本文選題：降鈣素原 + 多器官功能障礙綜合征　； 參考：《重慶醫(yī)科大學(xué)》2013年碩士論文

【摘要】：背景：多器官功能障礙綜合征(multiple organ dysfunctionsyndrome，MODS)是嚴(yán)重創(chuàng)傷、嚴(yán)重感染患者的常見并發(fā)癥，病死率較高。MODS患者的早期診斷對(duì)患者的預(yù)后至關(guān)重要。國內(nèi)外學(xué)者研究了血清清降鈣素原（Procalcitonin, PCT）在嚴(yán)重創(chuàng)傷致MODS患者中的變化，，并對(duì)其早期診斷的臨床應(yīng)用價(jià)值進(jìn)行了探討。 目的：對(duì)血清PCT用于早期診斷MODS的價(jià)值進(jìn)行系統(tǒng)性評(píng)價(jià)。 方法：計(jì)算機(jī)檢索PubMed、ISLBPMEDLINE數(shù)據(jù)庫、Springlink數(shù)據(jù)庫、萬方數(shù)據(jù)知識(shí)服務(wù)平臺(tái)、中國知網(wǎng)、中國生物醫(yī)學(xué)文獻(xiàn)數(shù)據(jù)庫和維普中文科技期刊數(shù)據(jù)庫。檢索年限為1990年1月至2012年3月。收集相關(guān)的原始研究文獻(xiàn)，并通過閱讀摘要及全文分析，根據(jù)納入條件進(jìn)行篩選。通過QUADAS質(zhì)量評(píng)價(jià)標(biāo)準(zhǔn)評(píng)估納入文獻(xiàn)質(zhì)量。使用Review Manger5.14軟件對(duì)納入文獻(xiàn)的數(shù)據(jù)做連續(xù)性變量的加權(quán)平均數(shù)差（WMD）、標(biāo)準(zhǔn)化平均數(shù)差（SMD）以及95%置信區(qū)間（CI）分析，并繪制漏斗圖以判斷偏倚。 結(jié)果： （1）共檢索出相關(guān)英文文獻(xiàn)27篇，中文文獻(xiàn)26篇。 （2）通過閱讀標(biāo)題、摘要和全文，嚴(yán)格按照納入標(biāo)準(zhǔn)，最終獲取文獻(xiàn)9篇，其中英文文獻(xiàn)3篇，中文文獻(xiàn)6篇。 （3）對(duì)納入文獻(xiàn)使用Review Manger5.14軟件進(jìn)行分析，其WMD分析結(jié)果以及95%CI(置信區(qū)間)分別為為4.22（2.845.61）。 （4）對(duì)納入文獻(xiàn)使用Review Manger5.14軟件進(jìn)行分析，其SMD分析結(jié)果以及95%CI分別為1.79（0.902.68）。 結(jié)論：PCT對(duì)MODS的早期診斷有應(yīng)用價(jià)值，且在并發(fā)多MODS患者入院后24小時(shí)即可檢測(cè)，可作為早期預(yù)測(cè)MODS的獨(dú)立指標(biāo)。
[Abstract]:Background: multiple organ dysfunctional syndrome (mods) is a common complication in patients with severe trauma and severe infection. The early diagnosis of multiple organ dysfunction syndrome (mods) is very important to the prognosis of patients with mods. The changes of Procalcitonin (PCT) in patients with MODS caused by severe trauma were studied, and the clinical value of its early diagnosis was discussed. Objective: to evaluate the value of serum PCT in early diagnosis of MODS. Methods: a computer-based search was conducted on the PubMedine ISLBPMEDLINE database, the Springlink database, the Wanfang data knowledge Service platform, the China knowledge Network, the Chinese Biomedical Literature Database and the Weipu Chinese Science and Technology Journal Database. The retrieval period is from January 1990 to March 2012. Collect relevant original research documents and select according to inclusion condition by reading abstract and full text analysis. Literature quality is included through QUADAS quality evaluation criteria. The Review Manger5.14 software is used to analyze the weighted mean difference of the continuity variable, the standardized average difference and the 95% confidence interval (CI), and to draw the funnel diagram to judge the bias. Results: A total of 27 English and 26 Chinese literatures were found. (2) by reading the title, abstract and full text, according to the inclusion criteria, 9 papers were obtained, of which 3 were in Chinese and English, and 6 in Chinese. The results of WMD analysis and 95 CI (confidence interval) are 4.22 / 2.845.61 respectively. The results of SMD analysis and 95%CI were 1.790.902.68 and 1.790.902.68 respectively. Conclusion it is valuable for early diagnosis of MODS and can be detected 24 hours after admission in patients with multiple MODS. It can be used as an independent index for early prediction of MODS.
【學(xué)位授予單位】：重慶醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2013
【分類號(hào)】：R459.7

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