本文選題：急性大面積腦梗死 + 大株紅景天注射液��； 參考：《中國藥房》2017年32期

【摘要】：目的:考察大株紅景天注射液聯(lián)合長春西汀注射液對急性大面積腦梗死患者的臨床療效、血液流變學指標及血清一氧化氮合酶(NOS)的影響。方法:選取2014年1月-2016年6月我院收治的大面積腦梗死患者60例作為研究對象。按照隨機數(shù)字表法將患者分為對照組和試驗組,各30例。對照組患者給予胞二磷膽堿注射液0.5 g,ivgtt,qd;試驗組在此基礎上給予長春西汀注射液20 mg加至0.9%氯化鈉注射液250 m L中,ivgtt,qd;間隔1 h后沖管,給予大株紅景天注射液10 m L加至0.9%氯化鈉注射液250 m L中,ivgtt,qd,連續(xù)給藥14 d。觀察兩組患者的臨床療效和安全性,以及治療前后血液流變學指標和NOS水平。結(jié)果:試驗組患者臨床總有效率(83.33%)顯著高于對照組(50.00%),差異有統(tǒng)計學意義(P0.05)。治療前,兩組患者血液流變學指標及血清NOS水平比較,差異均無統(tǒng)計學意義(P0.05)。治療后,兩組患者血液流變學指標均顯著降低,且試驗組顯著低于對照組;兩組患者的血清NOS水平均顯著增加,且試驗組顯著高于對照組,差異均有統(tǒng)計學意義(P0.05)。兩組患者均未見明顯的不良反應發(fā)生。結(jié)論:大株紅景天注射液聯(lián)合長春西汀注射液治療急性大面積腦梗死的療效顯著,可減輕血液黏度,增加血流灌注,且安全性較高。
[Abstract]:Objective: to investigate the clinical efficacy, hemorheological parameters and serum nitric oxide synthase (NOS) in patients with acute large area cerebral infarction treated with RDJI combined with vinpocetine injection. Methods: from January 2014 to June 2016, 60 patients with massive cerebral infarction were selected. The patients were divided into control group and experimental group with 30 cases each. The patients in the control group were given citicoline injection 0.5 g / iv QD, the experimental group was treated with vinpocetine injection 20 mg / L to 0.9% sodium chloride injection 250 mL iv gttttqd, and the tube was flushed after 1 hour interval, and the control group was treated with vinpocetine injection (20 mg / ml) and 0.9% sodium chloride injection (250 mL / ml). Large strain Rhodiola injection (10 mL) was added to 0.9% sodium chloride injection (250 mL) for 14 days. The clinical efficacy and safety, hemorheological index and NOS level before and after treatment were observed. Results: the total effective rate in the trial group (83.33%) was significantly higher than that in the control group (50.00%), the difference was statistically significant (P0.05). Before treatment, there was no significant difference in hemorheological indexes and serum NOS levels between the two groups (P0.05). After treatment, the hemorheological indexes of the two groups were significantly decreased, and the experimental group was significantly lower than the control group; the serum NOS levels of the two groups were significantly increased, and the experimental group was significantly higher than the control group, the difference was statistically significant (P0.05). No significant adverse reactions occurred in both groups. Conclusion: large strain Rhodiola injection combined with vinpocetine injection is effective in the treatment of acute large area cerebral infarction, which can reduce blood viscosity and increase blood perfusion.
【作者單位】： 河北北方醫(yī)學院附屬第一醫(yī)院神經(jīng)外科;河北北方醫(yī)學院附屬第一醫(yī)院藥學部;
【基金】：張家口市科學技術(shù)與發(fā)展計劃自籌經(jīng)費項目(No.1421120D)
【分類號】：R743.33

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