本文選題：高血壓腦出血 + 炎癥因子�。� 參考：《中國老年學(xué)雜志》2017年12期

【摘要】：目的探討老年高血壓急性腦出血患者不同時間點(diǎn)炎癥因子水平變化及其與周圍腦組織水腫的關(guān)系。方法選擇83例老年高血壓急性腦出血患者,分別在急性腦出血6 h、12 h、24 h、3 d、7 d內(nèi)用酶聯(lián)免疫法測定患者血清及血腫液中炎癥因子的濃度并CT檢查動態(tài)觀察血腫及其周圍低密度,分析炎癥因子與周圍腦組織水腫的關(guān)系。同時選取45例健康成年體檢者作為正常對照組。結(jié)果白細(xì)胞介素(IL)-4、IL-6、IL-8濃度均在≥24且72 h達(dá)到峰值,第3~7天開始下降,但其水平均高于正常對照組(P0.05);而IL-10水平呈持續(xù)增高狀態(tài),7 d內(nèi)未觀察到峰值,除6 h內(nèi)差異無統(tǒng)計學(xué)意義外,其余時間患者水平均高于正常對照組(P0.05)。腦出血量與腦水腫量呈正相關(guān),均在≥12且24 h達(dá)峰值,且此時相關(guān)系數(shù)最高(r=0.698)。與正常對照組比較,高血壓腦出血患者血清和血腫液中4種炎癥因子水平均較高(P0.05);而患者血清和血腫液中4種炎癥因子水平比較差異無統(tǒng)計學(xué)意義(P0.05)。IL-4、IL-6、IL-8與水腫量均呈正相關(guān),而IL-10與水腫量呈負(fù)相關(guān);四種炎癥因子與出血量均無線性相關(guān)性(P0.05)。結(jié)論老年高血壓腦出血患者血清IL-4、IL-6、IL-8、IL-10水平均增高,并隨時間動態(tài)變化;四種炎癥因子均相互影響,與周圍腦組織水腫相關(guān)性由強(qiáng)到弱依次為IL-4、IL-10、IL-6、IL-8。
[Abstract]:Objective to investigate the changes of inflammatory factors at different time points in elderly patients with hypertensive acute intracerebral hemorrhage (AICH) and their relationship with edema of peripheral brain tissue. Methods Eighty-three elderly patients with hypertensive acute intracerebral hemorrhage were selected. The concentrations of inflammatory factors in serum and hematoma fluid were determined by enzyme-linked immunosorbent assay (Elisa) within 6 h, 12 h, 24 h and 3 d after acute intracerebral hemorrhage, and the dynamic observation of hematoma and its surrounding low density was performed by CT examination. To analyze the relationship between inflammatory factors and edema of peripheral brain tissue. At the same time, 45 healthy adults were selected as the normal control group. Results the concentration of IL-8 was more than 24 and reached the peak value at 72 h. It began to decrease on the 7th day, but the level was higher than that of the normal control group (P0.05), but the level of IL-10 was not observed within 7 days after the increase of IL-10. Except in 6 hours, the level of patients was higher than that of normal control group (P0.05). There was a positive correlation between the amount of cerebral hemorrhage and the amount of brain edema, all of them reached the peak value at 24 h and 鈮，

本文編號：2061530