=0.814,P=0.000),CI與死亡率存在明顯負(fù)相關(guān)(r=-0.261,P=0.000)。結(jié)論膿毒癥患者血漿中NT-pro BNP水平隨著病情加重而逐漸升高,結(jié)合APACHEⅡ評(píng)分兩者越高預(yù)后越差。Pi COO監(jiān)測(cè)指標(biāo)也與預(yù)后存在顯著相關(guān)性,對(duì)臨床治療及預(yù)后評(píng)估具有非常高的指導(dǎo)價(jià)值。
[Abstract]:Objective to investigate the relationship between the prognostic value of N-terminal B-type natriuretic peptide (NT-pro BNP) and continuous cardiac output (Pi COO) of pulse index in patients with sepsis. Methods 113 patients with sepsis were selected. After 1 month treatment, 74 patients survived and 39 died. The clinical data and NT-pro BNP levels in different stages of survival group and death group were compared, and the indexes of Pi CCO before treatment were analyzed. Results the score of APACHE 鈪，

本文編號(hào)：2183206