本文選題：內(nèi)皮微粒 + 可溶性細(xì)胞間粘附分子-�。� 參考：《西安交通大學(xué)學(xué)報(醫(yī)學(xué)版)》2016年03期

【摘要】：目的研究急性心肌梗死(AMI)患者內(nèi)皮炎癥與無復(fù)流及冠脈病變嚴(yán)重程度的相關(guān)性。方法入選行經(jīng)皮冠狀動脈介入(PCI)治療的AMI患者120例,其中術(shù)中出現(xiàn)無復(fù)流的患者40例為病例組,未出現(xiàn)無復(fù)流的AMI患者80例作為對照組。無復(fù)流組又根據(jù)冠狀動脈造影結(jié)果分為單支病變組14例、兩支病變組10例和三支病變組16例。分別采用流式細(xì)胞術(shù)和ELISA方法對上述患者術(shù)后即刻循環(huán)血內(nèi)皮微粒(EMPs)及可溶性細(xì)胞間粘附分子-1(sICAM-1)水平進行測定。結(jié)果病例組PCI術(shù)后即刻循環(huán)血EMPs及sICAM-1水平均高于對照組,差異具有統(tǒng)計學(xué)意義。病例組EMPs和sICAM-1曲線下面積分別為0.755和0.701,表明EMPs和sICAM-1水平與AMI患者PCI術(shù)后發(fā)生無復(fù)流具有良好的相關(guān)性。冠脈病變Gensini積分和EMPs隨病變支數(shù)的增加呈上升趨勢,且EMPs水平與Gensini積分呈正相關(guān)。結(jié)論 AMI患者循環(huán)血EMPs及sICAM-1水平能夠較好地預(yù)測無復(fù)流的發(fā)生,并對冠脈病變的嚴(yán)重程度也有較好的預(yù)測價值。
[Abstract]:Objective to study the relationship between endothelial inflammation and severity of coronary artery disease in patients with acute myocardial infarction (AMI). Methods 120 patients with AMI underwent percutaneous coronary intervention (PCI). 40 patients with no reflow during operation were selected as the case group and 80 patients with AMI without reflow as the control group. According to the results of coronary angiography, no reflow group was divided into single vessel lesion group (n = 14), two-vessel lesion group (n = 10) and three-vessel lesion group (n = 16). The levels of circulating endothelial microparticles (EMPs) and soluble intercellular adhesion molecule-1 (sICAM-1) were measured by flow cytometry and Elisa. Results the levels of EMPs and sICAM-1 were significantly higher in the patient group than in the control group. The area under the curve of EMPs and sICAM-1 were 0.755 and 0.701, respectively, which indicated that there was a good correlation between EMPs and sICAM-1 levels and no reflow after PCI in AMI patients. Gensini scores and EMPs in coronary artery lesions increased with the increase of lesion branches, and the levels of EMPs were positively correlated with Gensini scores. Conclusion the levels of EMPs and sICAM-1 in circulating blood of patients with AMI can predict the occurrence of no reflow and the severity of coronary artery disease.
【作者單位】： 延安大學(xué)附屬醫(yī)院心腦血管病醫(yī)院心內(nèi)科三病區(qū);西安交通大學(xué)第二附屬醫(yī)院心血管內(nèi)科;
【基金】：延安市市級科技計劃項目(No.2013-kw02)~~
【分類號】：R542.22

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