本文選題：顱腦損傷 + 亞低溫��； 參考：《山東醫(yī)藥》2017年18期

【摘要】：目的觀察亞低溫治療對急性重型顱腦損傷患者血清泛素羧基端水解酶-1(UCH-L1)、神經(jīng)膠質(zhì)纖維酸性蛋白(GFAP)及其預后的影響。方法將110例急性重型顱腦損傷患者隨機分為觀察組和對照組各55例,兩組均積極行手術(shù)治療,并加強吸氧、抗感染及脫水等治療,及時糾正患者水電解質(zhì)紊亂及酸堿失衡,后期可采用高壓氧等治療。觀察組術(shù)后進行亞低溫治療,亞低溫維持時間3~7 d。分別于入院時和入院后24、48、72 h及第5天取空腹靜脈血,采用酶聯(lián)免疫吸附法檢測血清UCH-L1、GFAP;隨訪6個月,采用格拉斯哥預后評分(GOS)評價其預后。結(jié)果治療前兩組血清UCH-L1、GFAP水平比較,P均0.05;兩組治療后24、48、72 h及第5天血清UCHL1、GFAP水平均下降(P均0.05),且觀察組治療后各時間點血清UCH-L1、GFAP水平明顯低于對照組(P均0.05)。隨訪6個月,觀察組預后良好率56.36%、病死率9.09%,對照組分別為29.09%、25.45%,兩組比較P均0.05。結(jié)論亞低溫治療急性重型顱腦損傷可降低血清UCH-L1、GFAP水平,從而更好地改善患者預后。
[Abstract]:Objective To observe the effect of mild hypothermia on serum carboxyl terminal hydrolase -1 (UCH-L1), glial fibrillary acidic protein (GFAP) and its prognosis in patients with acute severe craniocerebral injury. Methods 110 patients with acute severe craniocerebral injury were randomly divided into the observation group and the control group (55 cases each). The two groups were actively operated on, and the oxygen inhalation and anti sensation were strengthened. Dyed and dehydration treatment, timely correction of water electrolyte disturbance and acid-base imbalance, and later treatment with hyperbaric oxygen. The observation group was treated with hypothermia after operation, the subhypothermia maintenance time 3~7 D. was taken at the time of admission and 24,48,72 h and 5 days after admission, and serum UCH-L1, GFAP were detected by enzyme linked immunosorbent assay, followed up for 6. The prognosis was evaluated by the Glasgow prognostic score (GOS). The results of serum UCH-L1, GFAP and P were 0.05 in the two groups before treatment, and in the two groups after 24,48,72 h and 5 days, the level of UCHL1 and GFAP decreased (P 0.05), and the serum UCH-L1 in the observation group was significantly lower than that of the control group (P are 0.05) at all time points after treatment. The follow-up period was 6 months, The good prognosis rate of the observation group was 56.36%, the mortality rate was 9.09%, the control group was 29.09%, 25.45%, and the two groups compared P 0.05. conclusion that the mild hypothermia treatment of acute severe craniocerebral injury could reduce the level of serum UCH-L1 and GFAP, thus better improve the prognosis of the patients.
【作者單位】： 重慶市涪陵中心醫(yī)院;
【分類號】：R651.15
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本文編號：1958883