【摘要】：目的 研究急性腦出血患者血腫擴大與血清TC，LDL-C水平的關(guān)系。 方法 1、根據(jù)入選標準和排除標準，納入2010年12月～2013年01月在我院急診科就診并收入神經(jīng)內(nèi)科病房住院的腦出血患者共144例； 2、對病例組與對照組所有研究對象進行一般資料統(tǒng)計； 3、所有患者入院后即刻手動血壓計人工測量血壓，進行NIHSS評分，選擇評分1～20分患者作為研究對象； 4、所有患者入院后6h內(nèi)均經(jīng)頭顱CT證實為幕上出血（包括殼核、腦葉、丘腦出血），并于入院后24h復(fù)查頭顱CT，按照多田公式測量并計算血腫體積，以第二次CT血腫量比第一次增加33%定義為血腫擴大，其中血腫擴大組72例，男51例，女21例；對照組72例，男52例，女20例。 5、所有血腫擴大組及對照組均在發(fā)病6h內(nèi)生化試管抽取靜脈血5ml，送本院檢驗中心，由全自動生化分析儀利用GOD法檢測GLU，CHOD-PAP法檢測TC數(shù)值，SUR法檢測LDL-C數(shù)值； 6、對2組臨床資料進行比較，對血腫擴大的影響因素進行統(tǒng)計學(xué)分析。 結(jié)果 1、2組的性別分布、出血部位組成無差異（P＞0.05）； 2、2組NIHSS評分、初始出血量數(shù)值無差異（P＞0.05）； 3、血腫擴大組年齡：62.74±10.14歲，SBP：177.06±25.31mmHg，DBP：103.83±14.52mmHg，GLU：8.06±4.94mmol/L，明顯高于對照組（P0.05）； 4、血腫擴大組TC：3.78±0.62mmol/L，LDL-C：2.10±0.47mmol/L，明顯低于對照組（P0.05）。 5、Logistic回歸模型分析篩選出的變量為：LDL-C(OR=0.001,95%CI:0.001-0.024,p0.001)，，TC(OR=0.057,95%CI:0.004-0.863,p=0.0322)，GLU(OR=1.851,95%CI:1.219-2.810,p=0.0038)，SBP(OR=1.120,95%CI:1.021-1.229,p=0.0165)，DBP(OR=1.152,95%CI:1.052-1.262,p=0.0023)。 結(jié)論 急性腦出血的血腫擴大影響因素包括TC，LDL-C，GLU，SBP和DBP，其中，LDL-C及TC影響最大，故ICH血腫擴大與血清LDL-C，TC水平呈負關(guān)系。
[Abstract]:Objective to study the relationship between hematoma enlargement and serum TCU LDL-C level in patients with acute intracerebral hemorrhage. Methods 1. According to the inclusion criteria and exclusion criteria, 144 patients with intracerebral hemorrhage were enrolled in the emergency department of our hospital from December 2010 to January 2013 and admitted to the department of neurology. 2, the general data of all the subjects in the case group and the control group were statistically analyzed. 3, all the patients were manually measured their blood pressure by manual sphygmomanometer immediately after admission to hospital, and their NIHSS scores were scored. Patients with 1-20 scores were selected as the study subjects. 4, all patients were confirmed as supratentorial hemorrhage (including putamen nucleus, lobes of brain) by cranial CT within 6 hours after admission. Thalamic hemorrhage), and at 24 hours after admission, the volume of hematoma was measured and calculated according to Duotian formula. The hematoma enlargement was defined as hematoma enlargement by 33% in the second CT group, including 72 cases in the hematoma enlargement group, 51 cases in the male and 21 cases in the female. There were 72 cases in control group, 52 cases in male and 20 cases in female. All hematoma enlargement group and control group were collected 5 ml of venous blood in biochemical tube within 6 hours after the onset of the disease, and sent to the laboratory center of our hospital. GOD method was used to detect GLU CHOD-PAP method to detect TC value and sur method to detect LDL-C value. 6, two groups of clinical data were compared, and the influencing factors of hematoma enlargement were analyzed statistically. Results (1) there was no significant difference in sex distribution and bleeding site composition between the two groups (P > 0. 05), but there was no difference in NIHSS score and initial bleeding volume between the two groups (P > 0. 05). 3,琛

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