本文選題：腦卒中后抑郁 + 發(fā)生率��； 參考：《皖南醫(yī)學(xué)院》2013年碩士論文

【摘要】：目的：本文為揭示急性期PSD的高患病率并探討其相關(guān)危險因素，以提高臨床醫(yī)生對PSD的重視，為早期診斷、早期治療提供臨床依據(jù)。方法：研究方案：采用病例－對照研究方案。病例資料采集方法：選擇馬鞍山十七冶醫(yī)院神經(jīng)內(nèi)科和皖南醫(yī)學(xué)院附屬醫(yī)院神經(jīng)內(nèi)、外科2011年1月至2011年12月住院的符合標(biāo)準(zhǔn)的急性期腦卒中患者120例。收集患者常規(guī)資料包括一般情況調(diào)查、既往病史、頭顱CT或MRI檢查。在患者發(fā)病第14天后，給予相關(guān)量表的評估。按照中國精神障礙類與診斷標(biāo)準(zhǔn)第3版（CCMD-3）抑郁癥診斷標(biāo)準(zhǔn)及Hamilton抑郁量表評分，將患者分為抑郁組和對照組。神經(jīng)功能缺損程度評分以采用美國國立衛(wèi)生院卒中量表(NIHSS)，采用日常生活活動量表（ADL）評估生活能力,統(tǒng)計學(xué)處理：應(yīng)用SPSS17.0統(tǒng)計軟件，對單因素計量資料行t檢驗，Mann-Whitney U秩和檢驗，單因素計數(shù)資料采用χ2檢驗，，符合P0.05的因素采用二分類Logistic回歸分析。結(jié)果：1共調(diào)查了120例患者，最后能夠配合完成所有調(diào)查任務(wù)的有102例,PSD的發(fā)生率102例患者合并PSD46例，發(fā)生率45.1%；2.從腦卒中的特點來看，PSD的發(fā)生與卒中的性質(zhì)，部位在統(tǒng)計學(xué)上無明顯差異（P0.05），左半球、雙側(cè)半球、腦干部位可能是更易發(fā)生PSD；3PSD的發(fā)生率與性別、年齡、經(jīng)濟(jì)、職業(yè)、文化水平、糖尿病、高血壓無顯著相關(guān)性，但與配偶情況、合并癥多有關(guān)；4研究發(fā)現(xiàn)NIHSS評分，ADL評分與PSD相關(guān)性明顯，ADL評分高是PSD的保護(hù)因素。結(jié)論： PSD在腦卒中患者中發(fā)病率高，是腦卒中患者常見且嚴(yán)重的并發(fā)癥。PSD的發(fā)生率與性別、年齡、經(jīng)濟(jì)、職業(yè)、文化水平、無顯著相關(guān)性；但與神經(jīng)功能缺損（NIHSS）和日�；顒幽芰ΓˋDL）相關(guān)性明顯。PSD發(fā)生率可能與婚姻和腦血管危險因素有關(guān)，但還需要大樣本研究。
[Abstract]:Objective: to reveal the high prevalence rate of PSD in acute stage and to explore its related risk factors in order to increase the attention of clinicians to PSD and to provide clinical basis for early diagnosis and early treatment. Methods: a case-control study was used. Methods: 120 patients with acute stroke who were hospitalized in Department of Neurology and affiliated Hospital of Southern Anhui Medical College from January 2011 to December 2011 in Maanshan Seventeenth Metallurgical Hospital were selected. Routine data were collected, including general investigation, past medical history, head CT or MRI examination. The patients were evaluated with the relevant scales 14 days after onset. Patients were divided into depression group and control group according to CCMD-3) and Hamilton Depression scale. The degree of neurological impairment was evaluated by the National Institutes of Health Stroke scale (NIHSSSS) and ADL (Daily living activity scale). Statistical analysis was performed with SPSS 17.0 statistical software, and Mann-Whitney U rank sum test was performed on the single factor measurement data. The data of single factor count were analyzed by 蠂 2 test, and the factors in accordance with P 0.05 were analyzed by logistic regression analysis. Results one hundred and twenty patients were investigated by 1: 1 and 102 cases of PSD were found to be able to cooperate with all the investigation tasks. The incidence of PSD was 46 cases in 102 cases (45.1%). According to the characteristics of stroke, there was no statistical difference in the occurrence and nature of PSD. The left hemisphere, bilateral hemispheres and brainstem may be more likely to occur PSD3PSD with sex, age, economy, occupation and education level. There was no significant correlation between diabetes mellitus and hypertension, but there was a significant correlation between NIHSS score and PSD, but there was a significant correlation between NIHSS score and ADL score. The higher ADL score was the protective factor of PSD. Conclusion: the incidence of PSD in stroke patients is high. The incidence of PSD is a common and serious complication in stroke patients. There is no significant correlation between PSD incidence and sex, age, economy, occupation, education level. The incidence of PSD may be related to marriage and cerebrovascular risk factors, but large sample study is needed.
【學(xué)位授予單位】：皖南醫(yī)學(xué)院
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2013
【分類號】：R743.3

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