發(fā)布時(shí)間：2018-06-21 19:59

  本文選題：益生菌 + 輕微肝性腦病��； 參考：《新疆醫(yī)科大學(xué)》2014年碩士論文

【摘要】：目的：本研究的目的是對(duì)已發(fā)表的有關(guān)于益生菌與常規(guī)保肝治療或安慰劑治療進(jìn)行對(duì)照研究的隨機(jī)對(duì)照試驗(yàn)進(jìn)行系統(tǒng)評(píng)價(jià),以明確現(xiàn)在是否有充分的證據(jù)可以證明益生菌對(duì)輕微肝性腦病治療的效果。方法：首先,制定明確的納入標(biāo)準(zhǔn)和排除標(biāo)準(zhǔn),應(yīng)用計(jì)算機(jī)檢索技術(shù)全面檢索Cochrane臨床對(duì)照試驗(yàn)數(shù)據(jù)庫、Medline、Embase、萬方醫(yī)學(xué)網(wǎng)、同方醫(yī)學(xué)網(wǎng)等相關(guān)數(shù)據(jù)庫,并手工檢索相關(guān)的會(huì)議論文以及所有檢索到的試驗(yàn)的參考文獻(xiàn),由兩位研究評(píng)價(jià)員分別對(duì)篩選出的文獻(xiàn)進(jìn)行相關(guān)資料的提取以及對(duì)文獻(xiàn)質(zhì)量和內(nèi)容進(jìn)行評(píng)價(jià),并且由兩位評(píng)價(jià)員相互核對(duì)。然后對(duì)符合納入條件的文獻(xiàn)進(jìn)行整理以及資料整合。采用血氨監(jiān)測(cè)、心理系統(tǒng)檢測(cè)、臨床型肝性腦病發(fā)病率等標(biāo)準(zhǔn)評(píng)價(jià)益生菌對(duì)輕微肝性腦病患者的療效。結(jié)果：總共檢索到的可能符合納入標(biāo)準(zhǔn)的文獻(xiàn)有12篇,其中6個(gè)試驗(yàn)共包括340例患者符合納入標(biāo)準(zhǔn)。但是,經(jīng)Jadad評(píng)分后,各試驗(yàn)質(zhì)量相差很大。所有納入試驗(yàn)的患者均為肝硬化以及門脈高壓且排除臨床型肝性腦病患者。益生菌治療后相關(guān)檢測(cè)指標(biāo)均提示益生菌對(duì)輕微肝性腦病有良好療效,且和對(duì)照組相比較有明顯差異(P0.05)。輕微肝性腦病逆轉(zhuǎn)率明顯較對(duì)照組高,差別有顯著差異(P0.05)。結(jié)論：本系統(tǒng)評(píng)價(jià)顯示益生菌對(duì)輕微肝性腦病的治療、逆轉(zhuǎn)、相關(guān)檢測(cè)指標(biāo)的改善明顯優(yōu)于常規(guī)治療以及安慰劑。但是,因?yàn)楝F(xiàn)在輕微肝性腦病治療的研究較少,高質(zhì)量以及大樣本的研究更加缺乏,所得結(jié)論有一定局限性。因此,需進(jìn)行更加嚴(yán)謹(jǐn)以及大樣本、多中心的相關(guān)試驗(yàn)以進(jìn)一步提高試驗(yàn)結(jié)論的可靠性。同時(shí),相關(guān)研究應(yīng)盡可能長時(shí)間隨訪,并嚴(yán)格遵守隨機(jī)、雙盲以及對(duì)失訪患者進(jìn)行原因探查。
[Abstract]:Objective: the purpose of this study was to systematically evaluate the published randomized controlled trials of probiotics and conventional liver preservation or placebo treatment to determine whether there is sufficient evidence to prove the effect of probiotics on treatment of mild hepatic encephalopathy. The standard and exclusion criteria are used to retrieve Cochrane clinical trial database, Medline, Embase, Wanfang medical network, Tongfang medical network and other related databases, and manual retrieval of related conference papers and all the referenced references of the retrieved tests by two research evaluators. The related data were extracted and the quality and content of the literature were evaluated, and the two evaluators checked each other. Then the documents were collated and the data were integrated. The therapeutic effect of probiotics on mild hepatic encephalopathy was evaluated by blood ammonia monitoring, psychological system detection, and the incidence of clinical hepatic encephalopathy. Results: a total of 12 articles were found to be eligible for inclusion criteria. 6 of them included 340 patients who met the inclusion criteria. However, after Jadad scores, the quality of each test was very different. All the patients included were cirrhosis and portal hypertension and patients with clinical hepatic encephalopathy were excluded. Probiotics were associated with the treatment. The results showed that probiotics had a good effect on mild hepatic encephalopathy and compared with the control group (P0.05). The reversal rate of mild hepatic encephalopathy was significantly higher than that of the control group (P0.05). Conclusion: the system evaluation showed that the treatment of probiotics to mild hepatic encephalopathy was reversed and the related indexes were improved. It is better than conventional therapy and placebo. However, because of the few studies on the treatment of mild hepatic encephalopathy and the lack of high quality and large sample studies, the conclusions are limited. Therefore, more rigorous and large sample, multi center related experiments are needed to further improve the reliability of the test conclusions. The study should be followed up for as long as possible and strictly observe the causes of blindness, double blindness and missed visit.
【學(xué)位授予單位】：新疆醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類號(hào)】：R575.3

【參考文獻(xiàn)】

相關(guān)期刊論文 前5條

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本文編號(hào)：2049837